In vitro activity of readily available household materials against HIV-1: Is bleach enough?

N. Flynn, S. Jain, E. M. Keddie, J. R. Carlson, M. B. Jennings, H. W. Haverkos, N. Nassar, R. Anderson, Stuart H Cohen, D. Goldberg

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

This report describes experiments assessing the effectiveness against HIV of potential disinfecting agents that are commonly available to IDU when they are sharing syringes. We exposed cell-free HIV, HIV-infected cells, and HIV- infected blood containing known quantities of HIV to household cleaning agents, alcohols, peroxide, and highly acidic materials for 1 min, in order to examine the effects of these materials on the infectivity of the HIV. Undiluted liquid laundry bleach and dilute liquid dish detergent reduced the number of culturable HIV to an undetectable level under the experimental conditions used. Diluted bleach was not completely effective. Other potential disinfecting agents, including ethanol, isopropyl alcohol, and hydrogen peroxide, were unable to disinfect high numbers of HIV-infected cells or infected blood. Liquid dish detergent warrants further study as a possible acceptable alternative to bleach. Our data provide support for recommendations to IDU that they disinfect shared syringes every time between users with full-strength liquid laundry bleach to reduce their risk of acquiring or transmitting HIV. When bleach is not available, liquid dish detergent or other available disinfecting agents such as rubbing alcohol, hydrogen peroxide, or high alcohol content beverages are more effective than water at disinfecting HIV, recognizing that these materials are less effective than bleach. Although these materials are effective, they should not be viewed as a substitute for decreased sharing of injection equipment by IDU, or increased availability of sterile needles and syringes.

Original languageEnglish (US)
Pages (from-to)747-753
Number of pages7
JournalJournal of Acquired Immune Deficiency Syndromes
Volume7
Issue number7
StatePublished - 1994

Fingerprint

HIV-1
HIV
Detergents
2-Propanol
Syringes
Hydrogen Peroxide
Alcohols
In Vitro Techniques
Needle Sharing
Beverages
Peroxides
Needles
Ethanol
Equipment and Supplies
Injections
Water

Keywords

  • Bleach
  • Disinfection
  • HIV prevention
  • Injection drug use
  • Needles and syringes

ASJC Scopus subject areas

  • Virology
  • Immunology and Allergy

Cite this

Flynn, N., Jain, S., Keddie, E. M., Carlson, J. R., Jennings, M. B., Haverkos, H. W., ... Goldberg, D. (1994). In vitro activity of readily available household materials against HIV-1: Is bleach enough? Journal of Acquired Immune Deficiency Syndromes, 7(7), 747-753.

In vitro activity of readily available household materials against HIV-1 : Is bleach enough? / Flynn, N.; Jain, S.; Keddie, E. M.; Carlson, J. R.; Jennings, M. B.; Haverkos, H. W.; Nassar, N.; Anderson, R.; Cohen, Stuart H; Goldberg, D.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 7, No. 7, 1994, p. 747-753.

Research output: Contribution to journalArticle

Flynn, N, Jain, S, Keddie, EM, Carlson, JR, Jennings, MB, Haverkos, HW, Nassar, N, Anderson, R, Cohen, SH & Goldberg, D 1994, 'In vitro activity of readily available household materials against HIV-1: Is bleach enough?', Journal of Acquired Immune Deficiency Syndromes, vol. 7, no. 7, pp. 747-753.
Flynn N, Jain S, Keddie EM, Carlson JR, Jennings MB, Haverkos HW et al. In vitro activity of readily available household materials against HIV-1: Is bleach enough? Journal of Acquired Immune Deficiency Syndromes. 1994;7(7):747-753.
Flynn, N. ; Jain, S. ; Keddie, E. M. ; Carlson, J. R. ; Jennings, M. B. ; Haverkos, H. W. ; Nassar, N. ; Anderson, R. ; Cohen, Stuart H ; Goldberg, D. / In vitro activity of readily available household materials against HIV-1 : Is bleach enough?. In: Journal of Acquired Immune Deficiency Syndromes. 1994 ; Vol. 7, No. 7. pp. 747-753.
@article{31dc3cc822d84e979abaab154b7dd40e,
title = "In vitro activity of readily available household materials against HIV-1: Is bleach enough?",
abstract = "This report describes experiments assessing the effectiveness against HIV of potential disinfecting agents that are commonly available to IDU when they are sharing syringes. We exposed cell-free HIV, HIV-infected cells, and HIV- infected blood containing known quantities of HIV to household cleaning agents, alcohols, peroxide, and highly acidic materials for 1 min, in order to examine the effects of these materials on the infectivity of the HIV. Undiluted liquid laundry bleach and dilute liquid dish detergent reduced the number of culturable HIV to an undetectable level under the experimental conditions used. Diluted bleach was not completely effective. Other potential disinfecting agents, including ethanol, isopropyl alcohol, and hydrogen peroxide, were unable to disinfect high numbers of HIV-infected cells or infected blood. Liquid dish detergent warrants further study as a possible acceptable alternative to bleach. Our data provide support for recommendations to IDU that they disinfect shared syringes every time between users with full-strength liquid laundry bleach to reduce their risk of acquiring or transmitting HIV. When bleach is not available, liquid dish detergent or other available disinfecting agents such as rubbing alcohol, hydrogen peroxide, or high alcohol content beverages are more effective than water at disinfecting HIV, recognizing that these materials are less effective than bleach. Although these materials are effective, they should not be viewed as a substitute for decreased sharing of injection equipment by IDU, or increased availability of sterile needles and syringes.",
keywords = "Bleach, Disinfection, HIV prevention, Injection drug use, Needles and syringes",
author = "N. Flynn and S. Jain and Keddie, {E. M.} and Carlson, {J. R.} and Jennings, {M. B.} and Haverkos, {H. W.} and N. Nassar and R. Anderson and Cohen, {Stuart H} and D. Goldberg",
year = "1994",
language = "English (US)",
volume = "7",
pages = "747--753",
journal = "Journal of acquired immune deficiency syndromes (1999)",
issn = "1525-4135",
publisher = "Lippincott Williams and Wilkins",
number = "7",

}

TY - JOUR

T1 - In vitro activity of readily available household materials against HIV-1

T2 - Is bleach enough?

AU - Flynn, N.

AU - Jain, S.

AU - Keddie, E. M.

AU - Carlson, J. R.

AU - Jennings, M. B.

AU - Haverkos, H. W.

AU - Nassar, N.

AU - Anderson, R.

AU - Cohen, Stuart H

AU - Goldberg, D.

PY - 1994

Y1 - 1994

N2 - This report describes experiments assessing the effectiveness against HIV of potential disinfecting agents that are commonly available to IDU when they are sharing syringes. We exposed cell-free HIV, HIV-infected cells, and HIV- infected blood containing known quantities of HIV to household cleaning agents, alcohols, peroxide, and highly acidic materials for 1 min, in order to examine the effects of these materials on the infectivity of the HIV. Undiluted liquid laundry bleach and dilute liquid dish detergent reduced the number of culturable HIV to an undetectable level under the experimental conditions used. Diluted bleach was not completely effective. Other potential disinfecting agents, including ethanol, isopropyl alcohol, and hydrogen peroxide, were unable to disinfect high numbers of HIV-infected cells or infected blood. Liquid dish detergent warrants further study as a possible acceptable alternative to bleach. Our data provide support for recommendations to IDU that they disinfect shared syringes every time between users with full-strength liquid laundry bleach to reduce their risk of acquiring or transmitting HIV. When bleach is not available, liquid dish detergent or other available disinfecting agents such as rubbing alcohol, hydrogen peroxide, or high alcohol content beverages are more effective than water at disinfecting HIV, recognizing that these materials are less effective than bleach. Although these materials are effective, they should not be viewed as a substitute for decreased sharing of injection equipment by IDU, or increased availability of sterile needles and syringes.

AB - This report describes experiments assessing the effectiveness against HIV of potential disinfecting agents that are commonly available to IDU when they are sharing syringes. We exposed cell-free HIV, HIV-infected cells, and HIV- infected blood containing known quantities of HIV to household cleaning agents, alcohols, peroxide, and highly acidic materials for 1 min, in order to examine the effects of these materials on the infectivity of the HIV. Undiluted liquid laundry bleach and dilute liquid dish detergent reduced the number of culturable HIV to an undetectable level under the experimental conditions used. Diluted bleach was not completely effective. Other potential disinfecting agents, including ethanol, isopropyl alcohol, and hydrogen peroxide, were unable to disinfect high numbers of HIV-infected cells or infected blood. Liquid dish detergent warrants further study as a possible acceptable alternative to bleach. Our data provide support for recommendations to IDU that they disinfect shared syringes every time between users with full-strength liquid laundry bleach to reduce their risk of acquiring or transmitting HIV. When bleach is not available, liquid dish detergent or other available disinfecting agents such as rubbing alcohol, hydrogen peroxide, or high alcohol content beverages are more effective than water at disinfecting HIV, recognizing that these materials are less effective than bleach. Although these materials are effective, they should not be viewed as a substitute for decreased sharing of injection equipment by IDU, or increased availability of sterile needles and syringes.

KW - Bleach

KW - Disinfection

KW - HIV prevention

KW - Injection drug use

KW - Needles and syringes

UR - http://www.scopus.com/inward/record.url?scp=0028308204&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028308204&partnerID=8YFLogxK

M3 - Article

C2 - 8207658

AN - SCOPUS:0028308204

VL - 7

SP - 747

EP - 753

JO - Journal of acquired immune deficiency syndromes (1999)

JF - Journal of acquired immune deficiency syndromes (1999)

SN - 1525-4135

IS - 7

ER -