In-vivo NIR autofluorescence of rat mammay tumors discriminates pathological malignancy

Laure S. Fournier; Vincenzo Lucidi; Werner Rosenau; Stavros G. Demos; Robert C. Brasch

In-vivo NIR autofluorescence of rat mammay tumors discriminates pathological malignancy

Laure S. Fournier, Vincenzo Lucidi, Werner Rosenau, Stavros G. Demos, Robert C. Brasch

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Benign and malignant mammary tumors were induced in rats using a potent carcinogen, N-ethyl-N-nitrosurea (ENU). Induced tumors were examined under near-infrared (NIR) fluorescence imaging (excitation wavelength 670-730 nm, detection wavelength 750-800 nm) to search for a difference in the photophysical properties of the tumors reflecting their pathologic status. Three benign and eight malignant tumors were examined optically and pathologically. THe non-enhanced optical images showed a significantly lower (P<0.05) spontaneous fluorescent signal in the benign tumors than in their malignant counterparts. The precise chemical origin for the observed differences in tumor autofluorescence remains undetermined. It can be hypothesized that the reported high concentration of porphyrins, NIR-fluorescing compounds, in the malignant lesions, could account for the observed increased autofluorescence.

Original language	English (US)
Title of host publication	Proceedings of SPIE - The International Society for Optical Engineering
Editors	G.A. Wagnieres
Pages	33-39
Number of pages	7
Volume	5141
State	Published - 2003
Externally published	Yes
Event	Diagnostic Optical Spectroscopy in Biomedicine II - Munich, Germany Duration: Jun 24 2003 → Jun 25 2003

Other

Other	Diagnostic Optical Spectroscopy in Biomedicine II
Country	Germany
City	Munich
Period	6/24/03 → 6/25/03

ASJC Scopus subject areas

Electrical and Electronic Engineering
Condensed Matter Physics

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In-vivo NIR autofluorescence of rat mammay tumors discriminates pathological malignancy. / Fournier, Laure S.; Lucidi, Vincenzo; Rosenau, Werner; Demos, Stavros G.; Brasch, Robert C.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / G.A. Wagnieres. Vol. 5141 2003. p. 33-39.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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abstract = "Benign and malignant mammary tumors were induced in rats using a potent carcinogen, N-ethyl-N-nitrosurea (ENU). Induced tumors were examined under near-infrared (NIR) fluorescence imaging (excitation wavelength 670-730 nm, detection wavelength 750-800 nm) to search for a difference in the photophysical properties of the tumors reflecting their pathologic status. Three benign and eight malignant tumors were examined optically and pathologically. THe non-enhanced optical images showed a significantly lower (P<0.05) spontaneous fluorescent signal in the benign tumors than in their malignant counterparts. The precise chemical origin for the observed differences in tumor autofluorescence remains undetermined. It can be hypothesized that the reported high concentration of porphyrins, NIR-fluorescing compounds, in the malignant lesions, could account for the observed increased autofluorescence.",

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AB - Benign and malignant mammary tumors were induced in rats using a potent carcinogen, N-ethyl-N-nitrosurea (ENU). Induced tumors were examined under near-infrared (NIR) fluorescence imaging (excitation wavelength 670-730 nm, detection wavelength 750-800 nm) to search for a difference in the photophysical properties of the tumors reflecting their pathologic status. Three benign and eight malignant tumors were examined optically and pathologically. THe non-enhanced optical images showed a significantly lower (P<0.05) spontaneous fluorescent signal in the benign tumors than in their malignant counterparts. The precise chemical origin for the observed differences in tumor autofluorescence remains undetermined. It can be hypothesized that the reported high concentration of porphyrins, NIR-fluorescing compounds, in the malignant lesions, could account for the observed increased autofluorescence.

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