Inapparent carriers of simian acquired immune deficiency syndrome type D retrovirus and disease transmission with saliva

N. W. Lerche, K. G. Osborn, P. A. Marx, S. Prahalada, D. H. Maul, Linda J Lowenstine, R. J. Munn, M. L. Bryant, R. V. Henrickson, L. O. Arthur

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Simian acquired immune deficiency syndrome (SAIDS) type D retrovirus (SRV) was isolated from saliva, urine, and peripheral blood mononuclear cells of a 6-year-old healthy rhesus monkey (Macaca mulatta) seronegative for antibodies to human T-lymphotropic virus (HTLV) type I, HTLV type III, and simian T-lymphotropic virus type III (STLV-III), identified as an inapparent SAIDS carrier in retrospective epidemiologic studies. This animal was linked to 34 cases of SAIDS over a 3-year period. Two juvenile rhesus monkeys inoculated iv with the SRV-containing saliva from this carrier became persistently infected with the retrovirus and developed SAIDS after 4-6 weeks. Both animals seroconverted to SRV, but neither had detectable preinoculation or postinoculation antibodies against HTLV type I, HTLV type III, or STLV-III. One of these animals died of SAIDS with disseminated cytomegalovirus infection after 24 weeks, and the other remains alive with persistent SRV viremia, generalized lymphadenopathy, and splenomegaly after a transient immunosuppression. Major clinical and pathological features associated with the newly described STLV-III were not observed. SRV was subsequently identified in salive of 2 additional healthy carriers as well as monkeys with SAIDS. The findings of a carrier state in SAIDS and evidence for saliva transmission of the probable causative virus further support the usefulness of this animal model of nononcogenic immunosuppressive retroviral disease.

Original languageEnglish (US)
Pages (from-to)489-496
Number of pages8
JournalJournal of the National Cancer Institute
Issue number2
StatePublished - 1986

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


Dive into the research topics of 'Inapparent carriers of simian acquired immune deficiency syndrome type D retrovirus and disease transmission with saliva'. Together they form a unique fingerprint.

Cite this