Incidence of mild cognitive impairment in the Pittsburgh Cardiovascular Health Study-Cognition Study

Oscar L. Lopez, James T. Becker, Yue Fang Chang, Robert A. Sweet, Steven T. DeKosky, Michael H. Gach, Owen T. Carmichael, Eric McDade, Lewis H. Kuller

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Objectives and Methods: The purpose of this study was to examine the incidence of mild cognitive impairment (MCI) and patterns of progression from incident MCI to dementia in 285 cognitively normal subjects (mean age, 78.9 years) in the Cardiovascular Health Study-Cognition Study from 1998-1999 to 2010-2011. Results: Two hundred (70%) of the participants progressed to MCI; the age-adjusted incidence of MCI was 111.09 (95% confidence interval, 88.13-142.95) per 1,000 person-years. A total of 107 (53.5%) of the incident MCI subjects progressed to dementia. The mean time from MCI to dementia was 2.8 ± 1.8 years. Forty (20%) of the incident MCI cases had an "unstable" course: 19 (9.5%) converted to MCI and later returned to normal; 10 (5%) converted to MCI, to normal, and later back to MCI; 7 (3.5%) converted to MCI, to normal, to MCI, and later to dementia; and 4 (2%) converted to MCI, to normal, and later to dementia. There was an increased mortality rate among the cognitively normal group (110.10 per 1,000 person-years) compared to those with incident MCI who converted to dementia (41.32 per 1,000 person-years). Conclusions: The majority of the subjects aged <80 years developed an MCI syndrome, and half of them progressed to dementia. Once the MCI syndrome was present, the symptoms of dementia appeared within 2 to 3 years. Progression from normal to MCI or from normal to MCI to dementia is not always linear; subjects who developed MCI and later returned to normal can subsequently progress to dementia. Competing mortality and morbidity influence the study of incident MCI and dementia in population cohorts.

Original languageEnglish (US)
Pages (from-to)1599-1606
Number of pages8
JournalNeurology
Volume79
Issue number15
DOIs
StatePublished - Oct 9 2012

Fingerprint

Cognition
Incidence
Health
Dementia
Cognitive Dysfunction
Mild Cognitive Impairment
Pittsburgh
Mortality

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

Cite this

Lopez, O. L., Becker, J. T., Chang, Y. F., Sweet, R. A., DeKosky, S. T., Gach, M. H., ... Kuller, L. H. (2012). Incidence of mild cognitive impairment in the Pittsburgh Cardiovascular Health Study-Cognition Study. Neurology, 79(15), 1599-1606. https://doi.org/10.1212/WNL.0b013e31826e25f0

Incidence of mild cognitive impairment in the Pittsburgh Cardiovascular Health Study-Cognition Study. / Lopez, Oscar L.; Becker, James T.; Chang, Yue Fang; Sweet, Robert A.; DeKosky, Steven T.; Gach, Michael H.; Carmichael, Owen T.; McDade, Eric; Kuller, Lewis H.

In: Neurology, Vol. 79, No. 15, 09.10.2012, p. 1599-1606.

Research output: Contribution to journalArticle

Lopez, OL, Becker, JT, Chang, YF, Sweet, RA, DeKosky, ST, Gach, MH, Carmichael, OT, McDade, E & Kuller, LH 2012, 'Incidence of mild cognitive impairment in the Pittsburgh Cardiovascular Health Study-Cognition Study', Neurology, vol. 79, no. 15, pp. 1599-1606. https://doi.org/10.1212/WNL.0b013e31826e25f0
Lopez, Oscar L. ; Becker, James T. ; Chang, Yue Fang ; Sweet, Robert A. ; DeKosky, Steven T. ; Gach, Michael H. ; Carmichael, Owen T. ; McDade, Eric ; Kuller, Lewis H. / Incidence of mild cognitive impairment in the Pittsburgh Cardiovascular Health Study-Cognition Study. In: Neurology. 2012 ; Vol. 79, No. 15. pp. 1599-1606.
@article{b4173080808c4593afc753c4148b60fa,
title = "Incidence of mild cognitive impairment in the Pittsburgh Cardiovascular Health Study-Cognition Study",
abstract = "Objectives and Methods: The purpose of this study was to examine the incidence of mild cognitive impairment (MCI) and patterns of progression from incident MCI to dementia in 285 cognitively normal subjects (mean age, 78.9 years) in the Cardiovascular Health Study-Cognition Study from 1998-1999 to 2010-2011. Results: Two hundred (70{\%}) of the participants progressed to MCI; the age-adjusted incidence of MCI was 111.09 (95{\%} confidence interval, 88.13-142.95) per 1,000 person-years. A total of 107 (53.5{\%}) of the incident MCI subjects progressed to dementia. The mean time from MCI to dementia was 2.8 ± 1.8 years. Forty (20{\%}) of the incident MCI cases had an {"}unstable{"} course: 19 (9.5{\%}) converted to MCI and later returned to normal; 10 (5{\%}) converted to MCI, to normal, and later back to MCI; 7 (3.5{\%}) converted to MCI, to normal, to MCI, and later to dementia; and 4 (2{\%}) converted to MCI, to normal, and later to dementia. There was an increased mortality rate among the cognitively normal group (110.10 per 1,000 person-years) compared to those with incident MCI who converted to dementia (41.32 per 1,000 person-years). Conclusions: The majority of the subjects aged <80 years developed an MCI syndrome, and half of them progressed to dementia. Once the MCI syndrome was present, the symptoms of dementia appeared within 2 to 3 years. Progression from normal to MCI or from normal to MCI to dementia is not always linear; subjects who developed MCI and later returned to normal can subsequently progress to dementia. Competing mortality and morbidity influence the study of incident MCI and dementia in population cohorts.",
author = "Lopez, {Oscar L.} and Becker, {James T.} and Chang, {Yue Fang} and Sweet, {Robert A.} and DeKosky, {Steven T.} and Gach, {Michael H.} and Carmichael, {Owen T.} and Eric McDade and Kuller, {Lewis H.}",
year = "2012",
month = "10",
day = "9",
doi = "10.1212/WNL.0b013e31826e25f0",
language = "English (US)",
volume = "79",
pages = "1599--1606",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "15",

}

TY - JOUR

T1 - Incidence of mild cognitive impairment in the Pittsburgh Cardiovascular Health Study-Cognition Study

AU - Lopez, Oscar L.

AU - Becker, James T.

AU - Chang, Yue Fang

AU - Sweet, Robert A.

AU - DeKosky, Steven T.

AU - Gach, Michael H.

AU - Carmichael, Owen T.

AU - McDade, Eric

AU - Kuller, Lewis H.

PY - 2012/10/9

Y1 - 2012/10/9

N2 - Objectives and Methods: The purpose of this study was to examine the incidence of mild cognitive impairment (MCI) and patterns of progression from incident MCI to dementia in 285 cognitively normal subjects (mean age, 78.9 years) in the Cardiovascular Health Study-Cognition Study from 1998-1999 to 2010-2011. Results: Two hundred (70%) of the participants progressed to MCI; the age-adjusted incidence of MCI was 111.09 (95% confidence interval, 88.13-142.95) per 1,000 person-years. A total of 107 (53.5%) of the incident MCI subjects progressed to dementia. The mean time from MCI to dementia was 2.8 ± 1.8 years. Forty (20%) of the incident MCI cases had an "unstable" course: 19 (9.5%) converted to MCI and later returned to normal; 10 (5%) converted to MCI, to normal, and later back to MCI; 7 (3.5%) converted to MCI, to normal, to MCI, and later to dementia; and 4 (2%) converted to MCI, to normal, and later to dementia. There was an increased mortality rate among the cognitively normal group (110.10 per 1,000 person-years) compared to those with incident MCI who converted to dementia (41.32 per 1,000 person-years). Conclusions: The majority of the subjects aged <80 years developed an MCI syndrome, and half of them progressed to dementia. Once the MCI syndrome was present, the symptoms of dementia appeared within 2 to 3 years. Progression from normal to MCI or from normal to MCI to dementia is not always linear; subjects who developed MCI and later returned to normal can subsequently progress to dementia. Competing mortality and morbidity influence the study of incident MCI and dementia in population cohorts.

AB - Objectives and Methods: The purpose of this study was to examine the incidence of mild cognitive impairment (MCI) and patterns of progression from incident MCI to dementia in 285 cognitively normal subjects (mean age, 78.9 years) in the Cardiovascular Health Study-Cognition Study from 1998-1999 to 2010-2011. Results: Two hundred (70%) of the participants progressed to MCI; the age-adjusted incidence of MCI was 111.09 (95% confidence interval, 88.13-142.95) per 1,000 person-years. A total of 107 (53.5%) of the incident MCI subjects progressed to dementia. The mean time from MCI to dementia was 2.8 ± 1.8 years. Forty (20%) of the incident MCI cases had an "unstable" course: 19 (9.5%) converted to MCI and later returned to normal; 10 (5%) converted to MCI, to normal, and later back to MCI; 7 (3.5%) converted to MCI, to normal, to MCI, and later to dementia; and 4 (2%) converted to MCI, to normal, and later to dementia. There was an increased mortality rate among the cognitively normal group (110.10 per 1,000 person-years) compared to those with incident MCI who converted to dementia (41.32 per 1,000 person-years). Conclusions: The majority of the subjects aged <80 years developed an MCI syndrome, and half of them progressed to dementia. Once the MCI syndrome was present, the symptoms of dementia appeared within 2 to 3 years. Progression from normal to MCI or from normal to MCI to dementia is not always linear; subjects who developed MCI and later returned to normal can subsequently progress to dementia. Competing mortality and morbidity influence the study of incident MCI and dementia in population cohorts.

UR - http://www.scopus.com/inward/record.url?scp=84867530149&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84867530149&partnerID=8YFLogxK

U2 - 10.1212/WNL.0b013e31826e25f0

DO - 10.1212/WNL.0b013e31826e25f0

M3 - Article

C2 - 23019262

AN - SCOPUS:84867530149

VL - 79

SP - 1599

EP - 1606

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 15

ER -