Increase in aflatoxin exposure in two populations residing in East and West Texas, United States

Kathy S. Xue, Lili Tang, Chwan Li Shen, Bradley H. Pollock, Fernando Guerra, Timothy D. Phillips, Jia Sheng Wang

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Although aflatoxin (AF) exposure has not been recognized as a major problem in the United States and other developed nations, recent global climate change may have a profound impact on distribution of toxigenic fungi growth and production of AFs in grain and groundnuts. Alterations in the contamination pattern can increase human dietary exposure, and further invoke public health concerns and associated disease risks. In this study, two populations from East and West Texas, known for their high risk of liver cancer, were examined for their AF exposure at three different time periods from 2004 to 2014. Serum samples (n = 1124) were collected from participants recruited for various studies from Bexar County and Lubbock County, TX, over the span of 2004 through 2014. The exposure biomarker, serum AFB1-lysine adduct, was analyzed by HPLC-FLD and confirmed by LC-MS. Both populations showed a significant increase in detection rate, as well as median levels of serum AFB1-lysine adduct over time, from 2.35 to 4.34 pg/mg albumin in East Texas (2007–2014), and 0.63–3.98 pg/mg albumin in West Texas (2004–2010). This observed shift in exposure likely represents a shift in the AF contamination pattern in the State of Texas, and may warrant further studies on risk assessment for the potential etiological effects of such increased exposures.

Original languageEnglish (US)
Article number113662
JournalInternational Journal of Hygiene and Environmental Health
Volume231
DOIs
StatePublished - Jan 2021

Keywords

  • Aflatoxin B
  • Molecular epidemiology

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Fingerprint

Dive into the research topics of 'Increase in aflatoxin exposure in two populations residing in East and West Texas, United States'. Together they form a unique fingerprint.

Cite this