Abstract
Numerous radiolabeled peptides have been utilized for in vivo imaging of a variety of cell surface receptors. For applications in PET using [ 18F]fluorine, peptides are radiolabeled via a prosthetic group approach. We previously developed solution-phase 18F- "click" radio-labeling and solid-phase radiolabeling using 4-[ 18F]fiuorobenzoic and 2-[18F]fluoropropionic acids. Here we compare the three different radiolabeling approaches and report the effects on PET imaging and pharmacokinetics. The prosthetic groups did have an effect; metabolites with significantly different polarities were observed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5901-5904 |
| Number of pages | 4 |
| Journal | Journal of Medicinal Chemistry |
| Volume | 51 |
| Issue number | 19 |
| DOIs | |
| State | Published - Oct 9 2008 |
ASJC Scopus subject areas
- Molecular Medicine
- Drug Discovery
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Hausner, S. H., Marik, J., Gagnon, M. K. J., & Sutcliffe, J. (2008). In vivo positron emission tomography (PET) imaging with an αvβ6 specific peptide radiolabeled using 18F-"click" chemistry: Evaluation and comparison with the corresponding 4-[18F]fluorobenzoyl- and 2-[18F] fluoropropionyl-peptides. Journal of Medicinal Chemistry, 51(19), 5901-5904. https://doi.org/10.1021/jm800608s