Increased CXCL8 (IL-8) expression in Multiple Sclerosis

Brett T. Lund, Nazely Ashikian, Huy Q. Ta, Yervand Chakryan, Krikor Manoukian, Susan Groshen, Wendy Gilmore, Gurtej S. Cheema, William Stohl, Margaret E. Burnett, David Ko, Norman J. Kachuck, Leslie P. Weiner

Research output: Contribution to journalArticle

86 Scopus citations

Abstract

Multiple Sclerosis (MS) is a chronic inflammatory disease of the CNS which is characterized by large mononuclear cell infiltration and significant demyelination. CXCL8 is a chemo-attractant for both neutrophils and monocytes and triggers their firm adhesion to endothelium. In this study, we demonstrate that serum CXCL8 and CXCL8 secretion from PBMCs are significantly higher in untreated MS patients compared to controls and are significantly reduced in MS patients receiving interferon-β1a therapy. We suggest that CXCL8 may serve as a marker of monocyte activity in MS and may play a role in monocyte recruitment to the CNS.

Original languageEnglish (US)
Pages (from-to)161-171
Number of pages11
JournalJournal of Neuroimmunology
Volume155
Issue number1-2
DOIs
StatePublished - Oct 2004

Keywords

  • CXCL8
  • Inflammation
  • Interferon-β1a
  • Monocytes
  • Multiple Sclerosis

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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  • Cite this

    Lund, B. T., Ashikian, N., Ta, H. Q., Chakryan, Y., Manoukian, K., Groshen, S., Gilmore, W., Cheema, G. S., Stohl, W., Burnett, M. E., Ko, D., Kachuck, N. J., & Weiner, L. P. (2004). Increased CXCL8 (IL-8) expression in Multiple Sclerosis. Journal of Neuroimmunology, 155(1-2), 161-171. https://doi.org/10.1016/j.jneuroim.2004.06.008