Abstract
Maternal-fetal cellular trafficking (MFCT) during pregnancy leads to the presence of maternal cells in the fetus and of fetal cells in the mother. Since this process may be altered in cases of pregnancy complications, we asked whether open fetal surgery leads to changes in microchimerism levels. We analyzed maternal and fetal microchimerism in fetuses who underwent open fetal surgery for repair of spina bifida and compared their levels to patients who had postnatal repair and to healthy controls. We found that maternal microchimerism levels were increased in patients who had open fetal surgery compared with controls. In contrast, patients who had fetal intervention at the time of delivery did not demonstrate increased microchimerism. These results suggest that open fetal surgery may alter trafficking. Given the importance of MFCT in maternal-fetal tolerance, we discuss potential implications for the field of preterm labor and transplantation tolerance.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-3 |
| Number of pages | 3 |
| Journal | Chimerism |
| Volume | 3 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 1 2012 |
| Externally published | Yes |
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Keywords
- Fetal surgery
- Maternal-fetal cellular trafficking
- Microchimerism
- Myelomeningocele
- Spina bifida
ASJC Scopus subject areas
- Medicine(all)
- Biochemistry
- Biochemistry, Genetics and Molecular Biology (miscellaneous)
- Molecular Biology
- Genetics
Cite this
Increased maternal microchimerism after open fetal surgery. / Saadai, Payam; MacKenzie, Tippi C.
In: Chimerism, Vol. 3, No. 3, 01.01.2012, p. 1-3.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Increased maternal microchimerism after open fetal surgery
AU - Saadai, Payam
AU - MacKenzie, Tippi C.
PY - 2012/1/1
Y1 - 2012/1/1
N2 - Maternal-fetal cellular trafficking (MFCT) during pregnancy leads to the presence of maternal cells in the fetus and of fetal cells in the mother. Since this process may be altered in cases of pregnancy complications, we asked whether open fetal surgery leads to changes in microchimerism levels. We analyzed maternal and fetal microchimerism in fetuses who underwent open fetal surgery for repair of spina bifida and compared their levels to patients who had postnatal repair and to healthy controls. We found that maternal microchimerism levels were increased in patients who had open fetal surgery compared with controls. In contrast, patients who had fetal intervention at the time of delivery did not demonstrate increased microchimerism. These results suggest that open fetal surgery may alter trafficking. Given the importance of MFCT in maternal-fetal tolerance, we discuss potential implications for the field of preterm labor and transplantation tolerance.
AB - Maternal-fetal cellular trafficking (MFCT) during pregnancy leads to the presence of maternal cells in the fetus and of fetal cells in the mother. Since this process may be altered in cases of pregnancy complications, we asked whether open fetal surgery leads to changes in microchimerism levels. We analyzed maternal and fetal microchimerism in fetuses who underwent open fetal surgery for repair of spina bifida and compared their levels to patients who had postnatal repair and to healthy controls. We found that maternal microchimerism levels were increased in patients who had open fetal surgery compared with controls. In contrast, patients who had fetal intervention at the time of delivery did not demonstrate increased microchimerism. These results suggest that open fetal surgery may alter trafficking. Given the importance of MFCT in maternal-fetal tolerance, we discuss potential implications for the field of preterm labor and transplantation tolerance.
KW - Fetal surgery
KW - Maternal-fetal cellular trafficking
KW - Microchimerism
KW - Myelomeningocele
KW - Spina bifida
UR - http://www.scopus.com/inward/record.url?scp=84871243822&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84871243822&partnerID=8YFLogxK
U2 - 10.4161/chim.22277
DO - 10.4161/chim.22277
M3 - Article
C2 - 22992682
AN - SCOPUS:84871243822
VL - 3
SP - 1
EP - 3
JO - Chimerism
JF - Chimerism
SN - 1938-1956
IS - 3
ER -