Incorporating alternative splicing and mRNA editing into the genetic analysis of complex traits

Musa A. Hassan, Jeroen Saeij

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The nomination of candidate genes underlying complex traits is often focused on genetic variations that alter mRNA abundance or result in non-conservative changes in amino acids. Although inconspicuous in complex trait analysis, genetic variants that affect splicing or RNA editing can also generate proteomic diversity and impact genetic traits. Indeed, it is known that splicing and RNA editing modulate several traits in humans and model organisms. Using high-throughput RNA sequencing (RNA-seq) analysis, it is now possible to integrate the genetics of transcript abundance, alternative splicing (AS) and editing with the analysis of complex traits. We recently demonstrated that both AS and mRNA editing are modulated by genetic and environmental factors, and potentially engender phenotypic diversity in a genetically segregating mouse population. Therefore, the analysis of splicing and RNA editing can expand not only the regulatory landscape of transcriptome and proteome complexity, but also the repertoire of candidate genes for complex traits.

Original languageEnglish (US)
Pages (from-to)1032-1040
Number of pages9
JournalBioEssays
Volume36
Issue number11
DOIs
StatePublished - Nov 1 2014
Externally publishedYes

Keywords

  • Alternative splicing
  • Quantitative genetics
  • RNA editing

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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