In vivo imaging of human photoreceptor mosaic with wavefront sensorless adaptive optics optical coherence tomography

Kevin S K Wong, Yifan Jian, Michelle Cua, Stefano Bonora, Robert Zawadzki, Marinko V. Sarunic

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Wavefront sensorless adaptive optics optical coherence tomography (WSAO-OCT) is a novel imaging technique for in vivo highresolution depth-resolved imaging that mitigates some of the challenges encountered with the use of sensor-based adaptive optics designs. This technique replaces the Hartmann Shack wavefront sensor used to measure aberrations with a depth-resolved image-driven optimization algorithm, with the metric based on the OCT volumes acquired in real-time. The custom-built ultrahigh-speed GPU processing platform and fast modal optimization algorithm presented in this paper was essential in enabling real-time, in vivo imaging of human retinas with wavefront sensorless AO correction. WSAO-OCT is especially advantageous for developing a clinical high-resolution retinal imaging system as it enables the use of a compact, low-cost and robust lens-based adaptive optics design. In this report, we describe our WSAO-OCT system for imaging the human photoreceptor mosaic in vivo. We validated our system performance by imaging the retina at several eccentricities, and demonstrated the improvement in photoreceptor visibility with WSAO compensation.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalBiomedical Optics Express
Volume6
Issue number2
DOIs
StatePublished - Jan 1 2015

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photoreceptors
Optical Coherence Tomography
adaptive optics
tomography
Retina
retina
Compensation and Redress
Lenses
optimization
sensors
Costs and Cost Analysis
eccentricity
visibility
imaging techniques
aberration
platforms
lenses
high resolution

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Biotechnology

Cite this

In vivo imaging of human photoreceptor mosaic with wavefront sensorless adaptive optics optical coherence tomography. / Wong, Kevin S K; Jian, Yifan; Cua, Michelle; Bonora, Stefano; Zawadzki, Robert; Sarunic, Marinko V.

In: Biomedical Optics Express, Vol. 6, No. 2, 01.01.2015, p. 1-11.

Research output: Contribution to journalArticle

Wong, Kevin S K ; Jian, Yifan ; Cua, Michelle ; Bonora, Stefano ; Zawadzki, Robert ; Sarunic, Marinko V. / In vivo imaging of human photoreceptor mosaic with wavefront sensorless adaptive optics optical coherence tomography. In: Biomedical Optics Express. 2015 ; Vol. 6, No. 2. pp. 1-11.
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