In Vitro, In Vivo and Ex Vivo Models for Peripheral Nerve Injury and Regeneration

Andrew Li, Clifford Pereira, Elise Eleanor Hill, Olivia Vukcevic, Aijun Wang

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Peripheral Nerve Injuries (PNI) frequently occur secondary to traumatic injuries. Recovery from these injuries can be expectedly poor, especially in proximal injuries. In order to study and improve peripheral nerve regeneration, scientists rely on peripheral nerve models to identify and test therapeutic interventions. In this review, we discuss the best described and most commonly used peripheral nerve models that scientists have and continue to use to study peripheral nerve physiology and function.

Original languageEnglish (US)
Pages (from-to)344-361
Number of pages18
JournalCurrent Neuropharmacology
Issue number2
StatePublished - Feb 2022


  • Ex vivo models
  • In vitro models
  • In vivo models
  • Organotypic models
  • Peripheral nerve
  • Peripheral nerve injury
  • Peripheral nerve regeneration

ASJC Scopus subject areas

  • Pharmacology
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)


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