TY - JOUR
T1 - In vitro modeling of acute salpingitis caused by Neisseria gonorrhoeae
AU - Draper, Deborah L.
AU - Donegan, Elizabeth A.
AU - James, John F.
AU - Sweet, Richard L
AU - Brooks, George F.
PY - 1980/12/1
Y1 - 1980/12/1
N2 - Normal human fallopian tube organ culture was used as an in vitro model to study Neisseria gonorrhoeae infections. The effects of various gonococcal colony phenotypes on morphology of the epithelium were studied by scanning electron microscopy. After 30 minutes' incubation, there was striking attachment of piliated transparent phenotypes to the epithelium; however, there was no obvious pathology. After 24 hours' incubation, there were microcolony formation, slight swelling and hyperplasia of the mucosa, and occasional focal necrosis and sloughing of ciliated cells. Tissue from acute salpingitis showed widespread destruction of mucosa, hyperplasia, and crypt formation. Duplication of these findings in vitro may require longer incubation and the addition of other host factors.
AB - Normal human fallopian tube organ culture was used as an in vitro model to study Neisseria gonorrhoeae infections. The effects of various gonococcal colony phenotypes on morphology of the epithelium were studied by scanning electron microscopy. After 30 minutes' incubation, there was striking attachment of piliated transparent phenotypes to the epithelium; however, there was no obvious pathology. After 24 hours' incubation, there were microcolony formation, slight swelling and hyperplasia of the mucosa, and occasional focal necrosis and sloughing of ciliated cells. Tissue from acute salpingitis showed widespread destruction of mucosa, hyperplasia, and crypt formation. Duplication of these findings in vitro may require longer incubation and the addition of other host factors.
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M3 - Article
C2 - 7468687
AN - SCOPUS:0019158024
VL - 138
SP - 996
EP - 1002
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 7 PART 2
ER -