Incidence of Alzheimer disease in a biracial urban community: Relation to apolipoprotein E allele status

Denis A. Evans, David A. Bennett, Robert S. Wilson, Julia L. Bienias, Martha Clare Morris, Paul A. Scherr, Liesi E. Hebert, Neelum Aggarwal, Laurel A Beckett, Rajiv Joglekar, Elizabeth Berry-Kravis, Julie Schneider

Research output: Contribution to journalArticle

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Abstract

Context: Few studies compare Alzheimer disease (AD) incidence among black and white subjects. Objective: To estimate incidence and the effect of the apolipoprotein E (APOE) ε4 allele in these races. Design: Population-based study of disease incidence using a random, stratified sample. Setting: A geographically defined community of 3 adjacent neighborhoods in Chicago, Ill. Participants: A total of 6158 persons (78.7% overall; 80.5% of the black subjects and 74.6% of the white subjects) participated; 4.1 years later, persons initially free of AD were sampled for clinical evaluation for disease incidence (overall 842 persons [74.8%] participated; 67.6% of the black subjects and 81.9% of the white subjects). Interventions: None. Main Outcome Measure: Incident, clinically diagnosed AD. Results: The effect of the APOE ε4 allele on the risk of AD differed strongly for black and white subjects. Among white subjects, the presence of the APOE ε4 allele was associated with a 2.73-fold (95% confidence interval [CI], 1.40-5.32) increase in risk while among black subjects there was no increase in risk (odds ratio, 1.02; 95% confidence interval, 0.39-2.68). Black race was associated with a nonsignificantly increased risk of AD with an odds ratio of 1.84 (95% CI, 0.734.66) if APOE and its interaction with race are considered, and an odds ratio of 1.28 (95% CI, 0.54-2.98) if they are not. The incidence of AD was 1.45% (95% CI, 0.89%-2.01%) per year among persons 65 to 74 years old, 4.73% (95% CI, 3.83%-5.64%) among those 75 to 84 years old, and 9.11% (95% CI, 7.36%-10.9%) among those 85 years and older. Conclusion: Apolipoprotein E ε4 led to increased risk of AD among white subjects but not black subjects.

Original languageEnglish (US)
Pages (from-to)185-189
Number of pages5
JournalArchives of Neurology
Volume60
Issue number2
DOIs
StatePublished - Feb 1 2003

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Community-Institutional Relations
Apolipoproteins E
Alzheimer Disease
Apolipoprotein E4
Alleles
Confidence Intervals
Incidence
Odds Ratio
Community Relations
Alzheimer's Disease
Confidence Interval
Allele
Cohort Studies
Outcome Assessment (Health Care)
Person

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Evans, D. A., Bennett, D. A., Wilson, R. S., Bienias, J. L., Morris, M. C., Scherr, P. A., ... Schneider, J. (2003). Incidence of Alzheimer disease in a biracial urban community: Relation to apolipoprotein E allele status. Archives of Neurology, 60(2), 185-189. https://doi.org/10.1001/archneur.60.2.185

Incidence of Alzheimer disease in a biracial urban community : Relation to apolipoprotein E allele status. / Evans, Denis A.; Bennett, David A.; Wilson, Robert S.; Bienias, Julia L.; Morris, Martha Clare; Scherr, Paul A.; Hebert, Liesi E.; Aggarwal, Neelum; Beckett, Laurel A; Joglekar, Rajiv; Berry-Kravis, Elizabeth; Schneider, Julie.

In: Archives of Neurology, Vol. 60, No. 2, 01.02.2003, p. 185-189.

Research output: Contribution to journalArticle

Evans, DA, Bennett, DA, Wilson, RS, Bienias, JL, Morris, MC, Scherr, PA, Hebert, LE, Aggarwal, N, Beckett, LA, Joglekar, R, Berry-Kravis, E & Schneider, J 2003, 'Incidence of Alzheimer disease in a biracial urban community: Relation to apolipoprotein E allele status', Archives of Neurology, vol. 60, no. 2, pp. 185-189. https://doi.org/10.1001/archneur.60.2.185
Evans, Denis A. ; Bennett, David A. ; Wilson, Robert S. ; Bienias, Julia L. ; Morris, Martha Clare ; Scherr, Paul A. ; Hebert, Liesi E. ; Aggarwal, Neelum ; Beckett, Laurel A ; Joglekar, Rajiv ; Berry-Kravis, Elizabeth ; Schneider, Julie. / Incidence of Alzheimer disease in a biracial urban community : Relation to apolipoprotein E allele status. In: Archives of Neurology. 2003 ; Vol. 60, No. 2. pp. 185-189.
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abstract = "Context: Few studies compare Alzheimer disease (AD) incidence among black and white subjects. Objective: To estimate incidence and the effect of the apolipoprotein E (APOE) ε4 allele in these races. Design: Population-based study of disease incidence using a random, stratified sample. Setting: A geographically defined community of 3 adjacent neighborhoods in Chicago, Ill. Participants: A total of 6158 persons (78.7{\%} overall; 80.5{\%} of the black subjects and 74.6{\%} of the white subjects) participated; 4.1 years later, persons initially free of AD were sampled for clinical evaluation for disease incidence (overall 842 persons [74.8{\%}] participated; 67.6{\%} of the black subjects and 81.9{\%} of the white subjects). Interventions: None. Main Outcome Measure: Incident, clinically diagnosed AD. Results: The effect of the APOE ε4 allele on the risk of AD differed strongly for black and white subjects. Among white subjects, the presence of the APOE ε4 allele was associated with a 2.73-fold (95{\%} confidence interval [CI], 1.40-5.32) increase in risk while among black subjects there was no increase in risk (odds ratio, 1.02; 95{\%} confidence interval, 0.39-2.68). Black race was associated with a nonsignificantly increased risk of AD with an odds ratio of 1.84 (95{\%} CI, 0.734.66) if APOE and its interaction with race are considered, and an odds ratio of 1.28 (95{\%} CI, 0.54-2.98) if they are not. The incidence of AD was 1.45{\%} (95{\%} CI, 0.89{\%}-2.01{\%}) per year among persons 65 to 74 years old, 4.73{\%} (95{\%} CI, 3.83{\%}-5.64{\%}) among those 75 to 84 years old, and 9.11{\%} (95{\%} CI, 7.36{\%}-10.9{\%}) among those 85 years and older. Conclusion: Apolipoprotein E ε4 led to increased risk of AD among white subjects but not black subjects.",
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AU - Evans, Denis A.

AU - Bennett, David A.

AU - Wilson, Robert S.

AU - Bienias, Julia L.

AU - Morris, Martha Clare

AU - Scherr, Paul A.

AU - Hebert, Liesi E.

AU - Aggarwal, Neelum

AU - Beckett, Laurel A

AU - Joglekar, Rajiv

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N2 - Context: Few studies compare Alzheimer disease (AD) incidence among black and white subjects. Objective: To estimate incidence and the effect of the apolipoprotein E (APOE) ε4 allele in these races. Design: Population-based study of disease incidence using a random, stratified sample. Setting: A geographically defined community of 3 adjacent neighborhoods in Chicago, Ill. Participants: A total of 6158 persons (78.7% overall; 80.5% of the black subjects and 74.6% of the white subjects) participated; 4.1 years later, persons initially free of AD were sampled for clinical evaluation for disease incidence (overall 842 persons [74.8%] participated; 67.6% of the black subjects and 81.9% of the white subjects). Interventions: None. Main Outcome Measure: Incident, clinically diagnosed AD. Results: The effect of the APOE ε4 allele on the risk of AD differed strongly for black and white subjects. Among white subjects, the presence of the APOE ε4 allele was associated with a 2.73-fold (95% confidence interval [CI], 1.40-5.32) increase in risk while among black subjects there was no increase in risk (odds ratio, 1.02; 95% confidence interval, 0.39-2.68). Black race was associated with a nonsignificantly increased risk of AD with an odds ratio of 1.84 (95% CI, 0.734.66) if APOE and its interaction with race are considered, and an odds ratio of 1.28 (95% CI, 0.54-2.98) if they are not. The incidence of AD was 1.45% (95% CI, 0.89%-2.01%) per year among persons 65 to 74 years old, 4.73% (95% CI, 3.83%-5.64%) among those 75 to 84 years old, and 9.11% (95% CI, 7.36%-10.9%) among those 85 years and older. Conclusion: Apolipoprotein E ε4 led to increased risk of AD among white subjects but not black subjects.

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