Increased social fear and decreased fear of objects in monkeys with neonatal amygdala lesions

M. D. Prather, P. Lavenex, M. L. Mauldin-Jourdain, W. A. Mason, J. P. Capitanio, S. P. Mendoza, David G Amaral

Research output: Contribution to journalArticle

199 Citations (Scopus)

Abstract

The amygdala has been implicated in the mediation of emotional and species-specific social behavior (Kling et al., 1970; Kling and Brothers, 1992; Kluver and Bucy, 1939; Rosvold et al., 1954). Humans with bilateral amygdala damage are impaired in judging negative emotion in facial expressions and making accurate judgements of trustworthiness (Adolphs et al., 1998, 1994). Amygdala dysfunction has also been implicated in human disorders ranging from social anxiety (Birbaumer et al., 1998) to depression (Drevets, 2000) to autism (Bachevalier, 1994; Baron-Cohen et al., 2000; Bauman and Kemper, 1993). We produced selective amygdala lesions in 2-week-old macaque monkeys who were returned to their mothers for rearing. At 6-8 months of age, the lesioned animals demonstrated less fear of novel objects such as rubber snakes than age-matched controls. However, they displayed substantially more fear behavior than controls during dyadic social interactions. These results suggest that neonatal amygdala lesions dissociate a system that mediates social fear from one that mediates fear of inanimate objects. Furthermore, much of the age-appropriate repertoire of social behavior was present in amygdala-lesioned infants indicating that these lesions do not produce autistic-like behavior in monkeys. Finally, amygdala lesions early in development have different effects on social behavior than lesions produced in adulthood.

Original languageEnglish (US)
Pages (from-to)653-658
Number of pages6
JournalNeuroscience
Volume106
Issue number4
DOIs
StatePublished - Oct 31 2001

Fingerprint

Amygdala
Fear
Haplorhini
Social Behavior
Facial Expression
Behavior Control
Snakes
Rubber
Macaca
Interpersonal Relations
Autistic Disorder
Siblings
Emotions
Mothers
Depression

Keywords

  • Amygdaloid complex
  • Autism
  • Social anxiety
  • Social behavior

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Prather, M. D., Lavenex, P., Mauldin-Jourdain, M. L., Mason, W. A., Capitanio, J. P., Mendoza, S. P., & Amaral, D. G. (2001). Increased social fear and decreased fear of objects in monkeys with neonatal amygdala lesions. Neuroscience, 106(4), 653-658. https://doi.org/10.1016/S0306-4522(01)00445-6

Increased social fear and decreased fear of objects in monkeys with neonatal amygdala lesions. / Prather, M. D.; Lavenex, P.; Mauldin-Jourdain, M. L.; Mason, W. A.; Capitanio, J. P.; Mendoza, S. P.; Amaral, David G.

In: Neuroscience, Vol. 106, No. 4, 31.10.2001, p. 653-658.

Research output: Contribution to journalArticle

Prather, MD, Lavenex, P, Mauldin-Jourdain, ML, Mason, WA, Capitanio, JP, Mendoza, SP & Amaral, DG 2001, 'Increased social fear and decreased fear of objects in monkeys with neonatal amygdala lesions', Neuroscience, vol. 106, no. 4, pp. 653-658. https://doi.org/10.1016/S0306-4522(01)00445-6
Prather MD, Lavenex P, Mauldin-Jourdain ML, Mason WA, Capitanio JP, Mendoza SP et al. Increased social fear and decreased fear of objects in monkeys with neonatal amygdala lesions. Neuroscience. 2001 Oct 31;106(4):653-658. https://doi.org/10.1016/S0306-4522(01)00445-6
Prather, M. D. ; Lavenex, P. ; Mauldin-Jourdain, M. L. ; Mason, W. A. ; Capitanio, J. P. ; Mendoza, S. P. ; Amaral, David G. / Increased social fear and decreased fear of objects in monkeys with neonatal amygdala lesions. In: Neuroscience. 2001 ; Vol. 106, No. 4. pp. 653-658.
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