Inactivating adventitious viruses while preserving biological activity: Treating fetal bovine serum with pulsed ultraviolet light

Masoud Hosseini, Mary Sawyer, Carrie Schore, Joseph Vu, Krystyna Trzepla-Nabaglo, Cecilia Pina, Wayne Smith, Manuel Lagunas-Solar, Bennie Osburn

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

New evidence suggests the West Nile virus can be transmitted during blood transfusion from an asymptomatic donor. However, it is now possible to use pulsed ultraviolet laser light to inactivate viruses such as West Nile at large production scales. These experimental data show that using laser light on virus-treated media can render biological products free of contaminating viruses without compromising the biological activity essential to cell cultures.

Original languageEnglish (US)
Pages (from-to)35-40
Number of pages6
JournalBioPharm International
Volume15
Issue number12
StatePublished - Dec 1 2002

Fingerprint

Fetal Movement
Ultraviolet Rays
Viruses
Lasers
Serum
West Nile virus
Biological Products
Blood Transfusion
Cell Culture Techniques
Light

ASJC Scopus subject areas

  • Biotechnology
  • Pharmaceutical Science

Cite this

Hosseini, M., Sawyer, M., Schore, C., Vu, J., Trzepla-Nabaglo, K., Pina, C., ... Osburn, B. (2002). Inactivating adventitious viruses while preserving biological activity: Treating fetal bovine serum with pulsed ultraviolet light. BioPharm International, 15(12), 35-40.

Inactivating adventitious viruses while preserving biological activity : Treating fetal bovine serum with pulsed ultraviolet light. / Hosseini, Masoud; Sawyer, Mary; Schore, Carrie; Vu, Joseph; Trzepla-Nabaglo, Krystyna; Pina, Cecilia; Smith, Wayne; Lagunas-Solar, Manuel; Osburn, Bennie.

In: BioPharm International, Vol. 15, No. 12, 01.12.2002, p. 35-40.

Research output: Contribution to journalArticle

Hosseini, M, Sawyer, M, Schore, C, Vu, J, Trzepla-Nabaglo, K, Pina, C, Smith, W, Lagunas-Solar, M & Osburn, B 2002, 'Inactivating adventitious viruses while preserving biological activity: Treating fetal bovine serum with pulsed ultraviolet light', BioPharm International, vol. 15, no. 12, pp. 35-40.
Hosseini, Masoud ; Sawyer, Mary ; Schore, Carrie ; Vu, Joseph ; Trzepla-Nabaglo, Krystyna ; Pina, Cecilia ; Smith, Wayne ; Lagunas-Solar, Manuel ; Osburn, Bennie. / Inactivating adventitious viruses while preserving biological activity : Treating fetal bovine serum with pulsed ultraviolet light. In: BioPharm International. 2002 ; Vol. 15, No. 12. pp. 35-40.
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