Inaccurate projection of rat soleus motoneurons: A comparison of nerve repair techniques

Sue C. Bodine-Fowler, R. Scott Meyer, Alex Moskovitz, Reid Abrams, Michael J. Botte

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

The objectives of this study were 1) to determine the degree to which soleus motoneurons find their appropriate target following crush and transaction injuries to the sciatic nerve, and 2) to determine whether repair of a transacted nerve with a silicone tube leads to greater specificity of reinnervation and recovery of muscle function than the standard epineurial suture repair method. Sixty adult female Sprague-Dawley rats were randomly assigned to one of three sciatic nerve injury groups: crush injury, transection with epineurial suture repair, or transection with a silicone tube repair. The degree to which soleus motoneurons were able to find their appropriate target following a sciatic nerve injury was examined using a double labeling dye technique in which the original soleus motor pool was labeled with fast blue and reinnervating motoneurons were labeled with Dil. Soleus motoneurons were able to find their appropriate target following a crush injury. The accuracy of reinnervation following a transection injury and repair, however, was relatively poor. Only 14% of the original soleus motoneurons found the correct target following a transaction injury. Repair of a lesioned nerve with a silicone tube and a 5-mm gap as opposed to epineurial sutures did not increase the specificity of reinnervation or the degree of muscle recovery.

Original languageEnglish (US)
Pages (from-to)29-37
Number of pages9
JournalMuscle and Nerve
Volume20
Issue number1
DOIs
StatePublished - 1997

Keywords

  • denervation
  • reinnervation
  • silicone tube repair
  • specificity muscle adaptation

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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