Increased susceptibility to Salmonella infection in signal regulatory protein α-deficient mice

Lin Xi Li, Shaikh M. Atif, Shirdi E. Schmiel, Seung Joo Lee, Stephen J Mcsorley

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Recent studies have shed light on the connection between elevated erythropoetin production/spleen erythropoiesis and increased susceptibility to Salmonella infection. In this article, we provide another mouse model, the SIRPa-deficient (Sirpα-/-) mouse, that manifests increased erythropoiesis as well as heightened susceptibility to Salmonella infection. Sirpα-/- mice succumbed to systemic infection with attenuated Salmonella, possessing significantly higher bacterial loads in both the spleen and the liver. Moreover, Salmonella-specific Ab production and Ag-specific CD4 T cells were reduced in Sirpα-/- mice compared with wild-type controls. To further characterize the potential mechanism underlying SIRPα-dependent Ag-specific CD4 T cell priming, we demonstrate that lack of SIRPα expression on dendritic cells results in less efficient Ag processing and presentation in vitro. Collectively, these findings demonstrate an indispensable role of SIRPα for protective immunity to Salmonella infection.

Original languageEnglish (US)
Pages (from-to)2537-2544
Number of pages8
JournalJournal of Immunology
Volume189
Issue number5
DOIs
StatePublished - Sep 1 2012

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Salmonella Infections
Erythropoiesis
Salmonella
Proteins
Spleen
T-Lymphocytes
Bacterial Load
Dendritic Cells
Immunity
Liver
Infection

ASJC Scopus subject areas

  • Immunology

Cite this

Increased susceptibility to Salmonella infection in signal regulatory protein α-deficient mice. / Li, Lin Xi; Atif, Shaikh M.; Schmiel, Shirdi E.; Lee, Seung Joo; Mcsorley, Stephen J.

In: Journal of Immunology, Vol. 189, No. 5, 01.09.2012, p. 2537-2544.

Research output: Contribution to journalArticle

Li, Lin Xi ; Atif, Shaikh M. ; Schmiel, Shirdi E. ; Lee, Seung Joo ; Mcsorley, Stephen J. / Increased susceptibility to Salmonella infection in signal regulatory protein α-deficient mice. In: Journal of Immunology. 2012 ; Vol. 189, No. 5. pp. 2537-2544.
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