Increased expression of receptors for orexigenic factors in nodose ganglion of diet-induced obese rats

Gabriel Paulino, Claire Barbier De La Serre, Trina A. Knotts, Pieter J. Oort, John W. Newman, Sean H. Adams, Helen E Raybould

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

The vagal afferent pathway is important in short-term regulation of food intake, and decreased activation of this neural pathway with long-term ingestion of a high-fat diet may contribute to hyperphagic weight gain. We tested the hypothesis that expression of genes encoding receptors for orexigenic factors in vagal afferent neurons are increased by long-term ingestion of a high-fat diet, thus supporting orexigenic signals from the gut. Obesity-prone (DIO-P) rats fed a high-fat diet showed increased body weight and hyperleptinemia compared with low-fat diet-fed controls and high-fat diet-induced obesity-resistant (DIO-R) rats. Expression of the type I cannabinoid receptor and growth hormone secretagogue receptor 1a in the nodose ganglia was increased in DIO-P compared with low-fat diet-fed controls or DIO-R rats. Shifts in the balance between orexigenic and anorexigenic signals within the vagal afferent pathway may influence food intake and body weight gain induced by high fat diets.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume296
Issue number4
DOIs
StatePublished - Apr 2009

Fingerprint

Nodose Ganglion
High Fat Diet
Diet
Afferent Pathways
Fat-Restricted Diet
Obesity
Eating
Weight Gain
Body Weight
Ghrelin Receptor
Appetite Regulation
Afferent Neurons
Neural Pathways
Cannabinoid Receptors
Gene Expression

Keywords

  • Cholecystokinin
  • Diet-induced obesity
  • Ghrelin

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Endocrinology, Diabetes and Metabolism

Cite this

Increased expression of receptors for orexigenic factors in nodose ganglion of diet-induced obese rats. / Paulino, Gabriel; De La Serre, Claire Barbier; Knotts, Trina A.; Oort, Pieter J.; Newman, John W.; Adams, Sean H.; Raybould, Helen E.

In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 296, No. 4, 04.2009.

Research output: Contribution to journalArticle

Paulino, Gabriel ; De La Serre, Claire Barbier ; Knotts, Trina A. ; Oort, Pieter J. ; Newman, John W. ; Adams, Sean H. ; Raybould, Helen E. / Increased expression of receptors for orexigenic factors in nodose ganglion of diet-induced obese rats. In: American Journal of Physiology - Endocrinology and Metabolism. 2009 ; Vol. 296, No. 4.
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