Incidence of dementia after age 90 in a multiracial cohort

Paola Gilsanz, Maria M. Corrada, Claudia H. Kawas, Elizabeth Rose Mayeda, M. Maria Glymour, Charles P. Quesenberry, Catherine Lee, Rachel Whitmer

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Introduction: Little is known about dementia incidence in diverse populations of oldest-old, the age group with highest dementia incidence. Methods: Incident dementia diagnoses from 1/1/2010 to 9/30/2015 were abstracted from medical records for 2350 members of an integrated health care system in California (n = 1702 whites, n = 375 blacks, n = 105 Latinos, n = 168 Asians) aged ≥90 in 2010. We estimated race/ethnicity-specific age-adjusted dementia incidence rates and implemented Cox proportional hazards models and Fine and Gray competing risk of death models adjusted for demographics and comorbidities in midlife and late-life. Results: Dementia incidence rates (n = 771 cases) were lowest among Asians (89.9/1000 person-years), followed by whites (96.9/1000 person-years), Latinos (105.8/1000 person-years), and blacks (121.5/1000 person-years). Cox regression and competing risk models estimated 28% and 36% higher dementia risk for blacks versus whites adjusting for demographics and comorbidities. Discussion: Patterns of racial/ethnic disparities in dementia seen in younger older adults continue after the age of 90 years, though smaller in magnitude.

Original languageEnglish (US)
Pages (from-to)497-505
Number of pages9
JournalAlzheimer's and Dementia
Volume15
Issue number4
DOIs
StatePublished - Apr 1 2019

Keywords

  • Dementia
  • Disparities
  • Epidemiology
  • Ethnicity
  • Oldest-old
  • Race

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health

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