Increase in glutamate as a sensitive indicator of extracellular matrix integrity in peritumoral edema: A 3.0-tesla proton magnetic resonance spectroscopy study

Teruo Kimura, Masaki Ohkubo, Hironaka Igarashi, Ingrid Kwee, Tsutomu Nakada

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Object. The authors of previous studies based on diffusion tensor imaging have indicated that there are two types of peritumoral edema-namely, edema with preserved structural integrity of the glial matrix and edema with compromised glial matrix. The authors of this study hypothesized that functionality of the glutamate (Glu)-glutamine shuttle, a vital neuron-glia interaction, may be differentially affected by peritumoral edema. They tested this hypothesis using proton magnetic resonance (MR) spectroscopy on a 3.0-tesla system that is capable of quantifying Glu without need of editing. Methods. Twenty-three patients, each with a single brain tumor mass and peritumoral edema (nine high-grade gliomas, eight metastatic brain tumors, and six meningiomas), and nine healthy individuals participated in this study. Single-voxel proton MR imaging targeting the region of peritumoral edema was performed using a 3.0-tesla system. Glutamate levels in the peritumoral edema of nonglial tumors was significantly elevated (p < 0.01) compared with edema associated with glial tumors or normal white matter. The finding confirmed that peritumoral edema in nonglial tumors is distinct from that of glial tumors, as previously indicated in diffusion tensor imaging studies. The authors hypothesized that the former condition represents a compensatory increase in activities of the Glu-glutamine shuttle brought about by simple expansion of the extracellular space due to edema. Conclusions. The assessment of Glu concentrations in peritumoral edema using 3.0-tesla proton MR spectroscopy may be developed into an objective index of the structural integrity of the glial matrix.

Original languageEnglish (US)
Pages (from-to)609-613
Number of pages5
JournalJournal of Neurosurgery
Volume106
Issue number4
DOIs
StatePublished - Apr 2007
Externally publishedYes

Fingerprint

Extracellular Matrix
Glutamic Acid
Edema
Neuroglia
Diffusion Tensor Imaging
Glutamine
Brain Neoplasms
Neoplasms
Proton Magnetic Resonance Spectroscopy
Extracellular Space
Meningioma
Glioma
Protons
Magnetic Resonance Imaging
Neurons

Keywords

  • Extracellular matrix
  • Glia
  • Glutamate
  • Peritumoral edema
  • Proton magnetic resonance imaging
  • Vasogenic edema

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Increase in glutamate as a sensitive indicator of extracellular matrix integrity in peritumoral edema : A 3.0-tesla proton magnetic resonance spectroscopy study. / Kimura, Teruo; Ohkubo, Masaki; Igarashi, Hironaka; Kwee, Ingrid; Nakada, Tsutomu.

In: Journal of Neurosurgery, Vol. 106, No. 4, 04.2007, p. 609-613.

Research output: Contribution to journalArticle

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N2 - Object. The authors of previous studies based on diffusion tensor imaging have indicated that there are two types of peritumoral edema-namely, edema with preserved structural integrity of the glial matrix and edema with compromised glial matrix. The authors of this study hypothesized that functionality of the glutamate (Glu)-glutamine shuttle, a vital neuron-glia interaction, may be differentially affected by peritumoral edema. They tested this hypothesis using proton magnetic resonance (MR) spectroscopy on a 3.0-tesla system that is capable of quantifying Glu without need of editing. Methods. Twenty-three patients, each with a single brain tumor mass and peritumoral edema (nine high-grade gliomas, eight metastatic brain tumors, and six meningiomas), and nine healthy individuals participated in this study. Single-voxel proton MR imaging targeting the region of peritumoral edema was performed using a 3.0-tesla system. Glutamate levels in the peritumoral edema of nonglial tumors was significantly elevated (p < 0.01) compared with edema associated with glial tumors or normal white matter. The finding confirmed that peritumoral edema in nonglial tumors is distinct from that of glial tumors, as previously indicated in diffusion tensor imaging studies. The authors hypothesized that the former condition represents a compensatory increase in activities of the Glu-glutamine shuttle brought about by simple expansion of the extracellular space due to edema. Conclusions. The assessment of Glu concentrations in peritumoral edema using 3.0-tesla proton MR spectroscopy may be developed into an objective index of the structural integrity of the glial matrix.

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