Abstract
Thirty-seven patients with criteria for systemic lupus erythematosus (SLE) and 18 normal controls were studied for their spontaneous background IgM antibody plaque-forming clell number to specific chemical haptens. Active SLE patients had significantly more plaque-forming cells in their peripheral blood to a total of five chemical determinants than did patients with inactive disease or controls. This increased number of plaque forming-cells correlated with depressed serum C3 levels by Spearman rank-order analysis. The finding of elevated numberof spontaneous IgM plaque-forming cells to defined chemical haptens supports the concept that active SLE demonstrates a generalized increase in B-cell activity toward a variety of antigens.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 829-833 |
| Number of pages | 5 |
| Journal | Arthritis and Rheumatism |
| Volume | 20 |
| Issue number | 3 |
| State | Published - Apr 1977 |
| Externally published | Yes |
ASJC Scopus subject areas
- Immunology
- Rheumatology
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Cite this
Budman, D. R., Merchant, E. B., Steinberg, A. D., Doft, B., Gershwin, M. E., Lizzio, E., & Reeves, J. P. (1977). Increased spontaneous activity of antibody-forming cells in the peripheral blood of patients with active SLE. Arthritis and Rheumatism, 20(3), 829-833.