Abstract
This paper provides an overview of optical imaging methods commonly applied to basic research applications. Optical imaging is well suited for non-clinical use, since it can exploit an enormous range of endogenous and exogenous forms of contrast that provide information about the structure and function of tissues ranging from single cells to entire organisms. An additional benefit of optical imaging that is often under-exploited is its ability to acquire data at high speeds; a feature that enables it to not only observe static distributions of contrast, but to probe and characterize dynamic events related to physiology, disease progression and acute interventions in real time. The benefits and limitations of in vivo optical imaging for biomedical research applications are described, followed by a perspective on future applications of optical imaging for basic research centred on a recently introduced real-time imaging technique called dynamic contrastenhanced small animal molecular imaging (DyCE). This journal is
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4620-4643 |
| Number of pages | 24 |
| Journal | Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences |
| Volume | 369 |
| Issue number | 1955 |
| DOIs | |
| State | Published - Nov 28 2011 |
| Externally published | Yes |
Fingerprint
Keywords
- Dynamic contrast
- In vivo imaging
- Molecular imaging
- Optical imaging
ASJC Scopus subject areas
- Mathematics(all)
- Physics and Astronomy(all)
- Engineering(all)
Cite this
In vivo optical imaging and dynamic contrast methods for biomedical research. / Hillman, Elizabeth M C; Amoozegar, Cyrus B.; Wang, Tracy; McCaslin, Addason F H; Bouchard, Matthew B.; Mansfield, James; Levenson, Richard M.
In: Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, Vol. 369, No. 1955, 28.11.2011, p. 4620-4643.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In vivo optical imaging and dynamic contrast methods for biomedical research
AU - Hillman, Elizabeth M C
AU - Amoozegar, Cyrus B.
AU - Wang, Tracy
AU - McCaslin, Addason F H
AU - Bouchard, Matthew B.
AU - Mansfield, James
AU - Levenson, Richard M
PY - 2011/11/28
Y1 - 2011/11/28
N2 - This paper provides an overview of optical imaging methods commonly applied to basic research applications. Optical imaging is well suited for non-clinical use, since it can exploit an enormous range of endogenous and exogenous forms of contrast that provide information about the structure and function of tissues ranging from single cells to entire organisms. An additional benefit of optical imaging that is often under-exploited is its ability to acquire data at high speeds; a feature that enables it to not only observe static distributions of contrast, but to probe and characterize dynamic events related to physiology, disease progression and acute interventions in real time. The benefits and limitations of in vivo optical imaging for biomedical research applications are described, followed by a perspective on future applications of optical imaging for basic research centred on a recently introduced real-time imaging technique called dynamic contrastenhanced small animal molecular imaging (DyCE). This journal is
AB - This paper provides an overview of optical imaging methods commonly applied to basic research applications. Optical imaging is well suited for non-clinical use, since it can exploit an enormous range of endogenous and exogenous forms of contrast that provide information about the structure and function of tissues ranging from single cells to entire organisms. An additional benefit of optical imaging that is often under-exploited is its ability to acquire data at high speeds; a feature that enables it to not only observe static distributions of contrast, but to probe and characterize dynamic events related to physiology, disease progression and acute interventions in real time. The benefits and limitations of in vivo optical imaging for biomedical research applications are described, followed by a perspective on future applications of optical imaging for basic research centred on a recently introduced real-time imaging technique called dynamic contrastenhanced small animal molecular imaging (DyCE). This journal is
KW - Dynamic contrast
KW - In vivo imaging
KW - Molecular imaging
KW - Optical imaging
UR - http://www.scopus.com/inward/record.url?scp=82055208752&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=82055208752&partnerID=8YFLogxK
U2 - 10.1098/rsta.2011.0264
DO - 10.1098/rsta.2011.0264
M3 - Article
C2 - 22006910
AN - SCOPUS:82055208752
VL - 369
SP - 4620
EP - 4643
JO - Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
JF - Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
SN - 0962-8428
IS - 1955
ER -