Abstract
The vagal afferent pathway is important in short-term regulation of food intake, and decreased activation of this neural pathway with long-term ingestion of a high-fat diet may contribute to hyperphagic weight gain. We tested the hypothesis that expression of genes encoding receptors for orexigenic factors in vagal afferent neurons are increased by long-term ingestion of a high-fat diet, thus supporting orexigenic signals from the gut. Obesity-prone (DIO-P) rats fed a high-fat diet showed increased body weight and hyperleptinemia compared with low-fat diet-fed controls and high-fat diet-induced obesity-resistant (DIO-R) rats. Expression of the type I cannabinoid receptor and growth hormone secretagogue receptor 1a in the nodose ganglia was increased in DIO-P compared with low-fat diet-fed controls or DIO-R rats. Shifts in the balance between orexigenic and anorexigenic signals within the vagal afferent pathway may influence food intake and body weight gain induced by high fat diets.
| Original language | English (US) |
|---|---|
| Journal | American Journal of Physiology - Endocrinology and Metabolism |
| Volume | 296 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 2009 |
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Keywords
- Cholecystokinin
- Diet-induced obesity
- Ghrelin
ASJC Scopus subject areas
- Physiology
- Physiology (medical)
- Endocrinology, Diabetes and Metabolism
Cite this
Increased expression of receptors for orexigenic factors in nodose ganglion of diet-induced obese rats. / Paulino, Gabriel; De La Serre, Claire Barbier; Knotts, Trina A.; Oort, Pieter J.; Newman, John W.; Adams, Sean H.; Raybould, Helen E.
In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 296, No. 4, 04.2009.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Increased expression of receptors for orexigenic factors in nodose ganglion of diet-induced obese rats
AU - Paulino, Gabriel
AU - De La Serre, Claire Barbier
AU - Knotts, Trina A.
AU - Oort, Pieter J.
AU - Newman, John W.
AU - Adams, Sean H.
AU - Raybould, Helen E
PY - 2009/4
Y1 - 2009/4
N2 - The vagal afferent pathway is important in short-term regulation of food intake, and decreased activation of this neural pathway with long-term ingestion of a high-fat diet may contribute to hyperphagic weight gain. We tested the hypothesis that expression of genes encoding receptors for orexigenic factors in vagal afferent neurons are increased by long-term ingestion of a high-fat diet, thus supporting orexigenic signals from the gut. Obesity-prone (DIO-P) rats fed a high-fat diet showed increased body weight and hyperleptinemia compared with low-fat diet-fed controls and high-fat diet-induced obesity-resistant (DIO-R) rats. Expression of the type I cannabinoid receptor and growth hormone secretagogue receptor 1a in the nodose ganglia was increased in DIO-P compared with low-fat diet-fed controls or DIO-R rats. Shifts in the balance between orexigenic and anorexigenic signals within the vagal afferent pathway may influence food intake and body weight gain induced by high fat diets.
AB - The vagal afferent pathway is important in short-term regulation of food intake, and decreased activation of this neural pathway with long-term ingestion of a high-fat diet may contribute to hyperphagic weight gain. We tested the hypothesis that expression of genes encoding receptors for orexigenic factors in vagal afferent neurons are increased by long-term ingestion of a high-fat diet, thus supporting orexigenic signals from the gut. Obesity-prone (DIO-P) rats fed a high-fat diet showed increased body weight and hyperleptinemia compared with low-fat diet-fed controls and high-fat diet-induced obesity-resistant (DIO-R) rats. Expression of the type I cannabinoid receptor and growth hormone secretagogue receptor 1a in the nodose ganglia was increased in DIO-P compared with low-fat diet-fed controls or DIO-R rats. Shifts in the balance between orexigenic and anorexigenic signals within the vagal afferent pathway may influence food intake and body weight gain induced by high fat diets.
KW - Cholecystokinin
KW - Diet-induced obesity
KW - Ghrelin
UR - http://www.scopus.com/inward/record.url?scp=65649151443&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=65649151443&partnerID=8YFLogxK
U2 - 10.1152/ajpendo.90796.2008
DO - 10.1152/ajpendo.90796.2008
M3 - Article
C2 - 19190260
AN - SCOPUS:65649151443
VL - 296
JO - American Journal of Physiology - Renal Fluid and Electrolyte Physiology
JF - American Journal of Physiology - Renal Fluid and Electrolyte Physiology
SN - 1931-857X
IS - 4
ER -