In vivo corneal high-speed, ultra-high-resolution optical coherence tomography

Viki Christopoulos, Larry Kagemann, Gadi Wollstein, Hiroshi Ishikawa, Michelle L. Gabriele, Maciej Wojtkowski, Vivek Srinivasan, James G. Fujimoto, Jay S. Duker, Deepinder K. Dhaliwal, Joel S. Schuman

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Objective: To introduce new corneal high-speed, ultra-high-resolution optical coherence tomography (hsUHR-OCT) technology that improves the evaluation of complicated and uncomplicated cataract, corneal, and refractive surgical procedures. Design: This case series included a control subject and 9 eyes of 8 patients who had undergone phacoemulsification, Descemet membrane stripping endokeratoplasty, corneal implantation for keratoconus, and complicated and uncomplicated laser in situ keratomileusis. These eyes underwent imaging using a prototype ophthalmic hsUHR-OCT system. All the scans were compared with conventional slitlamp biomicroscopy. Results: Cross-sectional hsUHR-OCT imaging allowed in vivo differentiation of corneal layers and existing pathologic abnormalities at ultrahigh axial image resolution. These images illustrate the various incisional and refractive interfaces created with corneal procedures. Conclusions: The magnified view of the cornea using hsUHR-OCT is helpful in conceptualizing and understanding basic and complicated clinical pathologic features; hsUHR-OCT has the potential to become a powerful, noninvasive clinical corneal imaging modality that can enhance surgical management. Trial Registration: clinicaltrials.gov Identifier: NCT00343473.

Original languageEnglish (US)
Pages (from-to)1027-1035
Number of pages9
JournalArchives of Ophthalmology
Volume125
Issue number8
DOIs
StatePublished - Aug 1 2007
Externally publishedYes

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Optical Coherence Tomography
Descemet Membrane
Refractive Surgical Procedures
Keratoconus
Laser In Situ Keratomileusis
Phacoemulsification
Cornea
Cataract
Technology

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Christopoulos, V., Kagemann, L., Wollstein, G., Ishikawa, H., Gabriele, M. L., Wojtkowski, M., ... Schuman, J. S. (2007). In vivo corneal high-speed, ultra-high-resolution optical coherence tomography. Archives of Ophthalmology, 125(8), 1027-1035. https://doi.org/10.1001/archopht.125.8.1027

In vivo corneal high-speed, ultra-high-resolution optical coherence tomography. / Christopoulos, Viki; Kagemann, Larry; Wollstein, Gadi; Ishikawa, Hiroshi; Gabriele, Michelle L.; Wojtkowski, Maciej; Srinivasan, Vivek; Fujimoto, James G.; Duker, Jay S.; Dhaliwal, Deepinder K.; Schuman, Joel S.

In: Archives of Ophthalmology, Vol. 125, No. 8, 01.08.2007, p. 1027-1035.

Research output: Contribution to journalArticle

Christopoulos, V, Kagemann, L, Wollstein, G, Ishikawa, H, Gabriele, ML, Wojtkowski, M, Srinivasan, V, Fujimoto, JG, Duker, JS, Dhaliwal, DK & Schuman, JS 2007, 'In vivo corneal high-speed, ultra-high-resolution optical coherence tomography', Archives of Ophthalmology, vol. 125, no. 8, pp. 1027-1035. https://doi.org/10.1001/archopht.125.8.1027
Christopoulos V, Kagemann L, Wollstein G, Ishikawa H, Gabriele ML, Wojtkowski M et al. In vivo corneal high-speed, ultra-high-resolution optical coherence tomography. Archives of Ophthalmology. 2007 Aug 1;125(8):1027-1035. https://doi.org/10.1001/archopht.125.8.1027
Christopoulos, Viki ; Kagemann, Larry ; Wollstein, Gadi ; Ishikawa, Hiroshi ; Gabriele, Michelle L. ; Wojtkowski, Maciej ; Srinivasan, Vivek ; Fujimoto, James G. ; Duker, Jay S. ; Dhaliwal, Deepinder K. ; Schuman, Joel S. / In vivo corneal high-speed, ultra-high-resolution optical coherence tomography. In: Archives of Ophthalmology. 2007 ; Vol. 125, No. 8. pp. 1027-1035.
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