In vivo positron-emission tomography imaging of progression and transformation in a mouse model of mammary neoplasia

Craig K. Abbey, Alexander D Borowsky, Erik T. McGoldrick, Jeffrey Gregg, Jeannie E. Maglione, Robert Cardiff, Simon R Cherry

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

Imaging mouse models of human cancer promises more effective analysis of tumor progression and reduction of the number of animals needed for statistical power in preclinical therapeutic intervention trials. This study utilizes positron emission tomography imaging of 2-[18F]-fluoro-deoxy-D- glucose to monitor longitudinal development of mammary intraepithelial neoplasia outgrowths in immunocompetent FVB/NJ mice. The mammary intraepithelial neoplasia outgrowth tissues mimic the progression of breast cancer from premalignant ductal carcinoma in situ to invasive carcinoma. Progression of disease is clearly evident in the positron emission tomography images, and tracer uptake correlates with histological evaluation. Furthermore, quantitative markers of disease extracted from the images can be used to track proliferation and progression in vivo over multiple time points.

Original languageEnglish (US)
Pages (from-to)11438-11443
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume101
Issue number31
DOIs
StatePublished - Aug 3 2004

ASJC Scopus subject areas

  • Genetics
  • General

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