Abstract
We investigate in vivo detection of mammary tumors in a rat model using autofluorescence imaging in the red and far-red spectral regions. The objective was to explore this method for non-invasive detection of malignant tumors and correlation between autofluorescence properties of tumors and their pathologic status. Eighteen tumor-bearing rats, bearing eight benign and seventeen malignant tumors were imaged. Autofluorescence images were acquired using spectral windows centered at 700-nm, 750-nm and 800-nm under laser excitation at 632.8-nm and 670-nm. Intensity in the autofluorescence images of malignant tumors under 670-nm excitation was higher than that of the adjacent normal tissue, whereas intensity of benign tumors was lower compared to normal tissue.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 6713-6723 |
| Number of pages | 11 |
| Journal | Optics Express |
| Volume | 14 |
| Issue number | 15 |
| DOIs | |
| State | Published - 2006 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics
Cite this
In-vivo NIR autofluorescence imaging of rat mammary tumors. / Fournier, Laure S.; Lucidi, Vincenzo; Berejnoi, Kirill; Miller, Theodore; Demos, Stavros G.; Brasch, Robert C.
In: Optics Express, Vol. 14, No. 15, 2006, p. 6713-6723.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In-vivo NIR autofluorescence imaging of rat mammary tumors
AU - Fournier, Laure S.
AU - Lucidi, Vincenzo
AU - Berejnoi, Kirill
AU - Miller, Theodore
AU - Demos, Stavros G.
AU - Brasch, Robert C.
PY - 2006
Y1 - 2006
N2 - We investigate in vivo detection of mammary tumors in a rat model using autofluorescence imaging in the red and far-red spectral regions. The objective was to explore this method for non-invasive detection of malignant tumors and correlation between autofluorescence properties of tumors and their pathologic status. Eighteen tumor-bearing rats, bearing eight benign and seventeen malignant tumors were imaged. Autofluorescence images were acquired using spectral windows centered at 700-nm, 750-nm and 800-nm under laser excitation at 632.8-nm and 670-nm. Intensity in the autofluorescence images of malignant tumors under 670-nm excitation was higher than that of the adjacent normal tissue, whereas intensity of benign tumors was lower compared to normal tissue.
AB - We investigate in vivo detection of mammary tumors in a rat model using autofluorescence imaging in the red and far-red spectral regions. The objective was to explore this method for non-invasive detection of malignant tumors and correlation between autofluorescence properties of tumors and their pathologic status. Eighteen tumor-bearing rats, bearing eight benign and seventeen malignant tumors were imaged. Autofluorescence images were acquired using spectral windows centered at 700-nm, 750-nm and 800-nm under laser excitation at 632.8-nm and 670-nm. Intensity in the autofluorescence images of malignant tumors under 670-nm excitation was higher than that of the adjacent normal tissue, whereas intensity of benign tumors was lower compared to normal tissue.
UR - http://www.scopus.com/inward/record.url?scp=33746351726&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33746351726&partnerID=8YFLogxK
U2 - 10.1364/OE.14.006713
DO - 10.1364/OE.14.006713
M3 - Article
C2 - 19516853
AN - SCOPUS:33746351726
VL - 14
SP - 6713
EP - 6723
JO - Optics Express
JF - Optics Express
SN - 1094-4087
IS - 15
ER -