Increased levels of CD34+ cells are associated in patients with abdominal aortic aneurysms compared with patients with peripheral vascular disease

Elyse N. Van Spyk, Kevin C. Chun, Kiana M. Samadzadeh, John H. Peters, Eugene S Lee

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Background: Circulating progenitor cells are integral to vascular health and effectively predict vascular reactivity. CD34 is a known marker of circulating progenitor cells. Few studies have examined the role of CD34+ cells in abdominal aortic aneurysm(AAA) disease and peripheral vascular disease (PVD). The aim of this study was to compare the percentage of CD34+ cells between patients with AAA versus PVD. Materials and methods: We collected peripheral whole blood from AAA or PVD patients. The blood was stained with fluorescently labeled antibodies against CD34 or isotype controls. We collected data using a flow cytometer and analyzed them. We also recorded risk factors such as hypertension, diabetes, total cholesterol, serum white blood cells, serum creatinine, body mass index, blood pressure, statin use, current smoking status, coronary artery disease, cerebral vascular accident, and chronic obstructive pulmonary disease. Results: We enrolled 24 patients in this study (AAA, n = 12; PVD, n = 12). The AAA patients had a greater percentage of CD34+ cells compared with PVD patients. (r = 0.84; P = 0.016). There were no significant risk factors differences between AAA and PVD patients. Conclusions: Based on CD34+ cell counts, AAA is a less severe vascular disease than PVD. Whether CD34+ cells can serve as a biomarker for risk stratification or a potential therapy warrants further study.

Original languageEnglish (US)
Pages (from-to)638-643
Number of pages6
JournalJournal of Surgical Research
Volume184
Issue number1
DOIs
StatePublished - 2013

Keywords

  • Abdominal aortic aneurysm
  • CD34
  • Circulating progenitor cells
  • Endothelial progenitor cells
  • Flow cytometry
  • Peripheral vascular disease

ASJC Scopus subject areas

  • Surgery

Fingerprint Dive into the research topics of 'Increased levels of CD34+ cells are associated in patients with abdominal aortic aneurysms compared with patients with peripheral vascular disease'. Together they form a unique fingerprint.

  • Cite this