Abstract
Our purpose was to investigate the potential of an experimental animal coil using a commercial MRI unit to delineate the anatomical structure of the human brain stem. Three formaldehyde-fixed brain-stem specimens were examined by MRI and sectioned perpendicular to their longitudinal axis. The images were compared with gross anatomy and myelin-stained histological sections. Fibre tracts and nuclei which were not evident on examination of the unstained specimen were readily identified by MRI. Due to its inherent grey/white matter contrast, MRI with a high-resolution coil delineates anatomical structures in a way comparable to the myelin-stained histological sections. However, pigmented structures, readily visible on examination of the unstained specimen were discernible on neither MRI nor on myelin-stained sections. The excellent anatomical detail and grey/white matter contrast provided by these images could make MRI a useful adjunct to the pathologist investigating brain disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 217-220 |
| Number of pages | 4 |
| Journal | Neuroradiology |
| Volume | 38 |
| Issue number | 3 |
| DOIs | |
| State | Published - Apr 1996 |
| Externally published | Yes |
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Keywords
- Brain stem
- Magnetic resonance imaging, experimental
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Clinical Neurology
- Radiological and Ultrasound Technology
Cite this
In vitro delineation of human brain-stem anatomy using a small resonator : Correlation with macroscopic and histological findings. / Mäurer, J.; Mitrovic, T.; Knollmann, Friedrich D; Lüdtke, E.; Requardt, H.
In: Neuroradiology, Vol. 38, No. 3, 04.1996, p. 217-220.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In vitro delineation of human brain-stem anatomy using a small resonator
T2 - Correlation with macroscopic and histological findings
AU - Mäurer, J.
AU - Mitrovic, T.
AU - Knollmann, Friedrich D
AU - Lüdtke, E.
AU - Requardt, H.
PY - 1996/4
Y1 - 1996/4
N2 - Our purpose was to investigate the potential of an experimental animal coil using a commercial MRI unit to delineate the anatomical structure of the human brain stem. Three formaldehyde-fixed brain-stem specimens were examined by MRI and sectioned perpendicular to their longitudinal axis. The images were compared with gross anatomy and myelin-stained histological sections. Fibre tracts and nuclei which were not evident on examination of the unstained specimen were readily identified by MRI. Due to its inherent grey/white matter contrast, MRI with a high-resolution coil delineates anatomical structures in a way comparable to the myelin-stained histological sections. However, pigmented structures, readily visible on examination of the unstained specimen were discernible on neither MRI nor on myelin-stained sections. The excellent anatomical detail and grey/white matter contrast provided by these images could make MRI a useful adjunct to the pathologist investigating brain disease.
AB - Our purpose was to investigate the potential of an experimental animal coil using a commercial MRI unit to delineate the anatomical structure of the human brain stem. Three formaldehyde-fixed brain-stem specimens were examined by MRI and sectioned perpendicular to their longitudinal axis. The images were compared with gross anatomy and myelin-stained histological sections. Fibre tracts and nuclei which were not evident on examination of the unstained specimen were readily identified by MRI. Due to its inherent grey/white matter contrast, MRI with a high-resolution coil delineates anatomical structures in a way comparable to the myelin-stained histological sections. However, pigmented structures, readily visible on examination of the unstained specimen were discernible on neither MRI nor on myelin-stained sections. The excellent anatomical detail and grey/white matter contrast provided by these images could make MRI a useful adjunct to the pathologist investigating brain disease.
KW - Brain stem
KW - Magnetic resonance imaging, experimental
UR - http://www.scopus.com/inward/record.url?scp=0029872683&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029872683&partnerID=8YFLogxK
U2 - 10.1007/s002340050233
DO - 10.1007/s002340050233
M3 - Article
C2 - 8741190
AN - SCOPUS:0029872683
VL - 38
SP - 217
EP - 220
JO - Neuroradiology
JF - Neuroradiology
SN - 0028-3940
IS - 3
ER -