Increased Galectin-1 Expression in Thymic Epithelial Tumors

Jonathan Riess; Christina S. Kong; Robert B. West; Sukhmani K. Padda; Joel W. Neal; Heather A. Wakelee; Quynh Thu Le

doi:10.1016/j.cllc.2018.12.005

Increased Galectin-1 Expression in Thymic Epithelial Tumors

Jonathan Riess, Christina S. Kong, Robert B. West, Sukhmani K. Padda, Joel W. Neal, Heather A. Wakelee, Quynh Thu Le

Hematology and Oncology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Thymic malignancies are rare tumors where lack of preclinical models adversely affect development of new therapies. Galectin-1 is an important protein in cancer involved in maintaining an immunosuppressive environment. This study examined galectin-1 expression in a large thymic epithelial tumor issue microarray and found elevated expression compared to benign thymus controls. Galectin-1 is a potential therapeutic target in thymic malignancies.

Original language	English (US)
Journal	Clinical Lung Cancer
DOIs	https://doi.org/10.1016/j.cllc.2018.12.005
State	Published - Jan 1 2019

Keywords

Thymic malignancy
Tumor microenvironment

ASJC Scopus subject areas

Oncology
Pulmonary and Respiratory Medicine
Cancer Research

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10.1016/j.cllc.2018.12.005

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abstract = "Thymic malignancies are rare tumors where lack of preclinical models adversely affect development of new therapies. Galectin-1 is an important protein in cancer involved in maintaining an immunosuppressive environment. This study examined galectin-1 expression in a large thymic epithelial tumor issue microarray and found elevated expression compared to benign thymus controls. Galectin-1 is a potential therapeutic target in thymic malignancies.",

keywords = "Thymic malignancy, Tumor microenvironment",

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