Increased ratio of tumor necrosis factor-α to interleukin-10 production is associated with Schistosoma haematobium-induced urinary-tract morbidity

Alex N. Wamachi, Jyoti S. Mayadev, Peter L. Mungai, Phillip L. Magak, John H. Ouma, Japhet K. Magambo, Eric M. Muchiri, Davy K. Koech, Charles H. King, Christopher L. King

Research output: Contribution to journalArticle

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Abstract

Bladder and kidney disease, which affect ∼25%-30% of subjects infected with Schistosoma haematobium, are mediated by T cell-dependent granulomatous responses to schistosome eggs. To determine why only some infected subjects develop disease, we examined the hypothesis that infected Kenyan subjects with ultrasound-detected urinary-tract morbidity (n = 49) had dysregulated cytokine production leading to enhanced granulomatous responses, compared with subjects of similar age and intensity of infection without morbidity (n = 100). Peripheral blood mononuclear cells from subjects with morbidity produced 8-fold greater levels of egg antigen-driven tumor necrosis factor (TNF)-α and had a 99-fold greater mean TNF-α:interleukin (IL)-10 ratio, compared with subjects without disease. No differences in cytokine response to non-egg-derived schistosome antigens were observed between groups. Subjects with morbidity had increased TNF-α production in response to endotoxin, suggesting an innate hyperresponsiveness. These results indicate that increased TNF-α production, relative to that of IL-10, is associated with developing bladder-wall morbidity with S. haematobium infection.

Original languageEnglish (US)
Pages (from-to)2020-2030
Number of pages11
JournalJournal of Infectious Diseases
Volume190
Issue number11
DOIs
StatePublished - Dec 1 2004
Externally publishedYes

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Schistosoma haematobium
Urinary Tract
Interleukin-10
Tumor Necrosis Factor-alpha
Morbidity
Urinary Bladder Diseases
Cytokines
Antigens
Kidney Diseases
Infection
Endotoxins
Eggs
Ovum
Blood Cells
Urinary Bladder
T-Lymphocytes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Wamachi, A. N., Mayadev, J. S., Mungai, P. L., Magak, P. L., Ouma, J. H., Magambo, J. K., ... King, C. L. (2004). Increased ratio of tumor necrosis factor-α to interleukin-10 production is associated with Schistosoma haematobium-induced urinary-tract morbidity. Journal of Infectious Diseases, 190(11), 2020-2030. https://doi.org/10.1086/425579

Increased ratio of tumor necrosis factor-α to interleukin-10 production is associated with Schistosoma haematobium-induced urinary-tract morbidity. / Wamachi, Alex N.; Mayadev, Jyoti S.; Mungai, Peter L.; Magak, Phillip L.; Ouma, John H.; Magambo, Japhet K.; Muchiri, Eric M.; Koech, Davy K.; King, Charles H.; King, Christopher L.

In: Journal of Infectious Diseases, Vol. 190, No. 11, 01.12.2004, p. 2020-2030.

Research output: Contribution to journalArticle

Wamachi, AN, Mayadev, JS, Mungai, PL, Magak, PL, Ouma, JH, Magambo, JK, Muchiri, EM, Koech, DK, King, CH & King, CL 2004, 'Increased ratio of tumor necrosis factor-α to interleukin-10 production is associated with Schistosoma haematobium-induced urinary-tract morbidity', Journal of Infectious Diseases, vol. 190, no. 11, pp. 2020-2030. https://doi.org/10.1086/425579
Wamachi, Alex N. ; Mayadev, Jyoti S. ; Mungai, Peter L. ; Magak, Phillip L. ; Ouma, John H. ; Magambo, Japhet K. ; Muchiri, Eric M. ; Koech, Davy K. ; King, Charles H. ; King, Christopher L. / Increased ratio of tumor necrosis factor-α to interleukin-10 production is associated with Schistosoma haematobium-induced urinary-tract morbidity. In: Journal of Infectious Diseases. 2004 ; Vol. 190, No. 11. pp. 2020-2030.
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