In-vivo NIR autofluorescence imaging of rat mammary tumors

Laure S. Fournier, Vincenzo Lucidi, Kirill Berejnoi, Theodore Miller, Stavros G. Demos, Robert C. Brasch

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We investigate in vivo detection of mammary tumors in a rat model using autofluorescence imaging in the red and far-red spectral regions. The objective was to explore this method for non-invasive detection of malignant tumors and correlation between autofluorescence properties of tumors and their pathologic status. Eighteen tumor-bearing rats, bearing eight benign and seventeen malignant tumors were imaged. Autofluorescence images were acquired using spectral windows centered at 700-nm, 750-nm and 800-nm under laser excitation at 632.8-nm and 670-nm. Intensity in the autofluorescence images of malignant tumors under 670-nm excitation was higher than that of the adjacent normal tissue, whereas intensity of benign tumors was lower compared to normal tissue.

Original languageEnglish (US)
Pages (from-to)6713-6723
Number of pages11
JournalOptics Express
Volume14
Issue number15
DOIs
StatePublished - 2006
Externally publishedYes

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rats
tumors
excitation
lasers

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

Cite this

Fournier, L. S., Lucidi, V., Berejnoi, K., Miller, T., Demos, S. G., & Brasch, R. C. (2006). In-vivo NIR autofluorescence imaging of rat mammary tumors. Optics Express, 14(15), 6713-6723. https://doi.org/10.1364/OE.14.006713

In-vivo NIR autofluorescence imaging of rat mammary tumors. / Fournier, Laure S.; Lucidi, Vincenzo; Berejnoi, Kirill; Miller, Theodore; Demos, Stavros G.; Brasch, Robert C.

In: Optics Express, Vol. 14, No. 15, 2006, p. 6713-6723.

Research output: Contribution to journalArticle

Fournier, LS, Lucidi, V, Berejnoi, K, Miller, T, Demos, SG & Brasch, RC 2006, 'In-vivo NIR autofluorescence imaging of rat mammary tumors', Optics Express, vol. 14, no. 15, pp. 6713-6723. https://doi.org/10.1364/OE.14.006713
Fournier LS, Lucidi V, Berejnoi K, Miller T, Demos SG, Brasch RC. In-vivo NIR autofluorescence imaging of rat mammary tumors. Optics Express. 2006;14(15):6713-6723. https://doi.org/10.1364/OE.14.006713
Fournier, Laure S. ; Lucidi, Vincenzo ; Berejnoi, Kirill ; Miller, Theodore ; Demos, Stavros G. ; Brasch, Robert C. / In-vivo NIR autofluorescence imaging of rat mammary tumors. In: Optics Express. 2006 ; Vol. 14, No. 15. pp. 6713-6723.
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