In vivo volumetric depth-resolved vasculature imaging of human limbus and sclera with 1 μm swept source phase-variance optical coherence angiography

Raju Poddar, Robert Zawadzki, Dennis E. Cortés, Mark J Mannis, John S Werner

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We present in vivo volumetric depth-resolved vasculature images of the anterior segment of the human eye acquired with phase-variance based motion contrast using a high-speed (100 kHz, 10<sup>5</sup> A-scans/s) swept source optical coherence tomography system (SSOCT). High phase stability SSOCT imaging was achieved by using a computationally efficient phase stabilization approach. The human corneo-scleral junction and sclera were imaged with swept source phase-variance optical coherence angiography and compared with slit lamp images from the same eyes of normal subjects. Different features of the rich vascular system in the conjunctiva and episclera were visualized and described. This system can be used as a potential tool for ophthalmological research to determine changes in the outflow system, which may be helpful for identification of abnormalities that lead to glaucoma.

Original languageEnglish (US)
Article number065301
JournalJournal of Optics (United Kingdom)
Volume17
Issue number6
DOIs
StatePublished - Jun 1 2015

Fingerprint

Angiography
angiography
Optical tomography
Imaging techniques
Phase stability
conjunctiva
tomography
Electric lamps
glaucoma
Imaging systems
cardiovascular system
Stabilization
abnormalities
luminaires
slits
stabilization
high speed

Keywords

  • imaging systems
  • medical and biological imaging
  • ophthalmology
  • optical coherence tomography

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials

Cite this

@article{e304f78741a14aed98735332e9ff0e26,
title = "In vivo volumetric depth-resolved vasculature imaging of human limbus and sclera with 1 μm swept source phase-variance optical coherence angiography",
abstract = "We present in vivo volumetric depth-resolved vasculature images of the anterior segment of the human eye acquired with phase-variance based motion contrast using a high-speed (100 kHz, 105 A-scans/s) swept source optical coherence tomography system (SSOCT). High phase stability SSOCT imaging was achieved by using a computationally efficient phase stabilization approach. The human corneo-scleral junction and sclera were imaged with swept source phase-variance optical coherence angiography and compared with slit lamp images from the same eyes of normal subjects. Different features of the rich vascular system in the conjunctiva and episclera were visualized and described. This system can be used as a potential tool for ophthalmological research to determine changes in the outflow system, which may be helpful for identification of abnormalities that lead to glaucoma.",
keywords = "imaging systems, medical and biological imaging, ophthalmology, optical coherence tomography",
author = "Raju Poddar and Robert Zawadzki and Cort{\'e}s, {Dennis E.} and Mannis, {Mark J} and Werner, {John S}",
year = "2015",
month = "6",
day = "1",
doi = "10.1088/2040-8978/17/6/065301",
language = "English (US)",
volume = "17",
journal = "Journal of Optics (United Kingdom)",
issn = "2040-8978",
publisher = "IOP Publishing Ltd.",
number = "6",

}

TY - JOUR

T1 - In vivo volumetric depth-resolved vasculature imaging of human limbus and sclera with 1 μm swept source phase-variance optical coherence angiography

AU - Poddar, Raju

AU - Zawadzki, Robert

AU - Cortés, Dennis E.

AU - Mannis, Mark J

AU - Werner, John S

PY - 2015/6/1

Y1 - 2015/6/1

N2 - We present in vivo volumetric depth-resolved vasculature images of the anterior segment of the human eye acquired with phase-variance based motion contrast using a high-speed (100 kHz, 105 A-scans/s) swept source optical coherence tomography system (SSOCT). High phase stability SSOCT imaging was achieved by using a computationally efficient phase stabilization approach. The human corneo-scleral junction and sclera were imaged with swept source phase-variance optical coherence angiography and compared with slit lamp images from the same eyes of normal subjects. Different features of the rich vascular system in the conjunctiva and episclera were visualized and described. This system can be used as a potential tool for ophthalmological research to determine changes in the outflow system, which may be helpful for identification of abnormalities that lead to glaucoma.

AB - We present in vivo volumetric depth-resolved vasculature images of the anterior segment of the human eye acquired with phase-variance based motion contrast using a high-speed (100 kHz, 105 A-scans/s) swept source optical coherence tomography system (SSOCT). High phase stability SSOCT imaging was achieved by using a computationally efficient phase stabilization approach. The human corneo-scleral junction and sclera were imaged with swept source phase-variance optical coherence angiography and compared with slit lamp images from the same eyes of normal subjects. Different features of the rich vascular system in the conjunctiva and episclera were visualized and described. This system can be used as a potential tool for ophthalmological research to determine changes in the outflow system, which may be helpful for identification of abnormalities that lead to glaucoma.

KW - imaging systems

KW - medical and biological imaging

KW - ophthalmology

KW - optical coherence tomography

UR - http://www.scopus.com/inward/record.url?scp=84930959909&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930959909&partnerID=8YFLogxK

U2 - 10.1088/2040-8978/17/6/065301

DO - 10.1088/2040-8978/17/6/065301

M3 - Article

AN - SCOPUS:84930959909

VL - 17

JO - Journal of Optics (United Kingdom)

JF - Journal of Optics (United Kingdom)

SN - 2040-8978

IS - 6

M1 - 065301

ER -