In vivo dose measurement using tlds and MOSFET dosimeters for cardiac radiosurgery

Edward A. Gardner, Thilaka S. Sumanaweera, Oliver Blanck, Alyson K. Iwamura, James P. Steel, Sonja Dieterich, Patrick Maguire

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

In vivo measurements were made of the dose delivered to animal models in an effort to develop a method for treating cardiac arrhythmia using radiation. This treatment would replace RF energy (currently used to create cardiac scar) with ionizing radiation. In the current study, the pulmonary vein ostia of animal models were irradiated with 6 MV X-rays in order to produce a scar that would block aberrant signals characteristic of atrial fibrillation. The CyberKnife radiosurgery system was used to deliver planned treatments of 20-35 Gy in a single fraction to four animals. The Synchrony system was used to track respiratory motion of the heart, while the contractile motion of the heart was untracked. The dose was measured on the epicardial surface near the right pulmonary vein and on the esophagus using surgically implanted TLD dosimeters, or in the coronary sinus using a MOSFET dosimeter placed using a catheter. The doses measured on the epicardium with TLDs averaged 5% less than predicted for those locations, while doses measured in the coronary sinus with the MOSFET sensor nearest the target averaged 6% less than the predicted dose. The measurements on the esophagus averaged 25% less than predicted. These results provide an indication of the accuracy with which the treatment planning methods accounted for the motion of the target, with its respiratory and cardiac components. This is the first report on the accuracy of CyberKnife dose delivery to cardiac targets.

Original languageEnglish (US)
Pages (from-to)190-203
Number of pages14
JournalJournal of Applied Clinical Medical Physics
Volume13
Issue number3
StatePublished - 2012
Externally publishedYes

Fingerprint

Radiosurgery
Dosimeters
Dosimetry
dosimeters
Animals
field effect transistors
Coronary Sinus
Pulmonary Veins
dosage
Esophagus
Cicatrix
Animal Models
sinuses
esophagus
scars
animal models
Catheters
Pericardium
Ionizing radiation
Ionizing Radiation

Keywords

  • Ablation
  • Arrhythmia
  • Cyberknife
  • In vivo dosimetry
  • Radiosurgery

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiation
  • Instrumentation

Cite this

Gardner, E. A., Sumanaweera, T. S., Blanck, O., Iwamura, A. K., Steel, J. P., Dieterich, S., & Maguire, P. (2012). In vivo dose measurement using tlds and MOSFET dosimeters for cardiac radiosurgery. Journal of Applied Clinical Medical Physics, 13(3), 190-203.

In vivo dose measurement using tlds and MOSFET dosimeters for cardiac radiosurgery. / Gardner, Edward A.; Sumanaweera, Thilaka S.; Blanck, Oliver; Iwamura, Alyson K.; Steel, James P.; Dieterich, Sonja; Maguire, Patrick.

In: Journal of Applied Clinical Medical Physics, Vol. 13, No. 3, 2012, p. 190-203.

Research output: Contribution to journalArticle

Gardner, EA, Sumanaweera, TS, Blanck, O, Iwamura, AK, Steel, JP, Dieterich, S & Maguire, P 2012, 'In vivo dose measurement using tlds and MOSFET dosimeters for cardiac radiosurgery', Journal of Applied Clinical Medical Physics, vol. 13, no. 3, pp. 190-203.
Gardner, Edward A. ; Sumanaweera, Thilaka S. ; Blanck, Oliver ; Iwamura, Alyson K. ; Steel, James P. ; Dieterich, Sonja ; Maguire, Patrick. / In vivo dose measurement using tlds and MOSFET dosimeters for cardiac radiosurgery. In: Journal of Applied Clinical Medical Physics. 2012 ; Vol. 13, No. 3. pp. 190-203.
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