Increased frequency of HL A8 in Sjogren's syndrome

M. Eric Gershwin, P. I. Terasaki, R. Graw, T. M. Chused

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Abstract

The histocompatibility antigen, HL A8, was found to be elevated in patients with Sjogren's syndrome. Among 28 patients, the frequency of HL A8 was 58% compared to 21% among controls (P<0.001 after correction). With the addition of this disorder to the list of other autoimmune diseases associated with HL A8, it now seems possible to postulate a single basis autoimmune defect gene in high linkage disequilibrium with HL A8.

Original languageEnglish (US)
Pages (from-to)342-346
Number of pages5
JournalTissue Antigens
Volume6
Issue number5
StatePublished - 1975
Externally publishedYes

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ASJC Scopus subject areas

  • Cell Biology
  • Immunology

Cite this

Gershwin, M. E., Terasaki, P. I., Graw, R., & Chused, T. M. (1975). Increased frequency of HL A8 in Sjogren's syndrome. Tissue Antigens, 6(5), 342-346.