Increased T lymphocytes bearing the gamma-delta T cell receptor in subjects at high risk for insulin dependent diabetes

Francois P. Lang, Desmond A. Schatz, Bradley H Pollock, William J. Riley, Noel K. Maclaren, Marilyn Dumont-Driscoll, Douglas J. Barrett

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The effector mechanisms responsible for autoimmune β cell destruction in insulin dependent (type 1) diabetes (IDD) remain elusive. In order to investigate whether T lymphocytes bearing the gamma-delta T cell receptor (γδ+ T cells) could be involved in this process, we measured percentages of peripheral blood γδ+ T cells in IDD patients, relatives of IDD probands and controls. High levels of γδ+ T cells strongly differentiated 23 relatives at high risk for IDD on the basis of positive islet cell autoantibodies (ICA positive relatives) from 59 controls (P = 0.0013), whereas 26 ICA negative relatives, 14 recent-onset and nine long term IDD patients could not be distinguished from controls on the basis of percentages of γδ+ T cells. These data suggest that increased levels of circulating γδ+ T cells correlate with the ongoing autoimmune process in pancreatic islets of subjects at high risk for IDD and may thus represent an additional marker for the development of the disease.

Original languageEnglish (US)
Pages (from-to)925-933
Number of pages9
JournalJournal of Autoimmunity
Volume4
Issue number6
DOIs
StatePublished - 1991
Externally publishedYes

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Antigen Receptors, T-Cell, gamma-delta
Insulin
T-Lymphocytes
Islets of Langerhans
Type 1 Diabetes Mellitus
Autoantibodies
Blood Cells

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Increased T lymphocytes bearing the gamma-delta T cell receptor in subjects at high risk for insulin dependent diabetes. / Lang, Francois P.; Schatz, Desmond A.; Pollock, Bradley H; Riley, William J.; Maclaren, Noel K.; Dumont-Driscoll, Marilyn; Barrett, Douglas J.

In: Journal of Autoimmunity, Vol. 4, No. 6, 1991, p. 925-933.

Research output: Contribution to journalArticle

Lang, Francois P. ; Schatz, Desmond A. ; Pollock, Bradley H ; Riley, William J. ; Maclaren, Noel K. ; Dumont-Driscoll, Marilyn ; Barrett, Douglas J. / Increased T lymphocytes bearing the gamma-delta T cell receptor in subjects at high risk for insulin dependent diabetes. In: Journal of Autoimmunity. 1991 ; Vol. 4, No. 6. pp. 925-933.
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abstract = "The effector mechanisms responsible for autoimmune β cell destruction in insulin dependent (type 1) diabetes (IDD) remain elusive. In order to investigate whether T lymphocytes bearing the gamma-delta T cell receptor (γδ+ T cells) could be involved in this process, we measured percentages of peripheral blood γδ+ T cells in IDD patients, relatives of IDD probands and controls. High levels of γδ+ T cells strongly differentiated 23 relatives at high risk for IDD on the basis of positive islet cell autoantibodies (ICA positive relatives) from 59 controls (P = 0.0013), whereas 26 ICA negative relatives, 14 recent-onset and nine long term IDD patients could not be distinguished from controls on the basis of percentages of γδ+ T cells. These data suggest that increased levels of circulating γδ+ T cells correlate with the ongoing autoimmune process in pancreatic islets of subjects at high risk for IDD and may thus represent an additional marker for the development of the disease.",
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