Abstract
The time necessary for aortic diastolic pressure to decrease to 50 percent of an initially selected value after dissipation of the dicrotic notch (T 1 2) was determined in newborn infants with and without pulmonary hypertension. The mean T 1 2 was 671 ± 167 msec in seven infants with clinical evidence of pulmonary hypertension and documented right to left ductus arteriosus shunting; 849 ± 243 msec in nine infants with clinical evidence of pulmonary hypertension but no documented right to left ductus arteriosus shunting; and 457 ± 66 msec in eight infants with hyaline membrane disease and no clinical evidence of pulmonary hypertension or a patent ductus arteriosus. The mean T 1 2 values in the former two groups were significantly different from that in the group with no pulmonary hypertension (P < 0.01). An evaluation of factors affecting T 1 2 leads to the conclusion that the patients with pulmonary hypertension had increased systemic vascular resistance as well. This finding has important diagnostic, etiologic and therapeutic implications.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1159-1162 |
| Number of pages | 4 |
| Journal | The American journal of cardiology |
| Volume | 44 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1979 |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Increased systemic vascular resistance in neonates with pulmonary hypertension. / Milstein, Jay M; Goetzman, Boyd W.; Riemenschneider, Thomas A.; Wennberg, Richard P.
In: The American journal of cardiology, Vol. 44, No. 6, 1979, p. 1159-1162.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Increased systemic vascular resistance in neonates with pulmonary hypertension
AU - Milstein, Jay M
AU - Goetzman, Boyd W.
AU - Riemenschneider, Thomas A.
AU - Wennberg, Richard P.
PY - 1979
Y1 - 1979
N2 - The time necessary for aortic diastolic pressure to decrease to 50 percent of an initially selected value after dissipation of the dicrotic notch (T 1 2) was determined in newborn infants with and without pulmonary hypertension. The mean T 1 2 was 671 ± 167 msec in seven infants with clinical evidence of pulmonary hypertension and documented right to left ductus arteriosus shunting; 849 ± 243 msec in nine infants with clinical evidence of pulmonary hypertension but no documented right to left ductus arteriosus shunting; and 457 ± 66 msec in eight infants with hyaline membrane disease and no clinical evidence of pulmonary hypertension or a patent ductus arteriosus. The mean T 1 2 values in the former two groups were significantly different from that in the group with no pulmonary hypertension (P < 0.01). An evaluation of factors affecting T 1 2 leads to the conclusion that the patients with pulmonary hypertension had increased systemic vascular resistance as well. This finding has important diagnostic, etiologic and therapeutic implications.
AB - The time necessary for aortic diastolic pressure to decrease to 50 percent of an initially selected value after dissipation of the dicrotic notch (T 1 2) was determined in newborn infants with and without pulmonary hypertension. The mean T 1 2 was 671 ± 167 msec in seven infants with clinical evidence of pulmonary hypertension and documented right to left ductus arteriosus shunting; 849 ± 243 msec in nine infants with clinical evidence of pulmonary hypertension but no documented right to left ductus arteriosus shunting; and 457 ± 66 msec in eight infants with hyaline membrane disease and no clinical evidence of pulmonary hypertension or a patent ductus arteriosus. The mean T 1 2 values in the former two groups were significantly different from that in the group with no pulmonary hypertension (P < 0.01). An evaluation of factors affecting T 1 2 leads to the conclusion that the patients with pulmonary hypertension had increased systemic vascular resistance as well. This finding has important diagnostic, etiologic and therapeutic implications.
UR - http://www.scopus.com/inward/record.url?scp=0018577955&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018577955&partnerID=8YFLogxK
U2 - 10.1016/0002-9149(79)90182-6
DO - 10.1016/0002-9149(79)90182-6
M3 - Article
VL - 44
SP - 1159
EP - 1162
JO - American Journal of Cardiology
JF - American Journal of Cardiology
SN - 0002-9149
IS - 6
ER -