Increased activation of anterior paralimbic and executive cortex from waking to rapid eye movement sleep in depression

Eric A. Nofzinger, Daniel J. Buysse, Anne Germain, Cameron S Carter, Beatriz Luna, Julie C. Price, Carolyn C. Meltzer, Jean M. Miewald, Charles F. Reynolds, David J. Kupfer

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

Background: Depression is associated with sleep disturbances, including alterations in rapid eye movement (REM) sleep, that may relate to the neurobiology of the disorder. Given that REM sleep activates limbic and anterior paralimbic cortex and that depressed patients demonstrate increases in electroencephalographic sleep measures of REM, we hypothesized greater activation of these structures during waking to REM sleep in depressed patients. Design: Subjects completed electroencephalographic sleep and regional cerebral glucose metabolism assessments during both waking and REM sleep using [ 18F] fluoro-2-deoxy-D-glucose positron emission tomography. Setting: Patients and healthy subjects recruited from the general community to participate in a research study of depression at an academic medical center. Patients: Twenty-four unmedicated patients who met the Structured Clinical Interview for DSM-IV criteria for current major depression and who had a score of 15 or higher on a 17-item Hamilton Rating Scale for Depression; 14 medically healthy subjects of comparable age and sex who were free of mental disorders. Main Outcome Measures: Electroencephalographic sleep, semiquantitative and relative regional cerebral metabolism during waking and REM sleep. Results: Depressed patients showed greater REM sleep percentages. While both healthy and depressed patients activated anterior paralimbic structures from waking to REM sleep, the spatial extent of this activation was greater in the depressed patients. Additionally, depressed patients showed greater activation in bilateral dorsolateral prefrontal, left premotor, primary sensorimotor, and left parietal cortices, as well as in the midbrain reticular formation. Conclusions: Increased anterior paralimbic activation from waking to REM sleep may be related to affective dysregulation in depressed patients. Increased activation of executive cortex may be related to a cognitive dysregulation. These results suggest that altered function of limbic/anterior paralimbic and prefrontal circuits in depression is accentuated during the REM sleep state. The characteristic sleep disturbances of depression may reflect this dysregulation.

Original languageEnglish (US)
Pages (from-to)695-702
Number of pages8
JournalArchives of General Psychiatry
Volume61
Issue number7
DOIs
StatePublished - Jul 2004

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REM Sleep
Sleep
Depression
Healthy Volunteers
Parietal Lobe
Neurobiology
Deoxyglucose
Mental Disorders
Diagnostic and Statistical Manual of Mental Disorders
Positron-Emission Tomography

ASJC Scopus subject areas

  • Psychiatry and Mental health

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Increased activation of anterior paralimbic and executive cortex from waking to rapid eye movement sleep in depression. / Nofzinger, Eric A.; Buysse, Daniel J.; Germain, Anne; Carter, Cameron S; Luna, Beatriz; Price, Julie C.; Meltzer, Carolyn C.; Miewald, Jean M.; Reynolds, Charles F.; Kupfer, David J.

In: Archives of General Psychiatry, Vol. 61, No. 7, 07.2004, p. 695-702.

Research output: Contribution to journalArticle

Nofzinger, EA, Buysse, DJ, Germain, A, Carter, CS, Luna, B, Price, JC, Meltzer, CC, Miewald, JM, Reynolds, CF & Kupfer, DJ 2004, 'Increased activation of anterior paralimbic and executive cortex from waking to rapid eye movement sleep in depression', Archives of General Psychiatry, vol. 61, no. 7, pp. 695-702. https://doi.org/10.1001/archpsyc.61.7.695
Nofzinger, Eric A. ; Buysse, Daniel J. ; Germain, Anne ; Carter, Cameron S ; Luna, Beatriz ; Price, Julie C. ; Meltzer, Carolyn C. ; Miewald, Jean M. ; Reynolds, Charles F. ; Kupfer, David J. / Increased activation of anterior paralimbic and executive cortex from waking to rapid eye movement sleep in depression. In: Archives of General Psychiatry. 2004 ; Vol. 61, No. 7. pp. 695-702.
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abstract = "Background: Depression is associated with sleep disturbances, including alterations in rapid eye movement (REM) sleep, that may relate to the neurobiology of the disorder. Given that REM sleep activates limbic and anterior paralimbic cortex and that depressed patients demonstrate increases in electroencephalographic sleep measures of REM, we hypothesized greater activation of these structures during waking to REM sleep in depressed patients. Design: Subjects completed electroencephalographic sleep and regional cerebral glucose metabolism assessments during both waking and REM sleep using [ 18F] fluoro-2-deoxy-D-glucose positron emission tomography. Setting: Patients and healthy subjects recruited from the general community to participate in a research study of depression at an academic medical center. Patients: Twenty-four unmedicated patients who met the Structured Clinical Interview for DSM-IV criteria for current major depression and who had a score of 15 or higher on a 17-item Hamilton Rating Scale for Depression; 14 medically healthy subjects of comparable age and sex who were free of mental disorders. Main Outcome Measures: Electroencephalographic sleep, semiquantitative and relative regional cerebral metabolism during waking and REM sleep. Results: Depressed patients showed greater REM sleep percentages. While both healthy and depressed patients activated anterior paralimbic structures from waking to REM sleep, the spatial extent of this activation was greater in the depressed patients. Additionally, depressed patients showed greater activation in bilateral dorsolateral prefrontal, left premotor, primary sensorimotor, and left parietal cortices, as well as in the midbrain reticular formation. Conclusions: Increased anterior paralimbic activation from waking to REM sleep may be related to affective dysregulation in depressed patients. Increased activation of executive cortex may be related to a cognitive dysregulation. These results suggest that altered function of limbic/anterior paralimbic and prefrontal circuits in depression is accentuated during the REM sleep state. The characteristic sleep disturbances of depression may reflect this dysregulation.",
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AU - Luna, Beatriz

AU - Price, Julie C.

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N2 - Background: Depression is associated with sleep disturbances, including alterations in rapid eye movement (REM) sleep, that may relate to the neurobiology of the disorder. Given that REM sleep activates limbic and anterior paralimbic cortex and that depressed patients demonstrate increases in electroencephalographic sleep measures of REM, we hypothesized greater activation of these structures during waking to REM sleep in depressed patients. Design: Subjects completed electroencephalographic sleep and regional cerebral glucose metabolism assessments during both waking and REM sleep using [ 18F] fluoro-2-deoxy-D-glucose positron emission tomography. Setting: Patients and healthy subjects recruited from the general community to participate in a research study of depression at an academic medical center. Patients: Twenty-four unmedicated patients who met the Structured Clinical Interview for DSM-IV criteria for current major depression and who had a score of 15 or higher on a 17-item Hamilton Rating Scale for Depression; 14 medically healthy subjects of comparable age and sex who were free of mental disorders. Main Outcome Measures: Electroencephalographic sleep, semiquantitative and relative regional cerebral metabolism during waking and REM sleep. Results: Depressed patients showed greater REM sleep percentages. While both healthy and depressed patients activated anterior paralimbic structures from waking to REM sleep, the spatial extent of this activation was greater in the depressed patients. Additionally, depressed patients showed greater activation in bilateral dorsolateral prefrontal, left premotor, primary sensorimotor, and left parietal cortices, as well as in the midbrain reticular formation. Conclusions: Increased anterior paralimbic activation from waking to REM sleep may be related to affective dysregulation in depressed patients. Increased activation of executive cortex may be related to a cognitive dysregulation. These results suggest that altered function of limbic/anterior paralimbic and prefrontal circuits in depression is accentuated during the REM sleep state. The characteristic sleep disturbances of depression may reflect this dysregulation.

AB - Background: Depression is associated with sleep disturbances, including alterations in rapid eye movement (REM) sleep, that may relate to the neurobiology of the disorder. Given that REM sleep activates limbic and anterior paralimbic cortex and that depressed patients demonstrate increases in electroencephalographic sleep measures of REM, we hypothesized greater activation of these structures during waking to REM sleep in depressed patients. Design: Subjects completed electroencephalographic sleep and regional cerebral glucose metabolism assessments during both waking and REM sleep using [ 18F] fluoro-2-deoxy-D-glucose positron emission tomography. Setting: Patients and healthy subjects recruited from the general community to participate in a research study of depression at an academic medical center. Patients: Twenty-four unmedicated patients who met the Structured Clinical Interview for DSM-IV criteria for current major depression and who had a score of 15 or higher on a 17-item Hamilton Rating Scale for Depression; 14 medically healthy subjects of comparable age and sex who were free of mental disorders. Main Outcome Measures: Electroencephalographic sleep, semiquantitative and relative regional cerebral metabolism during waking and REM sleep. Results: Depressed patients showed greater REM sleep percentages. While both healthy and depressed patients activated anterior paralimbic structures from waking to REM sleep, the spatial extent of this activation was greater in the depressed patients. Additionally, depressed patients showed greater activation in bilateral dorsolateral prefrontal, left premotor, primary sensorimotor, and left parietal cortices, as well as in the midbrain reticular formation. Conclusions: Increased anterior paralimbic activation from waking to REM sleep may be related to affective dysregulation in depressed patients. Increased activation of executive cortex may be related to a cognitive dysregulation. These results suggest that altered function of limbic/anterior paralimbic and prefrontal circuits in depression is accentuated during the REM sleep state. The characteristic sleep disturbances of depression may reflect this dysregulation.

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