In vivo positron-emission tomography imaging of progression and transformation in a mouse model of mammary neoplasia

Craig K. Abbey; Alexander D. Borowsky; Erik T. McGoldrick; Jeffrey P. Gregg; Jeannie E. Maglione; Robert D. Cardiff; Simon R. Cherry

doi:10.1073/pnas.0404396101

In vivo positron-emission tomography imaging of progression and transformation in a mouse model of mammary neoplasia

Craig K. Abbey, Alexander D. Borowsky, Erik T. McGoldrick, Jeffrey P. Gregg, Jeannie E. Maglione, Robert D. Cardiff, Simon R. Cherry

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

Imaging mouse models of human cancer promises more effective analysis of tumor progression and reduction of the number of animals needed for statistical power in preclinical therapeutic intervention trials. This study utilizes positron emission tomography imaging of 2-[¹⁸F]-fluoro-deoxy-D- glucose to monitor longitudinal development of mammary intraepithelial neoplasia outgrowths in immunocompetent FVB/NJ mice. The mammary intraepithelial neoplasia outgrowth tissues mimic the progression of breast cancer from premalignant ductal carcinoma in situ to invasive carcinoma. Progression of disease is clearly evident in the positron emission tomography images, and tracer uptake correlates with histological evaluation. Furthermore, quantitative markers of disease extracted from the images can be used to track proliferation and progression in vivo over multiple time points.

Original language	English (US)
Pages (from-to)	11438-11443
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	101
Issue number	31
DOIs	https://doi.org/10.1073/pnas.0404396101
State	Published - Aug 3 2004

ASJC Scopus subject areas

Genetics
General

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Abbey, C. K., Borowsky, A. D., McGoldrick, E. T., Gregg, J. P., Maglione, J. E., Cardiff, R. D., & Cherry, S. R. (2004). In vivo positron-emission tomography imaging of progression and transformation in a mouse model of mammary neoplasia. Proceedings of the National Academy of Sciences of the United States of America, 101(31), 11438-11443. https://doi.org/10.1073/pnas.0404396101

In vivo positron-emission tomography imaging of progression and transformation in a mouse model of mammary neoplasia. / Abbey, Craig K.; Borowsky, Alexander D.; McGoldrick, Erik T.; Gregg, Jeffrey P.; Maglione, Jeannie E.; Cardiff, Robert D.; Cherry, Simon R.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, No. 31, 03.08.2004, p. 11438-11443.

Research output: Contribution to journal › Article › peer-review

Abbey, CK, Borowsky, AD, McGoldrick, ET, Gregg, JP, Maglione, JE, Cardiff, RD & Cherry, SR 2004, 'In vivo positron-emission tomography imaging of progression and transformation in a mouse model of mammary neoplasia', Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 31, pp. 11438-11443. https://doi.org/10.1073/pnas.0404396101

Abbey, Craig K. ; Borowsky, Alexander D. ; McGoldrick, Erik T. ; Gregg, Jeffrey P. ; Maglione, Jeannie E. ; Cardiff, Robert D. ; Cherry, Simon R. / In vivo positron-emission tomography imaging of progression and transformation in a mouse model of mammary neoplasia. In: Proceedings of the National Academy of Sciences of the United States of America. 2004 ; Vol. 101, No. 31. pp. 11438-11443.

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In vivo positron-emission tomography imaging of progression and transformation in a mouse model of mammary neoplasia

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