Abstract
Imaging mouse models of human cancer promises more effective analysis of tumor progression and reduction of the number of animals needed for statistical power in preclinical therapeutic intervention trials. This study utilizes positron emission tomography imaging of 2-[18F]-fluoro-deoxy-D- glucose to monitor longitudinal development of mammary intraepithelial neoplasia outgrowths in immunocompetent FVB/NJ mice. The mammary intraepithelial neoplasia outgrowth tissues mimic the progression of breast cancer from premalignant ductal carcinoma in situ to invasive carcinoma. Progression of disease is clearly evident in the positron emission tomography images, and tracer uptake correlates with histological evaluation. Furthermore, quantitative markers of disease extracted from the images can be used to track proliferation and progression in vivo over multiple time points.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 11438-11443 |
| Number of pages | 6 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Volume | 101 |
| Issue number | 31 |
| DOIs | |
| State | Published - Aug 3 2004 |
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ASJC Scopus subject areas
- Genetics
- General
Cite this
In vivo positron-emission tomography imaging of progression and transformation in a mouse model of mammary neoplasia. / Abbey, Craig K.; Borowsky, Alexander D; McGoldrick, Erik T.; Gregg, Jeffrey; Maglione, Jeannie E.; Cardiff, Robert; Cherry, Simon R.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, No. 31, 03.08.2004, p. 11438-11443.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In vivo positron-emission tomography imaging of progression and transformation in a mouse model of mammary neoplasia
AU - Abbey, Craig K.
AU - Borowsky, Alexander D
AU - McGoldrick, Erik T.
AU - Gregg, Jeffrey
AU - Maglione, Jeannie E.
AU - Cardiff, Robert
AU - Cherry, Simon R
PY - 2004/8/3
Y1 - 2004/8/3
N2 - Imaging mouse models of human cancer promises more effective analysis of tumor progression and reduction of the number of animals needed for statistical power in preclinical therapeutic intervention trials. This study utilizes positron emission tomography imaging of 2-[18F]-fluoro-deoxy-D- glucose to monitor longitudinal development of mammary intraepithelial neoplasia outgrowths in immunocompetent FVB/NJ mice. The mammary intraepithelial neoplasia outgrowth tissues mimic the progression of breast cancer from premalignant ductal carcinoma in situ to invasive carcinoma. Progression of disease is clearly evident in the positron emission tomography images, and tracer uptake correlates with histological evaluation. Furthermore, quantitative markers of disease extracted from the images can be used to track proliferation and progression in vivo over multiple time points.
AB - Imaging mouse models of human cancer promises more effective analysis of tumor progression and reduction of the number of animals needed for statistical power in preclinical therapeutic intervention trials. This study utilizes positron emission tomography imaging of 2-[18F]-fluoro-deoxy-D- glucose to monitor longitudinal development of mammary intraepithelial neoplasia outgrowths in immunocompetent FVB/NJ mice. The mammary intraepithelial neoplasia outgrowth tissues mimic the progression of breast cancer from premalignant ductal carcinoma in situ to invasive carcinoma. Progression of disease is clearly evident in the positron emission tomography images, and tracer uptake correlates with histological evaluation. Furthermore, quantitative markers of disease extracted from the images can be used to track proliferation and progression in vivo over multiple time points.
UR - http://www.scopus.com/inward/record.url?scp=3843130570&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=3843130570&partnerID=8YFLogxK
U2 - 10.1073/pnas.0404396101
DO - 10.1073/pnas.0404396101
M3 - Article
C2 - 15277673
AN - SCOPUS:3843130570
VL - 101
SP - 11438
EP - 11443
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 31
ER -