Increased severity of fragile X spectrum disorders in the agricultural community of Ricaurte, Colombia

Wilmar Saldarriaga; María J. Salcedo-Arellano; Tatiana Rodriguez-Guerrero; Marcela Ríos; Andrés Fandiño-Losada; Julian Ramirez-Cheyne; Pamela J Lein; Flora Tassone; Randi J Hagerman

doi:10.1016/j.ijdevneu.2018.10.002

Increased severity of fragile X spectrum disorders in the agricultural community of Ricaurte, Colombia

Wilmar Saldarriaga, María J. Salcedo-Arellano, Tatiana Rodriguez-Guerrero, Marcela Ríos, Andrés Fandiño-Losada, Julian Ramirez-Cheyne, Pamela J Lein, Flora Tassone, Randi J Hagerman

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Premutation carriers of the FMR1 gene (CGG repeats between 55 and 200) usually have normal intellectual abilities but approximately 20% are diagnosed with developmental problems or autism spectrum disorder. Additionally, close to 50% have psychiatric problems such as anxiety, ADHD and/or depression. The spectrum of fragile X disorders also includes Fragile-X-associated primary ovarian insufficiency (FXPOI) in female carriers and Fragile-X-associated tremor/ataxia syndrome (FXTAS) in older male and female carriers. We evaluated 25 premutation carriers in the rural community of Ricaurte Colombia and documented all behavioral problems, social deficits and clinical signs of FXPOI and FXTAS as well as reviewed the medical and obstetric history. We found an increased frequency and severity of symptoms of fragile X spectrum disorders, which might be related to the vulnerability of FMR1 premutation carriers to higher exposure to neurotoxic pesticides in this rural community.

Original language	English (US)
Pages (from-to)	1-5
Number of pages	5
Journal	International Journal of Developmental Neuroscience
Volume	72
DOIs	https://doi.org/10.1016/j.ijdevneu.2018.10.002
State	Published - Feb 1 2019

Keywords

Colombia
Fragile X spectrum disorders
Fragile X syndrome
FXPOI
FXTAS

ASJC Scopus subject areas

Developmental Neuroscience
Developmental Biology

Access to Document

10.1016/j.ijdevneu.2018.10.002

Fingerprint Dive into the research topics of 'Increased severity of fragile X spectrum disorders in the agricultural community of Ricaurte, Colombia'. Together they form a unique fingerprint.

Cite this

Saldarriaga, W., Salcedo-Arellano, M. J., Rodriguez-Guerrero, T., Ríos, M., Fandiño-Losada, A., Ramirez-Cheyne, J., Lein, P. J., Tassone, F., & Hagerman, R. J. (2019). Increased severity of fragile X spectrum disorders in the agricultural community of Ricaurte, Colombia. International Journal of Developmental Neuroscience, 72, 1-5. https://doi.org/10.1016/j.ijdevneu.2018.10.002

Increased severity of fragile X spectrum disorders in the agricultural community of Ricaurte, Colombia. / Saldarriaga, Wilmar; Salcedo-Arellano, María J.; Rodriguez-Guerrero, Tatiana; Ríos, Marcela; Fandiño-Losada, Andrés; Ramirez-Cheyne, Julian; Lein, Pamela J ; Tassone, Flora ; Hagerman, Randi J.

In: International Journal of Developmental Neuroscience, Vol. 72, 01.02.2019, p. 1-5.

Research output: Contribution to journal › Article › peer-review

Saldarriaga, W, Salcedo-Arellano, MJ, Rodriguez-Guerrero, T, Ríos, M, Fandiño-Losada, A, Ramirez-Cheyne, J, Lein, PJ , Tassone, F & Hagerman, RJ 2019, 'Increased severity of fragile X spectrum disorders in the agricultural community of Ricaurte, Colombia', International Journal of Developmental Neuroscience, vol. 72, pp. 1-5. https://doi.org/10.1016/j.ijdevneu.2018.10.002

Saldarriaga, Wilmar ; Salcedo-Arellano, María J. ; Rodriguez-Guerrero, Tatiana ; Ríos, Marcela ; Fandiño-Losada, Andrés ; Ramirez-Cheyne, Julian ; Lein, Pamela J ; Tassone, Flora ; Hagerman, Randi J. / Increased severity of fragile X spectrum disorders in the agricultural community of Ricaurte, Colombia. In: International Journal of Developmental Neuroscience. 2019 ; Vol. 72. pp. 1-5.

@article{f12be726d55a4898be0187dae3d38646,

title = "Increased severity of fragile X spectrum disorders in the agricultural community of Ricaurte, Colombia",

abstract = "Premutation carriers of the FMR1 gene (CGG repeats between 55 and 200) usually have normal intellectual abilities but approximately 20% are diagnosed with developmental problems or autism spectrum disorder. Additionally, close to 50% have psychiatric problems such as anxiety, ADHD and/or depression. The spectrum of fragile X disorders also includes Fragile-X-associated primary ovarian insufficiency (FXPOI) in female carriers and Fragile-X-associated tremor/ataxia syndrome (FXTAS) in older male and female carriers. We evaluated 25 premutation carriers in the rural community of Ricaurte Colombia and documented all behavioral problems, social deficits and clinical signs of FXPOI and FXTAS as well as reviewed the medical and obstetric history. We found an increased frequency and severity of symptoms of fragile X spectrum disorders, which might be related to the vulnerability of FMR1 premutation carriers to higher exposure to neurotoxic pesticides in this rural community.",

keywords = "Colombia, Fragile X spectrum disorders, Fragile X syndrome, FXPOI, FXTAS",

author = "Wilmar Saldarriaga and Salcedo-Arellano, {Mar{\'i}a J.} and Tatiana Rodriguez-Guerrero and Marcela R{\'i}os and Andr{\'e}s Fandi{\~n}o-Losada and Julian Ramirez-Cheyne and Lein, {Pamela J} and Flora Tassone and Hagerman, {Randi J}",

year = "2019",

month = feb,

day = "1",

doi = "10.1016/j.ijdevneu.2018.10.002",

language = "English (US)",

volume = "72",

pages = "1--5",

journal = "International Journal of Developmental Neuroscience",

issn = "0736-5748",

publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Increased severity of fragile X spectrum disorders in the agricultural community of Ricaurte, Colombia

AU - Saldarriaga, Wilmar

AU - Salcedo-Arellano, María J.

AU - Rodriguez-Guerrero, Tatiana

AU - Ríos, Marcela

AU - Fandiño-Losada, Andrés

AU - Ramirez-Cheyne, Julian

AU - Lein, Pamela J

AU - Tassone, Flora

AU - Hagerman, Randi J

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Premutation carriers of the FMR1 gene (CGG repeats between 55 and 200) usually have normal intellectual abilities but approximately 20% are diagnosed with developmental problems or autism spectrum disorder. Additionally, close to 50% have psychiatric problems such as anxiety, ADHD and/or depression. The spectrum of fragile X disorders also includes Fragile-X-associated primary ovarian insufficiency (FXPOI) in female carriers and Fragile-X-associated tremor/ataxia syndrome (FXTAS) in older male and female carriers. We evaluated 25 premutation carriers in the rural community of Ricaurte Colombia and documented all behavioral problems, social deficits and clinical signs of FXPOI and FXTAS as well as reviewed the medical and obstetric history. We found an increased frequency and severity of symptoms of fragile X spectrum disorders, which might be related to the vulnerability of FMR1 premutation carriers to higher exposure to neurotoxic pesticides in this rural community.

AB - Premutation carriers of the FMR1 gene (CGG repeats between 55 and 200) usually have normal intellectual abilities but approximately 20% are diagnosed with developmental problems or autism spectrum disorder. Additionally, close to 50% have psychiatric problems such as anxiety, ADHD and/or depression. The spectrum of fragile X disorders also includes Fragile-X-associated primary ovarian insufficiency (FXPOI) in female carriers and Fragile-X-associated tremor/ataxia syndrome (FXTAS) in older male and female carriers. We evaluated 25 premutation carriers in the rural community of Ricaurte Colombia and documented all behavioral problems, social deficits and clinical signs of FXPOI and FXTAS as well as reviewed the medical and obstetric history. We found an increased frequency and severity of symptoms of fragile X spectrum disorders, which might be related to the vulnerability of FMR1 premutation carriers to higher exposure to neurotoxic pesticides in this rural community.

KW - Colombia

KW - Fragile X spectrum disorders

KW - Fragile X syndrome

KW - FXPOI

KW - FXTAS

UR - http://www.scopus.com/inward/record.url?scp=85056774162&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85056774162&partnerID=8YFLogxK

U2 - 10.1016/j.ijdevneu.2018.10.002

DO - 10.1016/j.ijdevneu.2018.10.002

M3 - Article

C2 - 30385191

AN - SCOPUS:85056774162

VL - 72

SP - 1

EP - 5

JO - International Journal of Developmental Neuroscience

JF - International Journal of Developmental Neuroscience

SN - 0736-5748

ER -