Abstract
Inflammation and asthma have both been reported in some children with autism spectrum disorder (ASD). To further assess this connection, peripheral immune cells isolated from young children with ASD and typically developing (TD) controls and the production of cytokines IL-17, -13, and -4 assessed following ex vivo mitogen stimulation. Notably, IL-17 production was significantly higher following stimulation in ASD children compared to controls. Moreover, IL-17 was increased in ASD children with co-morbid asthma compared to controls with the same condition. In conclusion, children with ASD exhibited a differential response to T cell stimulation with elevated IL-17 production compared to controls.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 33-41 |
| Number of pages | 9 |
| Journal | Journal of Neuroimmunology |
| Volume | 286 |
| DOIs | |
| State | Published - Sep 15 2015 |
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Keywords
- Asthma
- Autism
- Food allergies
- IL-17
ASJC Scopus subject areas
- Immunology
- Clinical Neurology
- Immunology and Allergy
- Neurology
Cite this
Increased production of IL-17 in children with autism spectrum disorders and co-morbid asthma. / Akintunde, Marjannie Eloi; Rose, Melissa; Krakowiak, Paula; Heuer, Luke; Ashwood, Paul; Hansen, Robin L; Hertz-Picciotto, Irva; Van de Water, Judith A.
In: Journal of Neuroimmunology, Vol. 286, 15.09.2015, p. 33-41.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Increased production of IL-17 in children with autism spectrum disorders and co-morbid asthma
AU - Akintunde, Marjannie Eloi
AU - Rose, Melissa
AU - Krakowiak, Paula
AU - Heuer, Luke
AU - Ashwood, Paul
AU - Hansen, Robin L
AU - Hertz-Picciotto, Irva
AU - Van de Water, Judith A
PY - 2015/9/15
Y1 - 2015/9/15
N2 - Inflammation and asthma have both been reported in some children with autism spectrum disorder (ASD). To further assess this connection, peripheral immune cells isolated from young children with ASD and typically developing (TD) controls and the production of cytokines IL-17, -13, and -4 assessed following ex vivo mitogen stimulation. Notably, IL-17 production was significantly higher following stimulation in ASD children compared to controls. Moreover, IL-17 was increased in ASD children with co-morbid asthma compared to controls with the same condition. In conclusion, children with ASD exhibited a differential response to T cell stimulation with elevated IL-17 production compared to controls.
AB - Inflammation and asthma have both been reported in some children with autism spectrum disorder (ASD). To further assess this connection, peripheral immune cells isolated from young children with ASD and typically developing (TD) controls and the production of cytokines IL-17, -13, and -4 assessed following ex vivo mitogen stimulation. Notably, IL-17 production was significantly higher following stimulation in ASD children compared to controls. Moreover, IL-17 was increased in ASD children with co-morbid asthma compared to controls with the same condition. In conclusion, children with ASD exhibited a differential response to T cell stimulation with elevated IL-17 production compared to controls.
KW - Asthma
KW - Autism
KW - Food allergies
KW - IL-17
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UR - http://www.scopus.com/inward/citedby.url?scp=84939493493&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2015.07.003
DO - 10.1016/j.jneuroim.2015.07.003
M3 - Article
VL - 286
SP - 33
EP - 41
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
ER -