Inapparent carriers of simian acquired immune deficiency syndrome type D retrovirus and disease transmission with saliva

N. W. Lerche, K. G. Osborn, P. A. Marx, S. Prahalada, D. H. Maul, Linda J Lowenstine, R. J. Munn, M. L. Bryant, R. V. Henrickson, L. O. Arthur

Research output: Contribution to journalArticle

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Abstract

Simian acquired immune deficiency syndrome (SAIDS) type D retrovirus (SRV) was isolated from saliva, urine, and peripheral blood mononuclear cells of a 6-year-old healthy rhesus monkey (Macaca mulatta) seronegative for antibodies to human T-lymphotropic virus (HTLV) type I, HTLV type III, and simian T-lymphotropic virus type III (STLV-III), identified as an inapparent SAIDS carrier in retrospective epidemiologic studies. This animal was linked to 34 cases of SAIDS over a 3-year period. Two juvenile rhesus monkeys inoculated iv with the SRV-containing saliva from this carrier became persistently infected with the retrovirus and developed SAIDS after 4-6 weeks. Both animals seroconverted to SRV, but neither had detectable preinoculation or postinoculation antibodies against HTLV type I, HTLV type III, or STLV-III. One of these animals died of SAIDS with disseminated cytomegalovirus infection after 24 weeks, and the other remains alive with persistent SRV viremia, generalized lymphadenopathy, and splenomegaly after a transient immunosuppression. Major clinical and pathological features associated with the newly described STLV-III were not observed. SRV was subsequently identified in salive of 2 additional healthy carriers as well as monkeys with SAIDS. The findings of a carrier state in SAIDS and evidence for saliva transmission of the probable causative virus further support the usefulness of this animal model of nononcogenic immunosuppressive retroviral disease.

Original languageEnglish (US)
Pages (from-to)489-496
Number of pages8
JournalJournal of the National Cancer Institute
Volume77
Issue number2
StatePublished - 1986

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Simian Acquired Immunodeficiency Syndrome
Betaretrovirus
Saliva
Viruses
Macaca mulatta
HIV
Carrier State
Antibodies
Viremia
Splenomegaly
Cytomegalovirus Infections
Retroviridae
Immunosuppressive Agents
Immunosuppression
Haplorhini
Epidemiologic Studies
Blood Cells
Animal Models
Retrospective Studies
Urine

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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Inapparent carriers of simian acquired immune deficiency syndrome type D retrovirus and disease transmission with saliva. / Lerche, N. W.; Osborn, K. G.; Marx, P. A.; Prahalada, S.; Maul, D. H.; Lowenstine, Linda J; Munn, R. J.; Bryant, M. L.; Henrickson, R. V.; Arthur, L. O.

In: Journal of the National Cancer Institute, Vol. 77, No. 2, 1986, p. 489-496.

Research output: Contribution to journalArticle

Lerche, NW, Osborn, KG, Marx, PA, Prahalada, S, Maul, DH, Lowenstine, LJ, Munn, RJ, Bryant, ML, Henrickson, RV & Arthur, LO 1986, 'Inapparent carriers of simian acquired immune deficiency syndrome type D retrovirus and disease transmission with saliva', Journal of the National Cancer Institute, vol. 77, no. 2, pp. 489-496.
Lerche, N. W. ; Osborn, K. G. ; Marx, P. A. ; Prahalada, S. ; Maul, D. H. ; Lowenstine, Linda J ; Munn, R. J. ; Bryant, M. L. ; Henrickson, R. V. ; Arthur, L. O. / Inapparent carriers of simian acquired immune deficiency syndrome type D retrovirus and disease transmission with saliva. In: Journal of the National Cancer Institute. 1986 ; Vol. 77, No. 2. pp. 489-496.
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abstract = "Simian acquired immune deficiency syndrome (SAIDS) type D retrovirus (SRV) was isolated from saliva, urine, and peripheral blood mononuclear cells of a 6-year-old healthy rhesus monkey (Macaca mulatta) seronegative for antibodies to human T-lymphotropic virus (HTLV) type I, HTLV type III, and simian T-lymphotropic virus type III (STLV-III), identified as an inapparent SAIDS carrier in retrospective epidemiologic studies. This animal was linked to 34 cases of SAIDS over a 3-year period. Two juvenile rhesus monkeys inoculated iv with the SRV-containing saliva from this carrier became persistently infected with the retrovirus and developed SAIDS after 4-6 weeks. Both animals seroconverted to SRV, but neither had detectable preinoculation or postinoculation antibodies against HTLV type I, HTLV type III, or STLV-III. One of these animals died of SAIDS with disseminated cytomegalovirus infection after 24 weeks, and the other remains alive with persistent SRV viremia, generalized lymphadenopathy, and splenomegaly after a transient immunosuppression. Major clinical and pathological features associated with the newly described STLV-III were not observed. SRV was subsequently identified in salive of 2 additional healthy carriers as well as monkeys with SAIDS. The findings of a carrier state in SAIDS and evidence for saliva transmission of the probable causative virus further support the usefulness of this animal model of nononcogenic immunosuppressive retroviral disease.",
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