In vivo structural studies of the hippocampus in normal aging and in incipient Alzheimer's disease

M. J. De Leon, A. Convit, A. E. George, J. Golomb, S. De Santi, C. Tarshish, H. Rusinek, Matthew Bobinski, C. Ince, D. Miller, H. Wisniewsk

Research output: Contribution to journalArticle

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Abstract

Population trends indicate that in the near future the size of the elderly population will increase. This will result in a large increment in the numbers of persons suffering mild to severe levels of cognitive impairment. While considerable efforts continue to be made to explain brain changes associated with Alzheimer disease (AD), little is known of the brain changes in aging without dementia or so-called normal aging. Pathologic studies suggest that the medial temporal lobe is informative in the examination of the early brain changes related to AD. However, pathologic studies only offer a single observation and considerable uncertainty exists regarding the likelihood of progression of disease and the development of dementia. Several structural neuroimaging studies have recently investigated this anatomy and recent reports are encouraging for a medial temporal lobe based diagnosis for age-related cognitive impairments. We will present our findings on the MRI anatomy of the hippocampal formation as well as data bearing on the use of hippocampal formation imaging in the diagnosis of AD and as a predictive marker for future dementia. Our findings suggest an anatomically specific relationship between hippocampal volume and secondary memory performance. Because these observations apply to nondemented and normal elderly subjects, we are encouraged that the anatomy of age-related cognitive impairments can be reliably recognized and possibly put to use in therapeutic studies.

Original languageEnglish (US)
Pages (from-to)1-13
Number of pages13
JournalAnnals of the New York Academy of Sciences
Volume777
StatePublished - 1996
Externally publishedYes

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Dementia
Hippocampus
Anatomy
Alzheimer Disease
Aging of materials
Temporal Lobe
Brain
Bearings (structural)
Therapeutic Uses
Neuroimaging
Population Density
Uncertainty
Disease Progression
Magnetic resonance imaging
Imaging techniques
Data storage equipment
Population
Cognitive Dysfunction
Alzheimer's Disease
Cognitive Impairment

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

De Leon, M. J., Convit, A., George, A. E., Golomb, J., De Santi, S., Tarshish, C., ... Wisniewsk, H. (1996). In vivo structural studies of the hippocampus in normal aging and in incipient Alzheimer's disease. Annals of the New York Academy of Sciences, 777, 1-13.

In vivo structural studies of the hippocampus in normal aging and in incipient Alzheimer's disease. / De Leon, M. J.; Convit, A.; George, A. E.; Golomb, J.; De Santi, S.; Tarshish, C.; Rusinek, H.; Bobinski, Matthew; Ince, C.; Miller, D.; Wisniewsk, H.

In: Annals of the New York Academy of Sciences, Vol. 777, 1996, p. 1-13.

Research output: Contribution to journalArticle

De Leon, MJ, Convit, A, George, AE, Golomb, J, De Santi, S, Tarshish, C, Rusinek, H, Bobinski, M, Ince, C, Miller, D & Wisniewsk, H 1996, 'In vivo structural studies of the hippocampus in normal aging and in incipient Alzheimer's disease', Annals of the New York Academy of Sciences, vol. 777, pp. 1-13.
De Leon, M. J. ; Convit, A. ; George, A. E. ; Golomb, J. ; De Santi, S. ; Tarshish, C. ; Rusinek, H. ; Bobinski, Matthew ; Ince, C. ; Miller, D. ; Wisniewsk, H. / In vivo structural studies of the hippocampus in normal aging and in incipient Alzheimer's disease. In: Annals of the New York Academy of Sciences. 1996 ; Vol. 777. pp. 1-13.
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