Increased serum d-lactate associated with diabetic ketoacidosis

Mary M Christopher, John D. Broussard, Carol W. Fallin, Nicolette J. Drost, Mark E. Peterson

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

We hypothesized that serum d-lactate may be increased in vivo in diabetes mellitus as a result of increased glucose flux through the glyoxalase pathway and/or via hepatic ketone metabolism. Levels of d-lactate and related metabolic intermediates were measured in 30 cats with spontaneous diabetes mellitus and in one ketoacidotic nondiabetic cat. Serum d-lactate was significantly (P = .0051) elevated in cats with ketoacidosis (337.2 ± 70.2 μmol/L) as compared with nonketoacidotic diabetic (140.3 ± 58.8) and control (25.0 + 6.5) cats. Two nonketoacidotic cats also had high levels of d-lactate. There was a significant linear correlation (r = .684, P = .0001) between d-lactate and β-hydroxybutyrate concentrations. Serum d-lactate did not correlate with serum glucose (r = .078, P = .6825), and in vitro erythrocyte d-lactate formation did not increase in the presence of hyperglycemia. These data suggest that hepatic ketone metabolism, rather than hyperglycemia, may be a major source of serum d-lactate in diabetics.

Original languageEnglish (US)
Pages (from-to)287-290
Number of pages4
JournalMetabolism
Volume44
Issue number3
DOIs
StatePublished - 1995
Externally publishedYes

Fingerprint

Diabetic Ketoacidosis
Lactic Acid
Cats
Serum
Ketones
Hyperglycemia
Diabetes Mellitus
Hydroxybutyrates
Glucose
Ketosis
Liver
Erythrocytes

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Christopher, M. M., Broussard, J. D., Fallin, C. W., Drost, N. J., & Peterson, M. E. (1995). Increased serum d-lactate associated with diabetic ketoacidosis. Metabolism, 44(3), 287-290. https://doi.org/10.1016/0026-0495(95)90156-6

Increased serum d-lactate associated with diabetic ketoacidosis. / Christopher, Mary M; Broussard, John D.; Fallin, Carol W.; Drost, Nicolette J.; Peterson, Mark E.

In: Metabolism, Vol. 44, No. 3, 1995, p. 287-290.

Research output: Contribution to journalArticle

Christopher, MM, Broussard, JD, Fallin, CW, Drost, NJ & Peterson, ME 1995, 'Increased serum d-lactate associated with diabetic ketoacidosis', Metabolism, vol. 44, no. 3, pp. 287-290. https://doi.org/10.1016/0026-0495(95)90156-6
Christopher, Mary M ; Broussard, John D. ; Fallin, Carol W. ; Drost, Nicolette J. ; Peterson, Mark E. / Increased serum d-lactate associated with diabetic ketoacidosis. In: Metabolism. 1995 ; Vol. 44, No. 3. pp. 287-290.
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