TY - JOUR
T1 - Increased systemic vascular resistance in neonates with pulmonary hypertension
AU - Milstein, Jay M
AU - Goetzman, Boyd W.
AU - Riemenschneider, Thomas A.
AU - Wennberg, Richard P.
PY - 1979
Y1 - 1979
N2 - The time necessary for aortic diastolic pressure to decrease to 50 percent of an initially selected value after dissipation of the dicrotic notch (T 1 2) was determined in newborn infants with and without pulmonary hypertension. The mean T 1 2 was 671 ± 167 msec in seven infants with clinical evidence of pulmonary hypertension and documented right to left ductus arteriosus shunting; 849 ± 243 msec in nine infants with clinical evidence of pulmonary hypertension but no documented right to left ductus arteriosus shunting; and 457 ± 66 msec in eight infants with hyaline membrane disease and no clinical evidence of pulmonary hypertension or a patent ductus arteriosus. The mean T 1 2 values in the former two groups were significantly different from that in the group with no pulmonary hypertension (P < 0.01). An evaluation of factors affecting T 1 2 leads to the conclusion that the patients with pulmonary hypertension had increased systemic vascular resistance as well. This finding has important diagnostic, etiologic and therapeutic implications.
AB - The time necessary for aortic diastolic pressure to decrease to 50 percent of an initially selected value after dissipation of the dicrotic notch (T 1 2) was determined in newborn infants with and without pulmonary hypertension. The mean T 1 2 was 671 ± 167 msec in seven infants with clinical evidence of pulmonary hypertension and documented right to left ductus arteriosus shunting; 849 ± 243 msec in nine infants with clinical evidence of pulmonary hypertension but no documented right to left ductus arteriosus shunting; and 457 ± 66 msec in eight infants with hyaline membrane disease and no clinical evidence of pulmonary hypertension or a patent ductus arteriosus. The mean T 1 2 values in the former two groups were significantly different from that in the group with no pulmonary hypertension (P < 0.01). An evaluation of factors affecting T 1 2 leads to the conclusion that the patients with pulmonary hypertension had increased systemic vascular resistance as well. This finding has important diagnostic, etiologic and therapeutic implications.
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U2 - 10.1016/0002-9149(79)90182-6
DO - 10.1016/0002-9149(79)90182-6
M3 - Article
C2 - 495510
AN - SCOPUS:0018577955
VL - 44
SP - 1159
EP - 1162
JO - American Journal of Cardiology
JF - American Journal of Cardiology
SN - 0002-9149
IS - 6
ER -