In vitro differentiation potential of mesenchymal stem cells

Jeffrey M. Gimble, Farshid Guilak, Mark E. Nuttall, Solomon Sathishkumar, Martin Vidal, Bruce A. Bunnell

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Mesenchymal stem cells (MSCs) represent a class of multipotent progenitor cells that have been isolated from multiple tissue sites. Of these, adipose tissue and bone marrow offer advantages in terms of access, abundance, and the extent of their documentation in the literature. This review focuses on the in vitro differentiation capability of cells derived from adult human tissue. Multiple, independent studies have demonstrated that MSCs can commit to mesodermal (adipocyte, chondrocyte, hematopoietic support, myocyte, osteoblast, tenocyte), ectodermal (epithelial, glial, neural), and endodermal (hepatocyte, islet cell) lineages. The limitations and promises of these studies in the context of tissue engineering are discussed.

Original languageEnglish (US)
Pages (from-to)228-238
Number of pages11
JournalTransfusion Medicine and Hemotherapy
Volume35
Issue number3
DOIs
StatePublished - Jun 2008
Externally publishedYes

Fingerprint

Mesenchymal Stromal Cells
Cell Lineage
Tissue Engineering
Chondrocytes
Osteoblasts
Islets of Langerhans
Adipocytes
Neuroglia
Documentation
Muscle Cells
Adipose Tissue
Cell Differentiation
Hepatocytes
Stem Cells
Bone Marrow
In Vitro Techniques

Keywords

  • Adipose-derived stem cells
  • Differentiation
  • Mesenchymal stem cells

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Immunology and Allergy
  • Hematology

Cite this

Gimble, J. M., Guilak, F., Nuttall, M. E., Sathishkumar, S., Vidal, M., & Bunnell, B. A. (2008). In vitro differentiation potential of mesenchymal stem cells. Transfusion Medicine and Hemotherapy, 35(3), 228-238. https://doi.org/10.1159/000124281

In vitro differentiation potential of mesenchymal stem cells. / Gimble, Jeffrey M.; Guilak, Farshid; Nuttall, Mark E.; Sathishkumar, Solomon; Vidal, Martin; Bunnell, Bruce A.

In: Transfusion Medicine and Hemotherapy, Vol. 35, No. 3, 06.2008, p. 228-238.

Research output: Contribution to journalArticle

Gimble, JM, Guilak, F, Nuttall, ME, Sathishkumar, S, Vidal, M & Bunnell, BA 2008, 'In vitro differentiation potential of mesenchymal stem cells', Transfusion Medicine and Hemotherapy, vol. 35, no. 3, pp. 228-238. https://doi.org/10.1159/000124281
Gimble JM, Guilak F, Nuttall ME, Sathishkumar S, Vidal M, Bunnell BA. In vitro differentiation potential of mesenchymal stem cells. Transfusion Medicine and Hemotherapy. 2008 Jun;35(3):228-238. https://doi.org/10.1159/000124281
Gimble, Jeffrey M. ; Guilak, Farshid ; Nuttall, Mark E. ; Sathishkumar, Solomon ; Vidal, Martin ; Bunnell, Bruce A. / In vitro differentiation potential of mesenchymal stem cells. In: Transfusion Medicine and Hemotherapy. 2008 ; Vol. 35, No. 3. pp. 228-238.
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