In vitro delineation of human brain-stem anatomy using a small resonator: Correlation with macroscopic and histological findings

J. Mäurer, T. Mitrovic, Friedrich D Knollmann, E. Lüdtke, H. Requardt

Research output: Contribution to journalArticle

Abstract

Our purpose was to investigate the potential of an experimental animal coil using a commercial MRI unit to delineate the anatomical structure of the human brain stem. Three formaldehyde-fixed brain-stem specimens were examined by MRI and sectioned perpendicular to their longitudinal axis. The images were compared with gross anatomy and myelin-stained histological sections. Fibre tracts and nuclei which were not evident on examination of the unstained specimen were readily identified by MRI. Due to its inherent grey/white matter contrast, MRI with a high-resolution coil delineates anatomical structures in a way comparable to the myelin-stained histological sections. However, pigmented structures, readily visible on examination of the unstained specimen were discernible on neither MRI nor on myelin-stained sections. The excellent anatomical detail and grey/white matter contrast provided by these images could make MRI a useful adjunct to the pathologist investigating brain disease.

Original languageEnglish (US)
Pages (from-to)217-220
Number of pages4
JournalNeuroradiology
Volume38
Issue number3
DOIs
StatePublished - Apr 1996
Externally publishedYes

Keywords

  • Brain stem
  • Magnetic resonance imaging, experimental

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Radiological and Ultrasound Technology

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