Abstract
The optical properties (absorption [μa], transport scattering [μ′s] and effective attenuation [μeff] coefficients) of normal canine prostate were measured in vivo using interstitial isotropic detectors. Measurements were made at 732 nm before, during and after motexafin lutetium (MLu)-mediated photodynamic therapy (PDT). They were derived by applying the diffusion theory to the in vivo peak fluence rates measured at several distances (3, 6, 9, 12 and 15 mm) from the central axis of a 2.5 cm cylindrical diffusing fiber (CDF). μa, and μ′s varied between 0.03-0.58 and 1.0-20 cm-1, respectively. μa, was proportional to the concentration of MLu. μ eff varied between 0.33 and 4.9 cm-1 (mean 1.3 ± 1.1 cm-1), corresponding to an optical penetration depth (δ = 1/μeff) of 0.5-3 cm (mean 1.3 ± 0.8 cm). The mean light fluence rate at 0.5 cm from the CDF was 126 ± 48 mW/cm2 (N = 22) when the total power from the fiber was 375 mW (150 mW/cm). This study showed significant inter- and intraprostatic differences in the optical properties, suggesting that a real-time dosimetry measurement and feedback system for monitoring light fluences during treatment should be advocated for future PDT studies. However, no significant changes were observed before, during and after PDT within a single treatment site.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 81-88 |
| Number of pages | 8 |
| Journal | Photochemistry and Photobiology |
| Volume | 77 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2003 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Biophysics
Cite this
In vivo Optical Properties of Normal Canine Prostate at 732 nm Using Motexafin Lutetium-mediated Photodynamic Therapy. / Zhu, Timothy C.; Hahn, Stephen M.; Kapatkin, Amy; Dimofte, Andreea; Rodriguez, Carmen E.; Vulcan, Teodor G.; Glatstein, Eli; Hsi, R. Alex.
In: Photochemistry and Photobiology, Vol. 77, No. 1, 01.2003, p. 81-88.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In vivo Optical Properties of Normal Canine Prostate at 732 nm Using Motexafin Lutetium-mediated Photodynamic Therapy
AU - Zhu, Timothy C.
AU - Hahn, Stephen M.
AU - Kapatkin, Amy
AU - Dimofte, Andreea
AU - Rodriguez, Carmen E.
AU - Vulcan, Teodor G.
AU - Glatstein, Eli
AU - Hsi, R. Alex
PY - 2003/1
Y1 - 2003/1
N2 - The optical properties (absorption [μa], transport scattering [μ′s] and effective attenuation [μeff] coefficients) of normal canine prostate were measured in vivo using interstitial isotropic detectors. Measurements were made at 732 nm before, during and after motexafin lutetium (MLu)-mediated photodynamic therapy (PDT). They were derived by applying the diffusion theory to the in vivo peak fluence rates measured at several distances (3, 6, 9, 12 and 15 mm) from the central axis of a 2.5 cm cylindrical diffusing fiber (CDF). μa, and μ′s varied between 0.03-0.58 and 1.0-20 cm-1, respectively. μa, was proportional to the concentration of MLu. μ eff varied between 0.33 and 4.9 cm-1 (mean 1.3 ± 1.1 cm-1), corresponding to an optical penetration depth (δ = 1/μeff) of 0.5-3 cm (mean 1.3 ± 0.8 cm). The mean light fluence rate at 0.5 cm from the CDF was 126 ± 48 mW/cm2 (N = 22) when the total power from the fiber was 375 mW (150 mW/cm). This study showed significant inter- and intraprostatic differences in the optical properties, suggesting that a real-time dosimetry measurement and feedback system for monitoring light fluences during treatment should be advocated for future PDT studies. However, no significant changes were observed before, during and after PDT within a single treatment site.
AB - The optical properties (absorption [μa], transport scattering [μ′s] and effective attenuation [μeff] coefficients) of normal canine prostate were measured in vivo using interstitial isotropic detectors. Measurements were made at 732 nm before, during and after motexafin lutetium (MLu)-mediated photodynamic therapy (PDT). They were derived by applying the diffusion theory to the in vivo peak fluence rates measured at several distances (3, 6, 9, 12 and 15 mm) from the central axis of a 2.5 cm cylindrical diffusing fiber (CDF). μa, and μ′s varied between 0.03-0.58 and 1.0-20 cm-1, respectively. μa, was proportional to the concentration of MLu. μ eff varied between 0.33 and 4.9 cm-1 (mean 1.3 ± 1.1 cm-1), corresponding to an optical penetration depth (δ = 1/μeff) of 0.5-3 cm (mean 1.3 ± 0.8 cm). The mean light fluence rate at 0.5 cm from the CDF was 126 ± 48 mW/cm2 (N = 22) when the total power from the fiber was 375 mW (150 mW/cm). This study showed significant inter- and intraprostatic differences in the optical properties, suggesting that a real-time dosimetry measurement and feedback system for monitoring light fluences during treatment should be advocated for future PDT studies. However, no significant changes were observed before, during and after PDT within a single treatment site.
UR - http://www.scopus.com/inward/record.url?scp=0242302542&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0242302542&partnerID=8YFLogxK
U2 - 10.1562/0031-8655(2003)077<0081:IVOPON>2.0.CO;2
DO - 10.1562/0031-8655(2003)077<0081:IVOPON>2.0.CO;2
M3 - Article
VL - 77
SP - 81
EP - 88
JO - Photochemistry and Photobiology
JF - Photochemistry and Photobiology
SN - 0031-8655
IS - 1
ER -