Abstract
Organ and cell cultures of BALB/cfC3H mammary tumor tissue release infectious MTV into the medium. Not only were bioassays of culture fluid for MTV positive, but also radioisotope‐labelled MTV‐RNA and MTV B‐particle antigenicity could be detected in the culture fluid. In addition, type B virus particles were found budding from the cell membranes. Bioassays of control MTV‐free BALB/c tumor cultures were negative, as were radio‐chemical, immunological and morphological studies. Thus, infectivity could be correlated to the presence of labelled B particles in the cultures.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 211-216 |
| Number of pages | 6 |
| Journal | International Journal of Cancer |
| Volume | 5 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 1 1970 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
In vitro cultivation of the mouse mammary tumor virus : Correlation of infectivity and morphology with radioisotope studies. / Cardiff, Robert; Blair, Phyllis B.
In: International Journal of Cancer, Vol. 5, No. 2, 01.01.1970, p. 211-216.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In vitro cultivation of the mouse mammary tumor virus
T2 - Correlation of infectivity and morphology with radioisotope studies
AU - Cardiff, Robert
AU - Blair, Phyllis B.
PY - 1970/1/1
Y1 - 1970/1/1
N2 - Organ and cell cultures of BALB/cfC3H mammary tumor tissue release infectious MTV into the medium. Not only were bioassays of culture fluid for MTV positive, but also radioisotope‐labelled MTV‐RNA and MTV B‐particle antigenicity could be detected in the culture fluid. In addition, type B virus particles were found budding from the cell membranes. Bioassays of control MTV‐free BALB/c tumor cultures were negative, as were radio‐chemical, immunological and morphological studies. Thus, infectivity could be correlated to the presence of labelled B particles in the cultures.
AB - Organ and cell cultures of BALB/cfC3H mammary tumor tissue release infectious MTV into the medium. Not only were bioassays of culture fluid for MTV positive, but also radioisotope‐labelled MTV‐RNA and MTV B‐particle antigenicity could be detected in the culture fluid. In addition, type B virus particles were found budding from the cell membranes. Bioassays of control MTV‐free BALB/c tumor cultures were negative, as were radio‐chemical, immunological and morphological studies. Thus, infectivity could be correlated to the presence of labelled B particles in the cultures.
UR - http://www.scopus.com/inward/record.url?scp=0014946916&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0014946916&partnerID=8YFLogxK
U2 - 10.1002/ijc.2910050207
DO - 10.1002/ijc.2910050207
M3 - Article
VL - 5
SP - 211
EP - 216
JO - International Journal of Cancer
JF - International Journal of Cancer
SN - 0020-7136
IS - 2
ER -