In-vivo argon laser vascular welding using thermal feedback: Open- and closed-loop patency and collagen crosslinking

Ward Small IV; Peter M. Celliers; George E. Kopchok; Karen M. Reiser; Nicholas J. Heredia; Duncan J. Maitland; David C. Eder; Richard A. London; Mauricio Heilbron; Farabi Hussain; Rodney A. White; Luiz B. Da Silva; Dennis L Matthews

doi:10.1117/12.275050

In-vivo argon laser vascular welding using thermal feedback: Open- and closed-loop patency and collagen crosslinking

Ward Small IV, Peter M. Celliers, George E. Kopchok, Karen M. Reiser, Nicholas J. Heredia, Duncan J. Maitland, David C. Eder, Richard A. London, Mauricio Heilbron, Farabi Hussain, Rodney A. White, Luiz B. Da Silva, Dennis L Matthews

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Scopus citations

Abstract

An in vivo study of vascular welding with a fiber-delivered argon laser was conducted using a canine model. Longitudinal arteriotomies and venotomies were treated on femoral vein and artery. Laser energy was delivered to the vessel wall via a 400 micrometer optical fiber. The surface temperature at the center of the laser spot was monitored in real time using a hollow glass optical fiber-based two-color infrared thermometer. The surface temperature was limited by either a room-temperature saline drip or direct feedback control of the laser using a mechanical shutter to alternately pass and block the laser. Acute patency was evaluated either visually (leak/no leak) or by in vivo burst pressure measurements. Biochemical assays were performed to investigate the possible laser-induced formation or destruction of enzymatically mediated covalent crosslinks between collagen molecules. Viable welds were created both with and without the use of feedback control. Tissues maintained at 50 degrees Celsius using feedback control had an elevated crosslink count compared to controls, while those irradiated without feedback control experienced a decrease. Differences between the volumetric heating associated with open and closed loop protocols may account for the different effects on collagen crosslinks. Covalent mechanisms may play a role in argon laser vascular fusion.

Original language	English (US)
Title of host publication	Proceedings of SPIE - The International Society for Optical Engineering
Pages	252-256
Number of pages	5
Volume	2970
DOIs	https://doi.org/10.1117/12.275050
State	Published - 1997
Externally published	Yes
Event	Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII - San Jose, CA, United States Duration: Feb 8 1997 → Feb 8 1997

Other

Other	Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII
Country	United States
City	San Jose, CA
Period	2/8/97 → 2/8/97

Keywords

Feedback control
Infrared thermometiy
Tissue fusion
Tissue welding

ASJC Scopus subject areas

Applied Mathematics
Computer Science Applications
Electrical and Electronic Engineering
Electronic, Optical and Magnetic Materials
Condensed Matter Physics

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Cite this

Small IV, W., Celliers, P. M., Kopchok, G. E., Reiser, K. M., Heredia, N. J., Maitland, D. J., Eder, D. C., London, R. A., Heilbron, M., Hussain, F., White, R. A., Da Silva, L. B., & Matthews, D. L. (1997). In-vivo argon laser vascular welding using thermal feedback: Open- and closed-loop patency and collagen crosslinking. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 2970, pp. 252-256) https://doi.org/10.1117/12.275050

In-vivo argon laser vascular welding using thermal feedback : Open- and closed-loop patency and collagen crosslinking. / Small IV, Ward; Celliers, Peter M.; Kopchok, George E.; Reiser, Karen M.; Heredia, Nicholas J.; Maitland, Duncan J.; Eder, David C.; London, Richard A.; Heilbron, Mauricio; Hussain, Farabi; White, Rodney A.; Da Silva, Luiz B.; Matthews, Dennis L.

Proceedings of SPIE - The International Society for Optical Engineering. Vol. 2970 1997. p. 252-256.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Small IV, W, Celliers, PM, Kopchok, GE, Reiser, KM, Heredia, NJ, Maitland, DJ, Eder, DC, London, RA, Heilbron, M, Hussain, F, White, RA, Da Silva, LB & Matthews, DL 1997, In-vivo argon laser vascular welding using thermal feedback: Open- and closed-loop patency and collagen crosslinking. in Proceedings of SPIE - The International Society for Optical Engineering. vol. 2970, pp. 252-256, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII, San Jose, CA, United States, 2/8/97. https://doi.org/10.1117/12.275050

Small IV, Ward ; Celliers, Peter M. ; Kopchok, George E. ; Reiser, Karen M. ; Heredia, Nicholas J. ; Maitland, Duncan J. ; Eder, David C. ; London, Richard A. ; Heilbron, Mauricio ; Hussain, Farabi ; White, Rodney A. ; Da Silva, Luiz B. ; Matthews, Dennis L. / In-vivo argon laser vascular welding using thermal feedback : Open- and closed-loop patency and collagen crosslinking. Proceedings of SPIE - The International Society for Optical Engineering. Vol. 2970 1997. pp. 252-256

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abstract = "An in vivo study of vascular welding with a fiber-delivered argon laser was conducted using a canine model. Longitudinal arteriotomies and venotomies were treated on femoral vein and artery. Laser energy was delivered to the vessel wall via a 400 micrometer optical fiber. The surface temperature at the center of the laser spot was monitored in real time using a hollow glass optical fiber-based two-color infrared thermometer. The surface temperature was limited by either a room-temperature saline drip or direct feedback control of the laser using a mechanical shutter to alternately pass and block the laser. Acute patency was evaluated either visually (leak/no leak) or by in vivo burst pressure measurements. Biochemical assays were performed to investigate the possible laser-induced formation or destruction of enzymatically mediated covalent crosslinks between collagen molecules. Viable welds were created both with and without the use of feedback control. Tissues maintained at 50 degrees Celsius using feedback control had an elevated crosslink count compared to controls, while those irradiated without feedback control experienced a decrease. Differences between the volumetric heating associated with open and closed loop protocols may account for the different effects on collagen crosslinks. Covalent mechanisms may play a role in argon laser vascular fusion.",

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