In Vitro, In Vivo and Ex Vivo Models for Peripheral Nerve Injury and Regeneration

Andrew Li; Clifford Pereira; Elise Eleanor Hill; Olivia Vukcevic; Aijun Wang

doi:10.2174/1570159X19666210407155543

In Vitro, In Vivo and Ex Vivo Models for Peripheral Nerve Injury and Regeneration

Andrew Li, Clifford Pereira, Elise Eleanor Hill, Olivia Vukcevic, Aijun Wang

Surgery

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Peripheral Nerve Injuries (PNI) frequently occur secondary to traumatic injuries. Recovery from these injuries can be expectedly poor, especially in proximal injuries. In order to study and improve peripheral nerve regeneration, scientists rely on peripheral nerve models to identify and test therapeutic interventions. In this review, we discuss the best described and most commonly used peripheral nerve models that scientists have and continue to use to study peripheral nerve physiology and function.

Original language	English (US)
Pages (from-to)	344-361
Number of pages	18
Journal	Current Neuropharmacology
Volume	20
Issue number	2
DOIs	https://doi.org/10.2174/1570159X19666210407155543
State	Published - Feb 2022

Keywords

Ex vivo models
In vitro models
In vivo models
Organotypic models
Peripheral nerve
Peripheral nerve injury
Peripheral nerve regeneration

ASJC Scopus subject areas

Pharmacology
Neurology
Clinical Neurology
Psychiatry and Mental health
Pharmacology (medical)

Access to Document

10.2174/1570159X19666210407155543

Cite this

@article{3d01f5eca6e645e0852970c8827015c8,

title = "In Vitro, In Vivo and Ex Vivo Models for Peripheral Nerve Injury and Regeneration",

abstract = "Peripheral Nerve Injuries (PNI) frequently occur secondary to traumatic injuries. Recovery from these injuries can be expectedly poor, especially in proximal injuries. In order to study and improve peripheral nerve regeneration, scientists rely on peripheral nerve models to identify and test therapeutic interventions. In this review, we discuss the best described and most commonly used peripheral nerve models that scientists have and continue to use to study peripheral nerve physiology and function.",

keywords = "Ex vivo models, In vitro models, In vivo models, Organotypic models, Peripheral nerve, Peripheral nerve injury, Peripheral nerve regeneration",

author = "Andrew Li and Clifford Pereira and Hill, {Elise Eleanor} and Olivia Vukcevic and Aijun Wang",

note = "Funding Information: This work was in part supported by the American Foundation for Surgery of the Hand Basic Science Grant (20-2608/ A21-1280), UC Davis Academic Federation Innovative Development Award, NIH grant (5R01NS100761), the Shriners Hospitals for Children Research Grants (87200-NCA-19 and 85108-NCA-19). Publisher Copyright: {\textcopyright} 2022 Bentham Science Publishers.",

year = "2022",

month = feb,

doi = "10.2174/1570159X19666210407155543",

language = "English (US)",

volume = "20",

pages = "344--361",

journal = "Current Neuropharmacology",

issn = "1570-159X",

publisher = "Bentham Science Publishers B.V.",

number = "2",

}

TY - JOUR

T1 - In Vitro, In Vivo and Ex Vivo Models for Peripheral Nerve Injury and Regeneration

AU - Li, Andrew

AU - Pereira, Clifford

AU - Hill, Elise Eleanor

AU - Vukcevic, Olivia

AU - Wang, Aijun

N1 - Funding Information: This work was in part supported by the American Foundation for Surgery of the Hand Basic Science Grant (20-2608/ A21-1280), UC Davis Academic Federation Innovative Development Award, NIH grant (5R01NS100761), the Shriners Hospitals for Children Research Grants (87200-NCA-19 and 85108-NCA-19). Publisher Copyright: © 2022 Bentham Science Publishers.

PY - 2022/2

Y1 - 2022/2

N2 - Peripheral Nerve Injuries (PNI) frequently occur secondary to traumatic injuries. Recovery from these injuries can be expectedly poor, especially in proximal injuries. In order to study and improve peripheral nerve regeneration, scientists rely on peripheral nerve models to identify and test therapeutic interventions. In this review, we discuss the best described and most commonly used peripheral nerve models that scientists have and continue to use to study peripheral nerve physiology and function.

AB - Peripheral Nerve Injuries (PNI) frequently occur secondary to traumatic injuries. Recovery from these injuries can be expectedly poor, especially in proximal injuries. In order to study and improve peripheral nerve regeneration, scientists rely on peripheral nerve models to identify and test therapeutic interventions. In this review, we discuss the best described and most commonly used peripheral nerve models that scientists have and continue to use to study peripheral nerve physiology and function.

KW - Ex vivo models

KW - In vitro models

KW - In vivo models

KW - Organotypic models

KW - Peripheral nerve

KW - Peripheral nerve injury

KW - Peripheral nerve regeneration

UR - http://www.scopus.com/inward/record.url?scp=85124905966&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85124905966&partnerID=8YFLogxK

U2 - 10.2174/1570159X19666210407155543

DO - 10.2174/1570159X19666210407155543

M3 - Review article

C2 - 33827409

AN - SCOPUS:85124905966

VL - 20

SP - 344

EP - 361

JO - Current Neuropharmacology

JF - Current Neuropharmacology

SN - 1570-159X

IS - 2

ER -

In Vitro, In Vivo and Ex Vivo Models for Peripheral Nerve Injury and Regeneration

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this