Inadequate use and regulation of interventions against publication bias decreases their effectiveness: A systematic review

Kylie Thaler, Christina Kien, Barbara Nussbaumer, Megan G. Van Noord, Ursula Griebler, Irma Klerings, Gerald Gartlehner

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations


Objectives To determine the effectiveness of interventions designed to prevent or reduce publication and related biases. Study Design and Setting We searched multiple databases and performed manual searches using terms related to publication bias and known interventions against publication bias. We dually reviewed citations and assessed risk of bias. We synthesized results by intervention and outcomes measured and graded the quality of the evidence (QoE). Results We located 38 eligible studies. The use of prospective trial registries (PTR) has increased since 2005 (seven studies, moderate QoE); however, positive outcome-reporting bias is prevalent (14 studies, low QoE), and information in nonmandatory fields is vague (10 studies, low QoE). Disclosure of financial conflict of interest (CoI) is inadequate (five studies, low QoE). Blinding peer reviewers may reduce geographical bias (two studies, very low QoE), and open-access publishing does not discriminate against authors from low-income countries (two studies, very low QoE). Conclusion The use of PTR and CoI disclosures is increasing; however, the adequacy of their use requires improvement. The effect of open-access publication and blinding of peer reviewers on publication bias is unclear, as is the effect of other interventions such as electronic publication and authors' rights to publish their results.

Original languageEnglish (US)
Pages (from-to)792-802
Number of pages11
JournalJournal of Clinical Epidemiology
Issue number7
StatePublished - Jul 1 2015
Externally publishedYes


  • Conflict of interest
  • Geographical bias
  • Open access
  • Peer review
  • Publication bias
  • Trial registration

ASJC Scopus subject areas

  • Epidemiology


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