In-vivo NIR autofluorescence of rat mammay tumors discriminates pathological malignancy

Laure S. Fournier, Vincenzo Lucidi, Werner Rosenau, Stavros G. Demos, Robert C. Brasch

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Benign and malignant mammary tumors were induced in rats using a potent carcinogen, N-ethyl-N-nitrosurea (ENU). Induced tumors were examined under near-infrared (NIR) fluorescence imaging (excitation wavelength 670-730 nm, detection wavelength 750-800 nm) to search for a difference in the photophysical properties of the tumors reflecting their pathologic status. Three benign and eight malignant tumors were examined optically and pathologically. THe non-enhanced optical images showed a significantly lower (P<0.05) spontaneous fluorescent signal in the benign tumors than in their malignant counterparts. The precise chemical origin for the observed differences in tumor autofluorescence remains undetermined. It can be hypothesized that the reported high concentration of porphyrins, NIR-fluorescing compounds, in the malignant lesions, could account for the observed increased autofluorescence.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsG.A. Wagnieres
Pages33-39
Number of pages7
Volume5141
StatePublished - 2003
Externally publishedYes
EventDiagnostic Optical Spectroscopy in Biomedicine II - Munich, Germany
Duration: Jun 24 2003Jun 25 2003

Other

OtherDiagnostic Optical Spectroscopy in Biomedicine II
CountryGermany
CityMunich
Period6/24/036/25/03

Fingerprint

rats
Rats
Tumors
tumors
Infrared radiation
carcinogens
Wavelength
Carcinogens
Porphyrins
porphyrins
wavelengths
lesions
Fluorescence
Imaging techniques
fluorescence
excitation

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Fournier, L. S., Lucidi, V., Rosenau, W., Demos, S. G., & Brasch, R. C. (2003). In-vivo NIR autofluorescence of rat mammay tumors discriminates pathological malignancy. In G. A. Wagnieres (Ed.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 5141, pp. 33-39)

In-vivo NIR autofluorescence of rat mammay tumors discriminates pathological malignancy. / Fournier, Laure S.; Lucidi, Vincenzo; Rosenau, Werner; Demos, Stavros G.; Brasch, Robert C.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / G.A. Wagnieres. Vol. 5141 2003. p. 33-39.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Fournier, LS, Lucidi, V, Rosenau, W, Demos, SG & Brasch, RC 2003, In-vivo NIR autofluorescence of rat mammay tumors discriminates pathological malignancy. in GA Wagnieres (ed.), Proceedings of SPIE - The International Society for Optical Engineering. vol. 5141, pp. 33-39, Diagnostic Optical Spectroscopy in Biomedicine II, Munich, Germany, 6/24/03.
Fournier LS, Lucidi V, Rosenau W, Demos SG, Brasch RC. In-vivo NIR autofluorescence of rat mammay tumors discriminates pathological malignancy. In Wagnieres GA, editor, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 5141. 2003. p. 33-39
Fournier, Laure S. ; Lucidi, Vincenzo ; Rosenau, Werner ; Demos, Stavros G. ; Brasch, Robert C. / In-vivo NIR autofluorescence of rat mammay tumors discriminates pathological malignancy. Proceedings of SPIE - The International Society for Optical Engineering. editor / G.A. Wagnieres. Vol. 5141 2003. pp. 33-39
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