Increased production of IL-17 in children with autism spectrum disorders and co-morbid asthma

Marjannie Eloi Akintunde; Melissa Rose; Paula Krakowiak; Luke Heuer; Paul Ashwood; Robin L Hansen; Irva Hertz-Picciotto; Judith A Van de Water

doi:10.1016/j.jneuroim.2015.07.003

Increased production of IL-17 in children with autism spectrum disorders and co-morbid asthma

Marjannie Eloi Akintunde, Melissa Rose, Paula Krakowiak, Luke Heuer, Paul Ashwood, Robin L Hansen, Irva Hertz-Picciotto, Judith A Van de Water

Research output: Contribution to journal › Article

34 Scopus citations

Abstract

Inflammation and asthma have both been reported in some children with autism spectrum disorder (ASD). To further assess this connection, peripheral immune cells isolated from young children with ASD and typically developing (TD) controls and the production of cytokines IL-17, -13, and -4 assessed following ex vivo mitogen stimulation. Notably, IL-17 production was significantly higher following stimulation in ASD children compared to controls. Moreover, IL-17 was increased in ASD children with co-morbid asthma compared to controls with the same condition. In conclusion, children with ASD exhibited a differential response to T cell stimulation with elevated IL-17 production compared to controls.

Original language	English (US)
Pages (from-to)	33-41
Number of pages	9
Journal	Journal of Neuroimmunology
Volume	286
DOIs	https://doi.org/10.1016/j.jneuroim.2015.07.003
State	Published - Sep 15 2015

Keywords

Asthma
Autism
Food allergies
IL-17

ASJC Scopus subject areas

Immunology
Clinical Neurology
Immunology and Allergy
Neurology

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Akintunde, M. E., Rose, M., Krakowiak, P., Heuer, L., Ashwood, P., Hansen, R. L., Hertz-Picciotto, I., & Van de Water, J. A. (2015). Increased production of IL-17 in children with autism spectrum disorders and co-morbid asthma. Journal of Neuroimmunology, 286, 33-41. https://doi.org/10.1016/j.jneuroim.2015.07.003

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abstract = "Inflammation and asthma have both been reported in some children with autism spectrum disorder (ASD). To further assess this connection, peripheral immune cells isolated from young children with ASD and typically developing (TD) controls and the production of cytokines IL-17, -13, and -4 assessed following ex vivo mitogen stimulation. Notably, IL-17 production was significantly higher following stimulation in ASD children compared to controls. Moreover, IL-17 was increased in ASD children with co-morbid asthma compared to controls with the same condition. In conclusion, children with ASD exhibited a differential response to T cell stimulation with elevated IL-17 production compared to controls.",

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AU - Ashwood, Paul

AU - Hansen, Robin L

AU - Hertz-Picciotto, Irva

AU - Van de Water, Judith A

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AB - Inflammation and asthma have both been reported in some children with autism spectrum disorder (ASD). To further assess this connection, peripheral immune cells isolated from young children with ASD and typically developing (TD) controls and the production of cytokines IL-17, -13, and -4 assessed following ex vivo mitogen stimulation. Notably, IL-17 production was significantly higher following stimulation in ASD children compared to controls. Moreover, IL-17 was increased in ASD children with co-morbid asthma compared to controls with the same condition. In conclusion, children with ASD exhibited a differential response to T cell stimulation with elevated IL-17 production compared to controls.

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