Increased serum concentrations of adiponectin in canine hypothyroidism

Michal Mazaki-Tovi, Sarah K. Abood, Amir Kol, Amnon Farkas, Patricia A. Schenck

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Serum concentrations of adiponectin were compared between sex-matched hypothyroid (n = 18) and euthyroid (n = 18) client-owned dogs with comparable ages and body condition scores (BCS). Concentrations of adiponectin (mean; 95% confidence interval) were significantly (P < 0.01) higher in hypothyroid (17.2 μg/mL; 12.1-20.5 μg/mL) than healthy (8.0 μg/mL; 5.6-11.4 μg/mL) dogs following adjustment for potential confounders (BCS, age and sex). Serum concentrations of adiponectin were significantly negatively associated with concentrations of total thyroxine (P < 0.05) and positively correlated with concentrations of cholesterol (r = 0.6, P < 0.01) in hypothyroid dogs. In conclusion, this study demonstrated increased serum concentrations of adiponectin in dogs with hypothyroidism. Suggestive of the presence of resistance to adiponectin that could have contributed to development of hyperlipidemia and insulin resistance in these dogs or alternatively, could be a consequence of these metabolic alterations.

Original languageEnglish (US)
Pages (from-to)253-255
Number of pages3
JournalVeterinary Journal
Volume203
Issue number2
DOIs
StatePublished - Feb 1 2015

Keywords

  • Adiponectin
  • Canine
  • Hyperlipidaemia
  • Hypothyroidism
  • Obesity

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)
  • Medicine(all)

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