In-vivo NIR autofluorescence of rat mammay tumors discriminates pathological malignancy

Laure S. Fournier, Vincenzo Lucidi, Werner Rosenau, Stavros G. Demos, Robert C. Brasch

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Benign and malignant mammary tumors were induced in rats using a potent carcinogen, N-ethyl-N-nitrosurea (ENU). Induced tumors were examined under near-infrared (NIR) fluorescence imaging (excitation wavelength 670-730 nm, detection wavelength 750-800 nm) to search for a difference in the photophysical properties of the tumors reflecting their pathologic status. Three benign and eight malignant tumors were examined optically and pathologically. THe non-enhanced optical images showed a significantly lower (P<0.05) spontaneous fluorescent signal in the benign tumors than in their malignant counterparts. The precise chemical origin for the observed differences in tumor autofluorescence remains undetermined. It can be hypothesized that the reported high concentration of porphyrins, NIR-fluorescing compounds, in the malignant lesions, could account for the observed increased autofluorescence.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsG.A. Wagnieres
Number of pages7
StatePublished - 2003
Externally publishedYes
EventDiagnostic Optical Spectroscopy in Biomedicine II - Munich, Germany
Duration: Jun 24 2003Jun 25 2003


OtherDiagnostic Optical Spectroscopy in Biomedicine II

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics


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