Abstract
Numerous radiolabeled peptides have been utilized for in vivo imaging of a variety of cell surface receptors. For applications in PET using [ 18F]fluorine, peptides are radiolabeled via a prosthetic group approach. We previously developed solution-phase 18F- "click" radio-labeling and solid-phase radiolabeling using 4-[ 18F]fiuorobenzoic and 2-[18F]fluoropropionic acids. Here we compare the three different radiolabeling approaches and report the effects on PET imaging and pharmacokinetics. The prosthetic groups did have an effect; metabolites with significantly different polarities were observed.
Original language | English (US) |
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Pages (from-to) | 5901-5904 |
Number of pages | 4 |
Journal | Journal of Medicinal Chemistry |
Volume | 51 |
Issue number | 19 |
DOIs | |
State | Published - Oct 9 2008 |
ASJC Scopus subject areas
- Molecular Medicine
- Drug Discovery