In-vivo NIR autofluorescence imaging of rat mammary tumors

Laure S. Fournier, Vincenzo Lucidi, Kirill Berejnoi, Theodore Miller, Stavros G. Demos, Robert C. Brasch

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

We investigate in vivo detection of mammary tumors in a rat model using autofluorescence imaging in the red and far-red spectral regions. The objective was to explore this method for non-invasive detection of malignant tumors and correlation between autofluorescence properties of tumors and their pathologic status. Eighteen tumor-bearing rats, bearing eight benign and seventeen malignant tumors were imaged. Autofluorescence images were acquired using spectral windows centered at 700-nm, 750-nm and 800-nm under laser excitation at 632.8-nm and 670-nm. Intensity in the autofluorescence images of malignant tumors under 670-nm excitation was higher than that of the adjacent normal tissue, whereas intensity of benign tumors was lower compared to normal tissue.

Original languageEnglish (US)
Pages (from-to)6713-6723
Number of pages11
JournalOptics Express
Volume14
Issue number15
DOIs
StatePublished - 2006
Externally publishedYes

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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    Fournier, L. S., Lucidi, V., Berejnoi, K., Miller, T., Demos, S. G., & Brasch, R. C. (2006). In-vivo NIR autofluorescence imaging of rat mammary tumors. Optics Express, 14(15), 6713-6723. https://doi.org/10.1364/OE.14.006713