Abstract
An in vivo study of vascular welding with a fiber-delivered argon laser was conducted using a canine model. Longitudinal arteriotomies and venotomies were treated on femoral vein and artery. Laser energy was delivered to the vessel wall via a 400 micrometer optical fiber. The surface temperature at the center of the laser spot was monitored in real time using a hollow glass optical fiber-based two-color infrared thermometer. The surface temperature was limited by either a room-temperature saline drip or direct feedback control of the laser using a mechanical shutter to alternately pass and block the laser. Acute patency was evaluated either visually (leak/no leak) or by in vivo burst pressure measurements. Biochemical assays were performed to investigate the possible laser-induced formation or destruction of enzymatically mediated covalent crosslinks between collagen molecules. Viable welds were created both with and without the use of feedback control. Tissues maintained at 50 degrees Celsius using feedback control had an elevated crosslink count compared to controls, while those irradiated without feedback control experienced a decrease. Differences between the volumetric heating associated with open and closed loop protocols may account for the different effects on collagen crosslinks. Covalent mechanisms may play a role in argon laser vascular fusion.
| Original language | English (US) |
|---|---|
| Title of host publication | Proceedings of SPIE - The International Society for Optical Engineering |
| Pages | 252-256 |
| Number of pages | 5 |
| Volume | 2970 |
| DOIs | |
| State | Published - 1997 |
| Externally published | Yes |
| Event | Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII - San Jose, CA, United States Duration: Feb 8 1997 → Feb 8 1997 |
Other
| Other | Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII |
|---|---|
| Country | United States |
| City | San Jose, CA |
| Period | 2/8/97 → 2/8/97 |
Fingerprint
Keywords
- Feedback control
- Infrared thermometiy
- Tissue fusion
- Tissue welding
ASJC Scopus subject areas
- Applied Mathematics
- Computer Science Applications
- Electrical and Electronic Engineering
- Electronic, Optical and Magnetic Materials
- Condensed Matter Physics
Cite this
In-vivo argon laser vascular welding using thermal feedback : Open- and closed-loop patency and collagen crosslinking. / Small IV, Ward; Celliers, Peter M.; Kopchok, George E.; Reiser, Karen M.; Heredia, Nicholas J.; Maitland, Duncan J.; Eder, David C.; London, Richard A.; Heilbron, Mauricio; Hussain, Farabi; White, Rodney A.; Da Silva, Luiz B.; Matthews, Dennis L.
Proceedings of SPIE - The International Society for Optical Engineering. Vol. 2970 1997. p. 252-256.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - In-vivo argon laser vascular welding using thermal feedback
T2 - Open- and closed-loop patency and collagen crosslinking
AU - Small IV, Ward
AU - Celliers, Peter M.
AU - Kopchok, George E.
AU - Reiser, Karen M.
AU - Heredia, Nicholas J.
AU - Maitland, Duncan J.
AU - Eder, David C.
AU - London, Richard A.
AU - Heilbron, Mauricio
AU - Hussain, Farabi
AU - White, Rodney A.
AU - Da Silva, Luiz B.
AU - Matthews, Dennis L
PY - 1997
Y1 - 1997
N2 - An in vivo study of vascular welding with a fiber-delivered argon laser was conducted using a canine model. Longitudinal arteriotomies and venotomies were treated on femoral vein and artery. Laser energy was delivered to the vessel wall via a 400 micrometer optical fiber. The surface temperature at the center of the laser spot was monitored in real time using a hollow glass optical fiber-based two-color infrared thermometer. The surface temperature was limited by either a room-temperature saline drip or direct feedback control of the laser using a mechanical shutter to alternately pass and block the laser. Acute patency was evaluated either visually (leak/no leak) or by in vivo burst pressure measurements. Biochemical assays were performed to investigate the possible laser-induced formation or destruction of enzymatically mediated covalent crosslinks between collagen molecules. Viable welds were created both with and without the use of feedback control. Tissues maintained at 50 degrees Celsius using feedback control had an elevated crosslink count compared to controls, while those irradiated without feedback control experienced a decrease. Differences between the volumetric heating associated with open and closed loop protocols may account for the different effects on collagen crosslinks. Covalent mechanisms may play a role in argon laser vascular fusion.
AB - An in vivo study of vascular welding with a fiber-delivered argon laser was conducted using a canine model. Longitudinal arteriotomies and venotomies were treated on femoral vein and artery. Laser energy was delivered to the vessel wall via a 400 micrometer optical fiber. The surface temperature at the center of the laser spot was monitored in real time using a hollow glass optical fiber-based two-color infrared thermometer. The surface temperature was limited by either a room-temperature saline drip or direct feedback control of the laser using a mechanical shutter to alternately pass and block the laser. Acute patency was evaluated either visually (leak/no leak) or by in vivo burst pressure measurements. Biochemical assays were performed to investigate the possible laser-induced formation or destruction of enzymatically mediated covalent crosslinks between collagen molecules. Viable welds were created both with and without the use of feedback control. Tissues maintained at 50 degrees Celsius using feedback control had an elevated crosslink count compared to controls, while those irradiated without feedback control experienced a decrease. Differences between the volumetric heating associated with open and closed loop protocols may account for the different effects on collagen crosslinks. Covalent mechanisms may play a role in argon laser vascular fusion.
KW - Feedback control
KW - Infrared thermometiy
KW - Tissue fusion
KW - Tissue welding
UR - http://www.scopus.com/inward/record.url?scp=0005465665&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0005465665&partnerID=8YFLogxK
U2 - 10.1117/12.275050
DO - 10.1117/12.275050
M3 - Conference contribution
VL - 2970
SP - 252
EP - 256
BT - Proceedings of SPIE - The International Society for Optical Engineering
ER -