In-vivo NIR autofluorescence imaging of rat mammary tumors

Laure S. Fournier, Vincenzo Lucidi, Kirill Berejnoi, Theodore Miller, Stavros G. Demos, Robert C. Brasch

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


We investigate in vivo detection of mammary tumors in a rat model using autofluorescence imaging in the red and far-red spectral regions. The objective was to explore this method for non-invasive detection of malignant tumors and correlation between autofluorescence properties of tumors and their pathologic status. Eighteen tumor-bearing rats, bearing eight benign and seventeen malignant tumors were imaged. Autofluorescence images were acquired using spectral windows centered at 700-nm, 750-nm and 800-nm under laser excitation at 632.8-nm and 670-nm. Intensity in the autofluorescence images of malignant tumors under 670-nm excitation was higher than that of the adjacent normal tissue, whereas intensity of benign tumors was lower compared to normal tissue.

Original languageEnglish (US)
Pages (from-to)6713-6723
Number of pages11
JournalOptics Express
Issue number15
StatePublished - 2006
Externally publishedYes

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics


Dive into the research topics of 'In-vivo NIR autofluorescence imaging of rat mammary tumors'. Together they form a unique fingerprint.

Cite this