In-Vivo Whole-Body Imaging of the Laboratory Mouse

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

The imaging sciences have revolutionized biomedical research by providing a means to see the inside of cells, tissues, and even whole organisms allowing structure and function to be interrogated and in many cases, permitting biologic events to be watched as they unfold. In biologic imaging, the light and electron microscopes are the primary tools, allowing studies at subcellular resolution. Such imaging studies, however, are largely confined to small organisms or studies at the level of excised or cultured cells. The advent of confocal and multiphoton microscopy, with biologically sensitive fluorescent probes, has further extended the range of measurements in terms of cell function and has led to improved spatial resolution and increased depth penetration in tissue. Cryoelectron microscopy together with powerful 3D reconstruction algorithms have allowed the structure of important macromolecular assemblies to be defined. Many opportunities exist to further improve the sensitivity, resolution, and quantitative ability of these imaging techniques, to reduce their cost, and to make them more accessible to biomedical researchers across a broad spectrum of research areas.

Original languageEnglish (US)
Title of host publicationThe Mouse in Biomedical Research
PublisherElsevier Inc.
Pages489-511
Number of pages23
Volume3
ISBN (Print)9780123694546
DOIs
StatePublished - 2007

Fingerprint

Whole Body Imaging
image analysis
Cryoelectron Microscopy
mice
Fluorescent Dyes
Confocal Microscopy
Biomedical Research
Cultured Cells
Research Personnel
Electrons
Light
Costs and Cost Analysis
biomedical research
organisms
light microscopes
electron microscopes
Research
cultured cells
probes (equipment)
microscopy

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Cherry, S. R. (2007). In-Vivo Whole-Body Imaging of the Laboratory Mouse. In The Mouse in Biomedical Research (Vol. 3, pp. 489-511). Elsevier Inc.. https://doi.org/10.1016/B978-012369454-6/50068-6

In-Vivo Whole-Body Imaging of the Laboratory Mouse. / Cherry, Simon R.

The Mouse in Biomedical Research. Vol. 3 Elsevier Inc., 2007. p. 489-511.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cherry, SR 2007, In-Vivo Whole-Body Imaging of the Laboratory Mouse. in The Mouse in Biomedical Research. vol. 3, Elsevier Inc., pp. 489-511. https://doi.org/10.1016/B978-012369454-6/50068-6
Cherry SR. In-Vivo Whole-Body Imaging of the Laboratory Mouse. In The Mouse in Biomedical Research. Vol. 3. Elsevier Inc. 2007. p. 489-511 https://doi.org/10.1016/B978-012369454-6/50068-6
Cherry, Simon R. / In-Vivo Whole-Body Imaging of the Laboratory Mouse. The Mouse in Biomedical Research. Vol. 3 Elsevier Inc., 2007. pp. 489-511
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