In utero exposure to poly− and perfluoroalkyl substances (PFASs) and subsequent breast cancer

Barbara A. Cohn, Michele La Merrill, Nickilou Y. Krigbaum, Miaomiao Wang, June Soo Park, Myrto Petreas, Gregory Yeh, Russell C. Hovey, Lauren Zimmermann, Piera M. Cirillo

Research output: Contribution to journalArticle

Abstract

We tested the hypothesis that maternal perinatal serum levels of poly and perfluoroalkyl substances (PFASs) predict risk for breast cancer in daughters in a 54-year follow-up of 9300 daughters born 1959–1967 in the Child Health and Development Studies pregnancy cohort. Total cholesterol and PFASs were measured in archived maternal perinatal serum for 102 daughter breast cancer cases diagnosed by age 52, and 310 controls matched on birth year and blood draw trimester. High maternal N-ethyl-perfluorooctane sulfonamido acetic acid (EtFOSAA), a precursor of perfluorooctane sulfonic acid (PFOS), in combination with high maternal total cholesterol predicted a 3.6-fold increased risk of breast cancer (pinteraction<0.05). Conversely, maternal PFOS was associated with decreased daughters’ breast cancer risk. Predictions were robust to alternative modeling and independent of other maternal factors. Future generations continue to be exposed to ubiquitous, persistent PFASs. These findings are relevant to breast cancer prevention if confirmed experimentally and where possible, in additional epidemiology studies of internal doses of PFASs and other chemical mixtures especially during vulnerable windows in early life.

Original languageEnglish (US)
JournalReproductive Toxicology
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Mothers
Breast Neoplasms
Cholesterol
Epidemiology
Nuclear Family
Acetic Acid
Blood
Health
Social Responsibility
Child Development
Serum
Cohort Studies
Parturition
Pregnancy
perfluorooctane sulfonic acid
perfluorooctane

Keywords

  • Breast cancer
  • CHDS
  • Child Health and Development StudiesI
  • Cholesterol
  • EtFOSAA
  • In utero window of susceptibility
  • PFASs
  • PFOS

ASJC Scopus subject areas

  • Toxicology

Cite this

In utero exposure to poly− and perfluoroalkyl substances (PFASs) and subsequent breast cancer. / Cohn, Barbara A.; La Merrill, Michele; Krigbaum, Nickilou Y.; Wang, Miaomiao; Park, June Soo; Petreas, Myrto; Yeh, Gregory; Hovey, Russell C.; Zimmermann, Lauren; Cirillo, Piera M.

In: Reproductive Toxicology, 01.01.2019.

Research output: Contribution to journalArticle

Cohn, Barbara A. ; La Merrill, Michele ; Krigbaum, Nickilou Y. ; Wang, Miaomiao ; Park, June Soo ; Petreas, Myrto ; Yeh, Gregory ; Hovey, Russell C. ; Zimmermann, Lauren ; Cirillo, Piera M. / In utero exposure to poly− and perfluoroalkyl substances (PFASs) and subsequent breast cancer. In: Reproductive Toxicology. 2019.
@article{615c258766f54af08e6431bbf4b12d9c,
title = "In utero exposure to poly− and perfluoroalkyl substances (PFASs) and subsequent breast cancer",
abstract = "We tested the hypothesis that maternal perinatal serum levels of poly and perfluoroalkyl substances (PFASs) predict risk for breast cancer in daughters in a 54-year follow-up of 9300 daughters born 1959–1967 in the Child Health and Development Studies pregnancy cohort. Total cholesterol and PFASs were measured in archived maternal perinatal serum for 102 daughter breast cancer cases diagnosed by age 52, and 310 controls matched on birth year and blood draw trimester. High maternal N-ethyl-perfluorooctane sulfonamido acetic acid (EtFOSAA), a precursor of perfluorooctane sulfonic acid (PFOS), in combination with high maternal total cholesterol predicted a 3.6-fold increased risk of breast cancer (pinteraction<0.05). Conversely, maternal PFOS was associated with decreased daughters’ breast cancer risk. Predictions were robust to alternative modeling and independent of other maternal factors. Future generations continue to be exposed to ubiquitous, persistent PFASs. These findings are relevant to breast cancer prevention if confirmed experimentally and where possible, in additional epidemiology studies of internal doses of PFASs and other chemical mixtures especially during vulnerable windows in early life.",
keywords = "Breast cancer, CHDS, Child Health and Development StudiesI, Cholesterol, EtFOSAA, In utero window of susceptibility, PFASs, PFOS",
author = "Cohn, {Barbara A.} and {La Merrill}, Michele and Krigbaum, {Nickilou Y.} and Miaomiao Wang and Park, {June Soo} and Myrto Petreas and Gregory Yeh and Hovey, {Russell C.} and Lauren Zimmermann and Cirillo, {Piera M.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.reprotox.2019.06.012",
language = "English (US)",
journal = "Reproductigve Toxicoloy",
issn = "0890-6238",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - In utero exposure to poly− and perfluoroalkyl substances (PFASs) and subsequent breast cancer

AU - Cohn, Barbara A.

AU - La Merrill, Michele

AU - Krigbaum, Nickilou Y.

AU - Wang, Miaomiao

AU - Park, June Soo

AU - Petreas, Myrto

AU - Yeh, Gregory

AU - Hovey, Russell C.

AU - Zimmermann, Lauren

AU - Cirillo, Piera M.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - We tested the hypothesis that maternal perinatal serum levels of poly and perfluoroalkyl substances (PFASs) predict risk for breast cancer in daughters in a 54-year follow-up of 9300 daughters born 1959–1967 in the Child Health and Development Studies pregnancy cohort. Total cholesterol and PFASs were measured in archived maternal perinatal serum for 102 daughter breast cancer cases diagnosed by age 52, and 310 controls matched on birth year and blood draw trimester. High maternal N-ethyl-perfluorooctane sulfonamido acetic acid (EtFOSAA), a precursor of perfluorooctane sulfonic acid (PFOS), in combination with high maternal total cholesterol predicted a 3.6-fold increased risk of breast cancer (pinteraction<0.05). Conversely, maternal PFOS was associated with decreased daughters’ breast cancer risk. Predictions were robust to alternative modeling and independent of other maternal factors. Future generations continue to be exposed to ubiquitous, persistent PFASs. These findings are relevant to breast cancer prevention if confirmed experimentally and where possible, in additional epidemiology studies of internal doses of PFASs and other chemical mixtures especially during vulnerable windows in early life.

AB - We tested the hypothesis that maternal perinatal serum levels of poly and perfluoroalkyl substances (PFASs) predict risk for breast cancer in daughters in a 54-year follow-up of 9300 daughters born 1959–1967 in the Child Health and Development Studies pregnancy cohort. Total cholesterol and PFASs were measured in archived maternal perinatal serum for 102 daughter breast cancer cases diagnosed by age 52, and 310 controls matched on birth year and blood draw trimester. High maternal N-ethyl-perfluorooctane sulfonamido acetic acid (EtFOSAA), a precursor of perfluorooctane sulfonic acid (PFOS), in combination with high maternal total cholesterol predicted a 3.6-fold increased risk of breast cancer (pinteraction<0.05). Conversely, maternal PFOS was associated with decreased daughters’ breast cancer risk. Predictions were robust to alternative modeling and independent of other maternal factors. Future generations continue to be exposed to ubiquitous, persistent PFASs. These findings are relevant to breast cancer prevention if confirmed experimentally and where possible, in additional epidemiology studies of internal doses of PFASs and other chemical mixtures especially during vulnerable windows in early life.

KW - Breast cancer

KW - CHDS

KW - Child Health and Development StudiesI

KW - Cholesterol

KW - EtFOSAA

KW - In utero window of susceptibility

KW - PFASs

KW - PFOS

UR - http://www.scopus.com/inward/record.url?scp=85070703367&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85070703367&partnerID=8YFLogxK

U2 - 10.1016/j.reprotox.2019.06.012

DO - 10.1016/j.reprotox.2019.06.012

M3 - Article

C2 - 31323350

AN - SCOPUS:85070703367

JO - Reproductigve Toxicoloy

JF - Reproductigve Toxicoloy

SN - 0890-6238

ER -