In vivo optical imaging and dynamic contrast methods for biomedical research

Elizabeth M C Hillman, Cyrus B. Amoozegar, Tracy Wang, Addason F H McCaslin, Matthew B. Bouchard, James Mansfield, Richard M Levenson

Research output: Contribution to journalArticlepeer-review

82 Scopus citations


This paper provides an overview of optical imaging methods commonly applied to basic research applications. Optical imaging is well suited for non-clinical use, since it can exploit an enormous range of endogenous and exogenous forms of contrast that provide information about the structure and function of tissues ranging from single cells to entire organisms. An additional benefit of optical imaging that is often under-exploited is its ability to acquire data at high speeds; a feature that enables it to not only observe static distributions of contrast, but to probe and characterize dynamic events related to physiology, disease progression and acute interventions in real time. The benefits and limitations of in vivo optical imaging for biomedical research applications are described, followed by a perspective on future applications of optical imaging for basic research centred on a recently introduced real-time imaging technique called dynamic contrastenhanced small animal molecular imaging (DyCE). This journal is

Original languageEnglish (US)
Pages (from-to)4620-4643
Number of pages24
JournalPhilosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
Issue number1955
StatePublished - Nov 28 2011
Externally publishedYes


  • Dynamic contrast
  • In vivo imaging
  • Molecular imaging
  • Optical imaging

ASJC Scopus subject areas

  • Mathematics(all)
  • Physics and Astronomy(all)
  • Engineering(all)


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