Abstract
Thymic malignancies are rare tumors where lack of preclinical models adversely affect development of new therapies. Galectin-1 is an important protein in cancer involved in maintaining an immunosuppressive environment. This study examined galectin-1 expression in a large thymic epithelial tumor issue microarray and found elevated expression compared to benign thymus controls. Galectin-1 is a potential therapeutic target in thymic malignancies.
| Original language | English (US) |
|---|---|
| Journal | Clinical Lung Cancer |
| DOIs | |
| State | Published - Jan 1 2019 |
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Keywords
- Thymic malignancy
- Tumor microenvironment
ASJC Scopus subject areas
- Oncology
- Pulmonary and Respiratory Medicine
- Cancer Research
Cite this
Increased Galectin-1 Expression in Thymic Epithelial Tumors. / Riess, Jonathan; Kong, Christina S.; West, Robert B.; Padda, Sukhmani K.; Neal, Joel W.; Wakelee, Heather A.; Le, Quynh Thu.
In: Clinical Lung Cancer, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Increased Galectin-1 Expression in Thymic Epithelial Tumors
AU - Riess, Jonathan
AU - Kong, Christina S.
AU - West, Robert B.
AU - Padda, Sukhmani K.
AU - Neal, Joel W.
AU - Wakelee, Heather A.
AU - Le, Quynh Thu
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Thymic malignancies are rare tumors where lack of preclinical models adversely affect development of new therapies. Galectin-1 is an important protein in cancer involved in maintaining an immunosuppressive environment. This study examined galectin-1 expression in a large thymic epithelial tumor issue microarray and found elevated expression compared to benign thymus controls. Galectin-1 is a potential therapeutic target in thymic malignancies.
AB - Thymic malignancies are rare tumors where lack of preclinical models adversely affect development of new therapies. Galectin-1 is an important protein in cancer involved in maintaining an immunosuppressive environment. This study examined galectin-1 expression in a large thymic epithelial tumor issue microarray and found elevated expression compared to benign thymus controls. Galectin-1 is a potential therapeutic target in thymic malignancies.
KW - Thymic malignancy
KW - Tumor microenvironment
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UR - http://www.scopus.com/inward/citedby.url?scp=85061433479&partnerID=8YFLogxK
U2 - 10.1016/j.cllc.2018.12.005
DO - 10.1016/j.cllc.2018.12.005
M3 - Article
C2 - 30773448
AN - SCOPUS:85061433479
JO - Clinical Lung Cancer
JF - Clinical Lung Cancer
SN - 1525-7304
ER -