Increased production of IL-17 in children with autism spectrum disorders and co-morbid asthma

Marjannie Eloi Akintunde, Melissa Rose, Paula Krakowiak, Luke Heuer, Paul Ashwood, Robin L Hansen, Irva Hertz-Picciotto, Judith A Van de Water

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Inflammation and asthma have both been reported in some children with autism spectrum disorder (ASD). To further assess this connection, peripheral immune cells isolated from young children with ASD and typically developing (TD) controls and the production of cytokines IL-17, -13, and -4 assessed following ex vivo mitogen stimulation. Notably, IL-17 production was significantly higher following stimulation in ASD children compared to controls. Moreover, IL-17 was increased in ASD children with co-morbid asthma compared to controls with the same condition. In conclusion, children with ASD exhibited a differential response to T cell stimulation with elevated IL-17 production compared to controls.

Original languageEnglish (US)
Pages (from-to)33-41
Number of pages9
JournalJournal of Neuroimmunology
Volume286
DOIs
StatePublished - Sep 15 2015

Keywords

  • Asthma
  • Autism
  • Food allergies
  • IL-17

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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