In vitro modeling of acute salpingitis caused by Neisseria gonorrhoeae

Deborah L. Draper, Elizabeth A. Donegan, John F. James, Richard L Sweet, George F. Brooks

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Normal human fallopian tube organ culture was used as an in vitro model to study Neisseria gonorrhoeae infections. The effects of various gonococcal colony phenotypes on morphology of the epithelium were studied by scanning electron microscopy. After 30 minutes' incubation, there was striking attachment of piliated transparent phenotypes to the epithelium; however, there was no obvious pathology. After 24 hours' incubation, there were microcolony formation, slight swelling and hyperplasia of the mucosa, and occasional focal necrosis and sloughing of ciliated cells. Tissue from acute salpingitis showed widespread destruction of mucosa, hyperplasia, and crypt formation. Duplication of these findings in vitro may require longer incubation and the addition of other host factors.

Original languageEnglish (US)
Pages (from-to)996-1002
Number of pages7
JournalAmerican Journal of Obstetrics and Gynecology
Issue number7 PART 2
StatePublished - Dec 1 1980

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology


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