In Vivo MRI of Functionalized Iron Oxide Nanoparticles for Brain Inflammation

Tang Tang, Anthony Valenzuela, Fanny Petit, Sarah Chow, Kevin Leung, Fredric A Gorin, Angelique Y. Louie, Marc Dhenain

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Microglia are intrinsic components of the brain immune system and are activated in many central nervous system disorders. The ability to noninvasively image these cells would provide valuable information for both research and clinical applications. Today, most imaging probes for activated microglia are mainly designed for positron emission tomography (PET) and target translocator proteins that also reside on other cerebral cells. The PET images obtained are not specific for microglia-driven inflammation. Here, we describe a potential PET/MRI multimodal imaging probe that selectively targets the scavenger receptor class A (SR-A) expressed on activated microglia. These sulfated dextran-coated iron oxide (SDIO) nanoparticles are avidly taken up by microglia and appear to be nontoxic when administered intravenously in a mouse model. Intravenous administration of this SDIO demonstrated visualization by T2∗-weighted MRI of microglia activated by intracerebral administration of tumor necrosis factor alpha (TNF-α). The contrast was significantly enhanced by SDIO, whereas there was little to no contrast change in animals treated with nontargeted nanoparticles or untreated controls. Thus, SR-A targeting represents a promising strategy to image activated microglia in the brain.

Original languageEnglish (US)
Article number3476476
JournalContrast Media and Molecular Imaging
Volume2018
DOIs
StatePublished - Jan 1 2018

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Microglia
Encephalitis
Nanoparticles
Class A Scavenger Receptors
Dextrans
Positron-Emission Tomography
Multimodal Imaging
Central Nervous System Diseases
Brain
ferric oxide
Intravenous Administration
Immune System
Tumor Necrosis Factor-alpha
Inflammation
Research
Proteins

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

In Vivo MRI of Functionalized Iron Oxide Nanoparticles for Brain Inflammation. / Tang, Tang; Valenzuela, Anthony; Petit, Fanny; Chow, Sarah; Leung, Kevin; Gorin, Fredric A; Louie, Angelique Y.; Dhenain, Marc.

In: Contrast Media and Molecular Imaging, Vol. 2018, 3476476, 01.01.2018.

Research output: Contribution to journalArticle

Tang, T, Valenzuela, A, Petit, F, Chow, S, Leung, K, Gorin, FA, Louie, AY & Dhenain, M 2018, 'In Vivo MRI of Functionalized Iron Oxide Nanoparticles for Brain Inflammation', Contrast Media and Molecular Imaging, vol. 2018, 3476476. https://doi.org/10.1155/2018/3476476
Tang, Tang ; Valenzuela, Anthony ; Petit, Fanny ; Chow, Sarah ; Leung, Kevin ; Gorin, Fredric A ; Louie, Angelique Y. ; Dhenain, Marc. / In Vivo MRI of Functionalized Iron Oxide Nanoparticles for Brain Inflammation. In: Contrast Media and Molecular Imaging. 2018 ; Vol. 2018.
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