In vitro adherence of Lactobacillus species to vaginal epithelial cells

Janice R. Wood, Richard L Sweet, Anthony Catena, W. Keith Hadley, Marilyn Robbie

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Because of the reported useof yogurt douches for the treatment of vaginitis, the adherence of Lactobacillus species to normal human vaginal epithelial cells was tested by in vitro methods. L. acidophilus and L. bulgaricus isolated from three commercial yogurts were compared to L. acidophilus, L. fermentum, L. cellobiosus, and L. casei isolated from clinical specimens and from American Type Culture Collection cultures. L. acidophilus isolated from Lactinex tablets was also tested. No significant difference was found among the 19 clinical isolates, the American Type Culture Collection cultures, and the Lactinex isolate, but all showed significantly higher (p < 0.01) adherence than any Lactobacillus isolated from yogurt. The presence of Gardnerella vaginalis, which adheres strongly to vaginal epithelial cells, was found to interfere with the adherence of lactobacilli from all sources studied.

Original languageEnglish (US)
Pages (from-to)740-743
Number of pages4
JournalAmerican Journal of Obstetrics and Gynecology
Issue number7
StatePublished - Dec 1 1985


  • Adherence
  • Lactobacillus
  • vaginitis

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology


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