Increased spontaneous activity of antibody-forming cells in the peripheral blood of patients with active SLE.

D. R. Budman, E. B. Merchant, A. D. Steinberg, B. Doft, M. Eric Gershwin, E. Lizzio, J. P. Reeves

Research output: Contribution to journalArticle

128 Scopus citations

Abstract

Thirty-seven patients with criteria for systemic lupus erythematosus (SLE) and 18 normal controls were studied for their spontaneous background IgM antibody plaque-forming clell number to specific chemical haptens. Active SLE patients had significantly more plaque-forming cells in their peripheral blood to a total of five chemical determinants than did patients with inactive disease or controls. This increased number of plaque forming-cells correlated with depressed serum C3 levels by Spearman rank-order analysis. The finding of elevated numberof spontaneous IgM plaque-forming cells to defined chemical haptens supports the concept that active SLE demonstrates a generalized increase in B-cell activity toward a variety of antigens.

Original languageEnglish (US)
Pages (from-to)829-833
Number of pages5
JournalArthritis and Rheumatism
Volume20
Issue number3
StatePublished - Apr 1977
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

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    Budman, D. R., Merchant, E. B., Steinberg, A. D., Doft, B., Gershwin, M. E., Lizzio, E., & Reeves, J. P. (1977). Increased spontaneous activity of antibody-forming cells in the peripheral blood of patients with active SLE. Arthritis and Rheumatism, 20(3), 829-833.