TY - JOUR
T1 - Incidence of and risk factors for diabetes mellitus in cats that have undergone renal transplantation
T2 - 187 Cases (1986-2005)
AU - Case, Joseph B.
AU - Kyles, Andrew E.
AU - Nelson, Richard W
AU - Aronson, Lillian
AU - Kass, Philip H
AU - Klose, Tyler C.
AU - Bailiff, Nathan L.
AU - Gregory, Clare R.
PY - 2007/3/15
Y1 - 2007/3/15
N2 - Objective-To compare incidence of diabetes mellitus in cats that had undergone renal transplantation with incidence in cats with chronic renal failure, compare mortality rates in cats that underwent renal transplantation and did or did not develop diabetes mellitus, and identify potential risk factors for development of posttransplantation diabetes mellitus (PTDM) in cats. Design-Retrospective case series. Animals-187 cats that underwent renal transplantation. Procedures-Medical records were reviewed. Results-26 of the 187 (13.9%) cats developed PTDM, with the incidence of PTDM being 66 cases/1,000 cat years at risk. By contrast, the incidence of diabetes mellitus among a comparison population of 178 cats with chronic renal failure that did not undergo renal transplantation was 17.9 cases/1,000 cat years at risk, and cats that underwent renal transplantation were 5.45 times as likely to develop diabetes mellitus as were control cats with chronic renal failure. The mortality rate among cats with PTDM was 2.38 times the rate among cats that underwent renal transplantation but did not develop PTDM. Age, sex, body weight, and percentage change in body weight were not found to be significantly associated with development of PTDM. Conclusions and Clinical Relevance-Results suggest that cats that undergo renal transplantation have an increased risk of developing diabetes mellitus, compared with cats with chronic renal failure, and that mortality rate is higher for cats that develop PTDM than for cats that do not.
AB - Objective-To compare incidence of diabetes mellitus in cats that had undergone renal transplantation with incidence in cats with chronic renal failure, compare mortality rates in cats that underwent renal transplantation and did or did not develop diabetes mellitus, and identify potential risk factors for development of posttransplantation diabetes mellitus (PTDM) in cats. Design-Retrospective case series. Animals-187 cats that underwent renal transplantation. Procedures-Medical records were reviewed. Results-26 of the 187 (13.9%) cats developed PTDM, with the incidence of PTDM being 66 cases/1,000 cat years at risk. By contrast, the incidence of diabetes mellitus among a comparison population of 178 cats with chronic renal failure that did not undergo renal transplantation was 17.9 cases/1,000 cat years at risk, and cats that underwent renal transplantation were 5.45 times as likely to develop diabetes mellitus as were control cats with chronic renal failure. The mortality rate among cats with PTDM was 2.38 times the rate among cats that underwent renal transplantation but did not develop PTDM. Age, sex, body weight, and percentage change in body weight were not found to be significantly associated with development of PTDM. Conclusions and Clinical Relevance-Results suggest that cats that undergo renal transplantation have an increased risk of developing diabetes mellitus, compared with cats with chronic renal failure, and that mortality rate is higher for cats that develop PTDM than for cats that do not.
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U2 - 10.2460/javma.230.6.880
DO - 10.2460/javma.230.6.880
M3 - Article
C2 - 17362164
AN - SCOPUS:33947362820
VL - 230
SP - 880
EP - 884
JO - Journal of the American Veterinary Medical Association
JF - Journal of the American Veterinary Medical Association
SN - 0003-1488
IS - 6
ER -