Abstract
Benign and malignant mammary tumors were induced in rats using a potent carcinogen, N-ethyl-N-nitrosurea (ENU). Induced tumors were examined under near-infrared (NIR) fluorescence imaging (excitation wavelength 670-730 nm, detection wavelength 750-800 nm) to search for a difference in the photophysical properties of the tumors reflecting their pathologic status. Three benign and eight malignant tumors were examined optically and pathologically. THe non-enhanced optical images showed a significantly lower (P<0.05) spontaneous fluorescent signal in the benign tumors than in their malignant counterparts. The precise chemical origin for the observed differences in tumor autofluorescence remains undetermined. It can be hypothesized that the reported high concentration of porphyrins, NIR-fluorescing compounds, in the malignant lesions, could account for the observed increased autofluorescence.
| Original language | English (US) |
|---|---|
| Title of host publication | Proceedings of SPIE - The International Society for Optical Engineering |
| Editors | G.A. Wagnieres |
| Pages | 33-39 |
| Number of pages | 7 |
| Volume | 5141 |
| State | Published - 2003 |
| Externally published | Yes |
| Event | Diagnostic Optical Spectroscopy in Biomedicine II - Munich, Germany Duration: Jun 24 2003 → Jun 25 2003 |
Other
| Other | Diagnostic Optical Spectroscopy in Biomedicine II |
|---|---|
| Country | Germany |
| City | Munich |
| Period | 6/24/03 → 6/25/03 |
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ASJC Scopus subject areas
- Electrical and Electronic Engineering
- Condensed Matter Physics
Cite this
In-vivo NIR autofluorescence of rat mammay tumors discriminates pathological malignancy. / Fournier, Laure S.; Lucidi, Vincenzo; Rosenau, Werner; Demos, Stavros G.; Brasch, Robert C.
Proceedings of SPIE - The International Society for Optical Engineering. ed. / G.A. Wagnieres. Vol. 5141 2003. p. 33-39.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - In-vivo NIR autofluorescence of rat mammay tumors discriminates pathological malignancy
AU - Fournier, Laure S.
AU - Lucidi, Vincenzo
AU - Rosenau, Werner
AU - Demos, Stavros G.
AU - Brasch, Robert C.
PY - 2003
Y1 - 2003
N2 - Benign and malignant mammary tumors were induced in rats using a potent carcinogen, N-ethyl-N-nitrosurea (ENU). Induced tumors were examined under near-infrared (NIR) fluorescence imaging (excitation wavelength 670-730 nm, detection wavelength 750-800 nm) to search for a difference in the photophysical properties of the tumors reflecting their pathologic status. Three benign and eight malignant tumors were examined optically and pathologically. THe non-enhanced optical images showed a significantly lower (P<0.05) spontaneous fluorescent signal in the benign tumors than in their malignant counterparts. The precise chemical origin for the observed differences in tumor autofluorescence remains undetermined. It can be hypothesized that the reported high concentration of porphyrins, NIR-fluorescing compounds, in the malignant lesions, could account for the observed increased autofluorescence.
AB - Benign and malignant mammary tumors were induced in rats using a potent carcinogen, N-ethyl-N-nitrosurea (ENU). Induced tumors were examined under near-infrared (NIR) fluorescence imaging (excitation wavelength 670-730 nm, detection wavelength 750-800 nm) to search for a difference in the photophysical properties of the tumors reflecting their pathologic status. Three benign and eight malignant tumors were examined optically and pathologically. THe non-enhanced optical images showed a significantly lower (P<0.05) spontaneous fluorescent signal in the benign tumors than in their malignant counterparts. The precise chemical origin for the observed differences in tumor autofluorescence remains undetermined. It can be hypothesized that the reported high concentration of porphyrins, NIR-fluorescing compounds, in the malignant lesions, could account for the observed increased autofluorescence.
UR - http://www.scopus.com/inward/record.url?scp=1342326465&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1342326465&partnerID=8YFLogxK
M3 - Conference contribution
VL - 5141
SP - 33
EP - 39
BT - Proceedings of SPIE - The International Society for Optical Engineering
A2 - Wagnieres, G.A.
ER -