Increased Galectin-1 Expression in Thymic Epithelial Tumors

Jonathan Riess, Christina S. Kong, Robert B. West, Sukhmani K. Padda, Joel W. Neal, Heather A. Wakelee, Quynh Thu Le

Research output: Contribution to journalArticle

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Abstract

Thymic malignancies are rare tumors where lack of preclinical models adversely affect development of new therapies. Galectin-1 is an important protein in cancer involved in maintaining an immunosuppressive environment. This study examined galectin-1 expression in a large thymic epithelial tumor issue microarray and found elevated expression compared to benign thymus controls. Galectin-1 is a potential therapeutic target in thymic malignancies.

Original languageEnglish (US)
JournalClinical Lung Cancer
DOIs
StatePublished - Jan 1 2019

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Keywords

  • Thymic malignancy
  • Tumor microenvironment

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

Cite this

Riess, J., Kong, C. S., West, R. B., Padda, S. K., Neal, J. W., Wakelee, H. A., & Le, Q. T. (2019). Increased Galectin-1 Expression in Thymic Epithelial Tumors. Clinical Lung Cancer. https://doi.org/10.1016/j.cllc.2018.12.005